254 1263 Hsa_WNT4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----SPRSCL----------------------------------------------------------------------------------RS-LRLLVFAVFSAAA---------SNW---------------------------LYLAKLSSVG----SIS------------------------EEETC--EK---L--KGLI-----Q-R-QVQMC------KRNLEVM-D-SVRRGAQLAIEECQYQFRNRRWNCSTL------------------------------------DSLPVFG--K--V---VTQ-------------------------G-TREAAFVYAISSAGVAFAVTRACSS-GEL-EKC-G-C-DRTV-----------------------------HG--VSPQ---------------------------------------------G--------F-------QWSGC-SD-NIAYGVAFSQSFVD-VRE-----RSK---------------------------------------------GASSSRALMNLHNNEAG-RK----AIL--THMRVECKCHGVSGS-----CEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRV------------GSSRAL-VPRNAQ-----------------------------------------------------------------------------------FKPHTDE-D-LVY-LEPSP-DFCEQDMRS-GVLG----TRGRTCNK-T------------------------------SK-AIDG-CELLC--CGRGFHTAQVELAE-RCSC-KFH------WCC--FVKCRQ-CQRLVELHTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt4a ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----SSEYLI----------------------------------------------------------------------------------RS-LLMLFLALFSANA---------SNW---------------------------LYLAKLSSVG----SIS------------------------DEETC--EK---L--RGLI-----Q-R-QVQIC------KRNVEVM-D-AVRRGAQLAIDECQYQFRNRRWNCSTL------------------------------------ESVPVFG--K--V---VTQ-------------------------G-TREAAFVYAISAASVAFAVTRACSS-GEL-DKC-G-C-DRNV-----------------------------HG--VSPE---------------------------------------------G--------F-------QWSGC-SD-NIAYGVAFSQSFVD-IRE-----RSK---------------------------------------------GQSSNRALMNLHNNEAG-RK----AIL--NHMRVECKCHGVSGS-----CEVKTCWKAMPPFRKVGNVIKEKFDGATEVELRKV------------GTTKVL-VPRNSQ-----------------------------------------------------------------------------------FKPHTDE-D-LVY-LDPSP-DFCEHDPRTPGIMG----TAGRFCNK-T------------------------------SK-AIDG-CELMC--CGRGFHTEEVEVVD-RCSC-KFH------WCC--YVKCKQ-CRKMVEMHTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----PTLNVI----------------------------------------------------------------------------------LVFLLYALVSTCSATA---------NQW---------------------------LRVA--ASAV----SVR------------------------TEDAC--EK---L--HGLI-----S-R-QVQIC------KRNVEVM-D-SVKEGARMSIEECQFQFRHRRWNCSTL------------------------------I----NRRGPVFG--K--V---LEE-------------------------G-TREAAFVHSISAAGVAHAVTRACSS-GEL-ERC-G-C-NRTV-----------------------------RG--TIPE---------------------------------------------G--------F-------HWAGC-SD-NFAFGAAFSQTFVD-ARE-----RGR--------------------------------------------VAATSSRALMNLHNNEAG-RR----NLV--DHMKTECKCHGVSGS-----CELKTCWRAMPPFREVGARLKEKFDGATEVQQKKI------------GSRREL-VPLNSD-----------------------------------------------------------------------------------FKPHSSS-D-LVY-LDASP-DFCVRDTKV-GSMG----TVGRVCNK-T------------------------------SK-AIDG-CELLC--CGRGYNTHTREVVE-RCSC-KFH------WCC--YVKCKT-CRRTVEVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----PTLNVI----------------------------------------------------------------------------------LVFLLYALVSTCSATA---------NQW---------------------------LRVA--ASAV----SVR------------------------TEDAC--EK---L--HGLI-----S-R-QVQIC------KRNVEVM-D-SVKEGARMSIEECQFQFRHRRWNCSTL------------------------------I----NRRGPVFG--K--V---LEE-------------------------G-TREAAFVHSISAAGVAHAVTRACSS-GEL-ERC-G-C-DRTV-----------------------------RG--TSPE---------------------------------------------G--------F-------QWAGC-SD-NVAFGSAFSQTFVD-ARE-----RGR--------------------------------------------VAATSSRALMNLHNNEAG-RR----NLV--DHMKTECKCHGVSGS-----CELKTCWRAMPPFREVGARLKEKFDGATEVQQKKI------------GSRREL-VPLNSD-----------------------------------------------------------------------------------FKPHSSS-D-LVY-LDASP-DFCVRDTKV-GSMG----TVGRVCNK-T------------------------------SK-AIDG-CELLC--CGRGYNTHTREVVE-RCSC-KFH------WCC--YVKCKT-CRRTVEVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----PTLNVI----------------------------------------------------------------------------------LVFLLYALVSTCSATA---------NQW---------------------------LRVA--ASAV----SVR------------------------TEDAC--EK---L--HGLI-----S-R-QVQIC------KRNVEVM-D-SVKEGARMSIEECQFQFRHRRWNCSTL------------------------------I----NRRGPVFG--K--V---LEE-------------------------G-TREAAFVHSISAAGVAHAVTRACSS-GEL-ERC-G-C-DRTV-----------------------------RG--TSAE---------------------------------------------G--------F-------QWAGC-SD-NVAFGAAFSQTFVD-ARE-----RGR--------------------------------------------AAATSSRALMNLHNNEAG-RR----NLV--DHMKTECKCHGVSGS-----CELKTCWRAMPPFREVGARLKEKFDGATEVQQKKI------------GSRREL-VPLNSD-----------------------------------------------------------------------------------FKPHSSS-D-LVY-LDASP-DFCVRDTKV-GSMG----TVGRVCNK-T------------------------------SK-AIDG-CELLC--CGRGYNTHTREVVE-RCSC-KFH------WCC--YVRCKT-CRRTVEVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------------------------QQS---------------------------RAIFRVSSIGI--NTID------------------------DEDKC--EM---L--PGLI-----N-R-QIQVC------KRNVEVM-N-SVAEGADMAISECQYQFKNRRWNCSTVDS------------------------ISG-T----SLKGPVFG--K--V---LER-------------------------G-TREAAFVHAISSAGVAHSVTTACSS-GEL-EKC-G-C-DASV-----------------------------TG--NSPD---------------------------------------------G--------F-------QWSGC-SD-HIDYGSIFSKEFVD-ARE-----KRG--------------------------------------------RKQPNNRSLMNLHNNEAG-RR----TIE--SNMKIQCKCHGVSGS-----CETKTCWRALPTFREVGEKLKEKFDGATEVRTGRI------------GSRPQL-VPLHPY-----------------------------------------------------------------------------------FKPHTDA-D-LVY-LDESP-DFCENDLKS-GSLG----TTGRRCNK-T------------------------------SK-AIDG-CDLMC--CGRGYDSYTEELVE-RCSC-KFH------WCC--YVKCKK-CRRTVQINICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt4 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALAKMTSLG----SIT------------------------DENHC--DS---L--YGFV-----K-R-QKKLC------RKNLEIM-D-NVKVGARVAIEECQSQFGNRRWNCSTA------------------------------------NSKKLFG--N--VI--LKQ-------------------------G-TREAAFVHAISSAGVAHSVTRACSS-GTL-QKC-G-C-DRTV-----------------------------RG--RSPE---------------------------------------------G--------F-------EWSGC-SD-NIDYGMAFSKAFVD-ARE-----KGK--------------------------------------------KRKNTGRALMNLHNNEAG-RK----AVD--ANMKVECKCHGVSGS-----CEMRTCWKAMPSFKKVGEILKEKFDGATEVKHQVK------------GTRNEL-VPLNPQ-----------------------------------------------------------------------------------FKRHTES-D-LVY-MVASP-DFCEADKKT-GSLG----THGRICNK-T------------------------------SK-AIDG-CELLC--CGRGYRTRIVTIKE-RCFC-KFL------WCC--YVKCKE-CTRQIEEHTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--K--ALDFC----------------------------------------------------------------------------------LI-LLLLEELCGSTSG---------LRW---------------------------LALATVGSVD----HIQ------------------------KEEAC--DT---L--SGLV-----K-R-QKKIC------KRNIEVM-H-AVKKGAVSAIDECQYQFQNRRWNCSTV-----------------------------------DHGSAVFG--N--V---LNA-------------------------G-TREAAFVHAISSAGVTYAVTKACSS-GQV-DKC-G-C-DRSI-----------------------------RG--KSPQ---------------------------------------------G--------F-------EWAGC-SD-NVAYGSAFCGMFVD-ARE-----RAK---------------------------------------------GRQSSRALMNLHNNEAG-RL----AVE--ENMKVQCKCHGVSGS-----CEMKTCWRGLPSFREVGAMLKDRFDGASEVEEQKV------------GSRKKL-VPKNTQ-----------------------------------------------------------------------------------FKPHETQ-D-LVY-LEASP-DYCISDPET-GSLG----TSGRTCNR-S------------------------------SK-AIDG-CELMC--CGRGFNVKRRVVDE-RCHC-KFH------WCC--YVKCQQ-CKKVVDEYVCRK--------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt4b ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--P--TVSSVT------------------------------------------------------------------------------LTGRL-LLLLLWAAHLAMA---------TNW---------------------------LSLARLSRSR----PVS------------------------GAEPC--GR---L--RGLS-----P-G-QVGVC------RARGEVM-E-SVRKASEMVIEECQHQFRNRRWNCSTT-----------------------------------PRGINVFG--R--V---MNQ-------------------------G-TREAAFVHALSSAAVAVAVTRGCSR-GEL-ERC-G-C-DRKV-----------------------------RG--VSPE---------------------------------------------G--------F-------QWSGC-SD-NLSYGVAFSQTFVD-EPE-----RAK---------------------------------------------GMSSGRPLMNIHNNEAG-RK----AIL--HNMQVECKCHGVSGS-----CELRTCWKVMPPFRRVGAVLKEHFDGATEVRLTRV------------GSRTAL-LPRDPQ-----------------------------------------------------------------------------------VKPPATR-D-LVY-LAPSP-DFCRLDPDN-GIPG----TAGRRCNG-T------------------------------SRLAPDG-CELLC--CGPGFRAGRAEVVQ-RCSC-KFS------WCC--SVRCQQ-CKNTVLIHTCRE--------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--I--ALKIV-------------------------------------------------------------------------------------ILTQLVMASLVYS---------SQW---------------------------LSLALTGSNP---NRFL------------------------SKKNC--DE---I--GQLS-----NHR-QVQVC------KRNIQVM-D-SVKDGASVALFECQHQFRYRPWNCTTV------------------------------Q----FSRSPVFG--N--S---ING-------------------------G-TREAAFVHAISSAGVAYAVTQACSS-GRLGQKC-G-C-DRKT-----------------------------RG--Q-AD---------------------------------------------G--------F-------NWGGC-SD-DIDFGMTFATRFVD-ARE-----RGS--------------------------------------------GIGSPARVLMNLHNNRGG-RL----AVR--KFMDLQCKCHGVSGS-----CNIKTCWRALPNFRIVGDYIKEKFDGATEVEYKLI------------GGKHVL-VPKNRK-----------------------------------------------------------------------------------YKPHTQM-D-LVY-LVQSP-DFCEPNPKT-GSLG----TQGRICNR-T------------------------------SQ-AIDG-CDLMC--CGRGYVSRTEVRQE-QCAC-KFF------WCC--HVRCQT-CMRRVEVSYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--R--ARPQVC--------------------------------------------------------------------------------EAL-LFALALQTGVCYG---------IKW---------------------------LALSKTPSAL----ALN------------------------QTQHC--KQ---L--EGLV-----S-A-QVQLC------RSNLELM-H-TVVHAAREVMKACRRAFADMRWNCSSI------------------------------------ELAPNYL--L--D---LER-------------------------G-TRESAFVYALSAAAISHAIARACTS-GDL-PGC-S-C-GPVP------------------------------GE-P-PGP--------------------------------------------G--------N-------RWGGC-AD-NLSYGLLMGAKFSD-APM-----KVK--------------------------------------------KTGSQANKLMRLHNSEVG-RQ----ALR--ASLEMKCKCHGVSGS-----CSIRTCWKGLQELQDVAADLKTRYLSATKVVHRPM------------GTRKHL-VPKDLD-----------------------------------------------------------------------------------IRPVKDS-E-LVY-LQSSP-DFCMKNEKV-GSHG----TQDRQCNK-T------------------------------SN-GSDS-CDLMC--CGRGYNPYTDRVVE-RCHC-KYH------WCC--YVTCRR-CERTVERYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt11r ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-KR--TFPSLP---------------------------------------------------------------------------------LC-LLTFLLLSQQCTG---------IRW---------------------------LALSQTAQ------HIN------------------------KTQHC--KT---L--PGLV-----S-S-QAQLC------RSNLELM-Q-TIIQAAREVKKVCQKTFTDMRWNCSSI------------------------------------D-GPKFL--P--D---LER-------------------------G-TRESAFVYALSAAAISHTIARACTS-GDL-RLC-S-C-GPIP------------------------------GE-I-PEP--------------------------------------------G--------Y-------RWGGC-AD-NIHYGLLMGSKFSD-APM-----KMK----------------------------------------K---KSGSHANKLMHLHNSEVG-RQ----ALR--DALVMKCKCHGVSGS-----CSIRTCWRGLLDLKDIAIDLKTKYLSATKVVHRPM------------GTRKQL-VPKDID-----------------------------------------------------------------------------------IRPVREN-E-LVY-LQSSP-DYCMKNDKL-GSFG----TQDRQCNK-T------------------------------SS-GSDS-CDLMC--CGRGYNPYTERVVE-RCHC-KYH------WCC--YVTCKK-CDKTVEKYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--T--EYRNFL---------------------------------------------------------------------------------LL-FITSLSVIYPCTG---------ISW---------------------------LGLTINGSSV----GWN------------------------QTHHC--KL---L--DGLV-----P-D-QQQLC------KRNLELM-H-SIVRAARLTKSACTSSFSDMRWNCSSI------------------------------------ESAPHFT--P--D---LAK-------------------------G-TREAAFVFSLAAAVVSHAIARACAS-GDL-PSC-S-C-AAMP------------------------------SE-Q-AAP--------------------------------------------D--------F-------RWGGC-GD-NLRYGLQMGSAFSD-API-----RNR--------------------------------------------RSGPQAFRLMQLHNNAVG-RQ----VLM--DSLEMKCKCHGVSGS-----CSVKTCWKGLQDISTISADLKSKYLSATKVIPRQI------------GTRRQL-VPREME-----------------------------------------------------------------------------------VRPVGEN-E-LVY-LVSSP-DYCTQNAKQ-GSLG----TTDRQCNK-T------------------------------AS-GSES-CGLMC--CGRGYNAYTEVLVE-RCQC-KYH------WCC--YVSCKT-CKRTVERYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--D--FTPAL----------------------------------------------------------------------------------WV-ILLVMFIDGRSSA---------IKW---------------------------LSIADVGKNL----SWN------------------------KTSSC--RK---V--SGFV-----P-E-QTQLC------RRTLEVM-P-AVEYAAESARKTCQEQFGNRRWNCSSI------------------------------------KKAPHFM--N--D---LEK-------------------------G-TKEAAYVHALSSAAVVHTVARACAA-GYL-KAC-T-C-ARNP------------------------------GE-K-PD---------------------------------------------G-------NY-------TWGGC-GD-NVKFGLEFGSRFAD-APM-----RKK---------------------------------------------KRSHTQTLMNLHNSEAG-RL----AVQ--NTMTTKCKCHGVSGS-----CNVKTCWKSLADLTEISHELAEKYSYAIKVVKRKI------------GTRQQL-VPEDRR-----------------------------------------------------------------------------------SRRHGSG-D-LIF-VENSP-NYCMVNNRK-GSYG----TTGRLCNK-T------------------------------SV-GPDS-CQTMC--CGRGYNDFTVTVTE-RCNC-KYH------WCC--YVTCDQ-CTRTEKKYMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLS--FTPVL----------------------------------------------------------------------------------WM-VLLLMFFDGRSSA---------IKW---------------------------LSIADVGKNL----SWN------------------------KTSSC--RK---V--SGFV-----P-E-QTQLC------RRTLEVM-P-AVEYAAEAARKTCQEQFGNRRWNCSSI------------------------------------KKAPHFM--N--D---LEK-------------------------G-TKESAYVHALSSAAVVHTVARACAA-GYL-TAC-T-C-ARNP------------------------------GE-K-PD---------------------------------------------G-------NY-------TWGGC-GD-NLKFGLEFGRRFAE-APM-----RKR---------------------------------------------KRSHTQTLMNLHNSEAG-RL----AVQ--NTMTTKCKCHGVSGS-----CNVKTCWKSLADLTEISHELAEKYSYAIKVVKRKI------------GTRQQL-VPEDRV-----------------------------------------------------------------------------------SRKHGSG-D-LIF-VDNSP-DYCIRNNRK-GSYG----TTGRLCNK-T------------------------------SV-GPDS-CQSMC--CGRAYNEFTTSVTE-RCNC-KYH------WCC--YVTCDQ-CTRTETKYMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--D--FTPVL----------------------------------------------------------------------------------WG-ILLLVFIDGRSSA---------IKW---------------------------LSIADVGKNL----SWN------------------------KTSSC--RK---V--SGFV-----P-G-QTQLC------RRTLEVM-P-AVEYAAEAARKTCQEQFGNRRWNCSSI------------------------------------KKAPHFM--N--D---LEK-------------------------G-TKEAAYVHALSSAALVHTVARACAA-GYL-KAC-S-C-ARKP------------------------------GE-K-PD---------------------------------------------G-------NY-------TWGGC-GD-NVKFGLEFGTGFAD-APM-----MKR---------------------------------------------KRSHTQTLMNLHNSGAG-RL----AVQ--NTMTTKCKCHGVSGS-----CNVKTCWKSLADLTEISHELAEKYSYAIKMVKRKI------------GTRQQL-VPEDRR-----------------------------------------------------------------------------------SRRHSSG-D-LIF-VDKSP-DYCIVNNRK-GSYG----TTGRLCNK-T------------------------------SV-GPDS-CQTMC--CGRGHNDFTTTVTE-RCNC-KYH------WCC--YVTCDE-CTRTEVKSMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVWSLSSTVTV----------------------------------------------------------------------------------LVFATLMTTSLHSSYA---------IQW---------------------------LALAGHEPKL----YWN------------------------QTSSC--RR---AK-AGMV-----S-A-QKKIC------RQELDSM-E-GIVEAAELTKQTCVKQFADRRWNCSSI------------------------------------NTAPDFT--P--D---LDK-------------------------G-TREAAFAYALAAAAISYSMAIECSS-GAI-SKC-G-C-GRTP------------------------------PE-E-AD---------------------------------------------A-------DF-------HWGGC-SD-NVGYGMSFSARFAD-APL-----RTK--------------------------------------------RKRNQPESLMGLHNNQAG-LL----TVQ--ENMKRKCKCHGVSGS-----CNVKTCWQSLPEMEEIGSKLKRKYAGATEVVSEKV------------GNRYNL-VPVDTN-----------------------------------------------------------------------------------LKKFTEQ-D-LIY-LTNSP-DYCRQNEKT-GSLG----TVGRFCNK-T------------------------------SI-GNDG-CDLMC--CGRGYKSMVITIVE-QCQC-RYH------WCC--YVKCKE-CSRTAEVQVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----S-----------------------------------------------------------------------------------------------------------------------------------------------GLRTASE------HWN------------------------RTADC--VK---AKEHGLV-----K-Q-QIQIC------KRNMELM-P-VVAHATRQTTDVCQYLFAQYRWNCTSV------------------------------------RMAPKYL--P--D---LTG-------------------------G-SREQAYVHALSAAALAQTISKACTQ-GAT-TKC-S-C-GRIP------------------------------NE-A-PP---------------------------------------------S-------EF-------KWGGC-GD-DLRFGMIFSASFAD-SPF-----LKR---------------------------------------------KKRSKQAMMNLHNNNAG-RK----IIS--DSLVTDCKCHGVSGS-----CNIKTCWKALPDMRTVGTKIQERYRLAVEVVNKKVKN----------SKERRF-VPLMDK-----------------------------------------------------------------------------------KTSFSEN-E-LIY-YTKSP-DYCLPDGGL-GSMG----TRGRECEK-T------------------------------ND-GSIG-CQSMC--CGRGFTSQVVEVKH-RCEC-KYF------YCC--YVECKT-CTKKVEINRCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt11 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KHK----TWE------------------------NPKMC--SK---A--LGLL-----P-R-QRRIC------KQHLEIM-S-TIVGASLLSVETCQNQFSDRRWNCSSI------------------------------------SQVPSVP--R--D---LSR-------------------------G-TREQAYVYGIASAALTHSVARACSI-GVT-RKC-S-C-GALP------------------------------NT-A-PT---------------------------------------------G-------AF-------KWGGC-GD-DLHFGMALGRAFTD-ASL-----KSK---------------------------K------------G---KSKSSKKAMMNRHNFAAG-RK----IVE--SSLTTACKCHGVSGS-----CSIKTCWKSLPDFDSIGATLKNRYALAVEVKRKRKK-----------K-QKVL-VPIMKN-----------------------------------------------------------------------------------KKTIRSD-E-LIY-YTKSP-DYCSPDAKS-GSIG----THNRLCDK-T------------------------------SR-GSGG-CDVMC--CGRGYDSFKMEVME-RCEC-KYY------WCC--YVKCKT-CVKTLNLSKCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------YSL--------------------------------------------------------------------------------FGLF-VVLCLSFWSPVVT---------IRW---------------------------LGIRHTSQH-----TWD-------------------------KKDC--NR---I--HGFS-----G-K-QYKIC------RRNLPAM-L-YVTAAVEMTREECQHQFQNKRWNCSTI------------------------------------VKAPQFL--P--D---LKR-------------------------G-TPEAAFVYALSAAALTYSITQACGM-KRL-KPC-K-C-GTNP------------------------------KF-KHPD---------------------------------------------G----------------EWGGC-HD-NIARGMRFSKDFTD-AVE-----AQR---------------------------M------------R---KHKSMAVALMNLHNNGVG-RK----AVH--SRLEFHCRCHGVSGG-----CTAKTCIRRLGDFRLVADLLKNRYARIVYVESKTKS-----------KRKARV-LKSKRG-----------------------------------------------------------------------------------RRRYTSS-D-LVA-LQGSP-NYCHKNRKR-GTAG----THGRLCDP-T------------------------------KRRGEGS-CAYLC--CGRGHRTEEVVHEE-RCEC-KYI------WCC--YVKCQT-CRKRVRESRCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt11a ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--K------------------------------------------------------------------------------------------ISVTLFSGLLSAAFG---------IDW-----------------------------IGMHGK------MVE-------------------------DDLC---D-------GLS---DTL---QYRLCSKFSKDRKTKGFM-E-AIHTATIQTTTACSSAMAKNRWNCESL------------------------------------KSAPKFK--R--D---LRK-------------------------G-TSERAFVHALSSAAVSINIANRCAR-GDM-GMC-G-C-RYRP-----------------------------QDE-Y-----------------------------------------------LD-------PT-------VSKPC-EH-DLKWANEFSKQWTD-API-----L-R--------------------------------------------SDAKNRYQRMFTADNNAG-RE----VAL--QSMRTVCKCHGVSGS-----CTEKTCWKVSPTVEEVAESLKNLYESSVRLP------------------KRRR-NDESNR-----------------------------------------------------------------------------------VERSSVV-Q-MYY-VDKSN-DFCEADRRT-GSAG----TAGRTCDP-N------------------------------SF-GE-GSCDKLC--CGRGHKKVIETTINENYNC-RYV------WCC--RVECDT-VKETTVTHICK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt11d ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--K------------------------------------------------------------------------------------------I--TFFS-LFASITG---------LSW-----------------------------LGLH-R------YN-------------------------HEDICEF-E-------GLT----RP---QKRLC-----QKYPK-FQ-P-ALKAASLSTINLCKSSMKGHLWGCKGA------------------------------------DKLPAIG--P--E---LSE-------------------------A-TSESAFVHALGAGQLLAALKTICRT-GAS-GSC---------------------------------------------------------------------------------------------------------------------DEDELRMFAIQFTD-VLA-----MS---------------------------------------------RRAKGQ-KTVELHNNDVG-RS----TAD--RHSRLVCKCHGQSGS-----CTQKTCWRGSPDPEKVATELSTKYESAAKV-------------------RAQ---DELPA-----------------------------------------------------------------------------------IFRQYVVRDRLLY-IKNSI-NHCEI-------------TKGRECNP-Y------------------------------SS-EK-SSCERLC--CGRGFITRLHKEPRRECKM-QTIEVDGSLWPA--GITCKT-VYDSSISHSCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt11b ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--R------------------------------------------------------------------------------------------ISNILFA--FTEASS---------LSW-----------------------------IGL--R------SW-------------------------TDDICSF-N-------GLT----TQ---QARLC------RQNEFIA-P-AIKSAAEIATEACVNSMSDTLWGCNGI------------------------------------KSLPKEQ--P--E---LAQ-------------------------P-TQESAFLHALANGHLKNALEKFCKK-G-S-ADC---E-RFNP-----------------------------------------------------------------------------------------------------------------EQFSLEFSD-VAA------------------------------------------------------FKKKHFLFGLHNNKIG-RQ----AAD--DAKNTICKCHGPSGS-----CTQKTCWKATTNTAKLTKIVKEKYESAARIH------------------QRQL-EILPQG-----------------------------------------------------------------------------------VFSSLIS-DRLIF-GKKSP-NFCEI-------------TRGRVCDATK------------------------------SY-GP-GSCEELC--CGRGSLQKIIIETEEVCTM-QFVKIEGTSWPV--GVTCKD-MFYQKTTSTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt11c ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--K------------------------------------------------------------------------------------------IFNVLFA--FSEASS---------LSW-----------------------------IGL--R------SW-------------------------TGDICSF-S-------GLT----SQ---QANLC------RRSSFVA-P-AIKSAAETATDACLNSMSDTLWGCNGI------------------------------------KSLPKEQ--P--E---LSQ-------------------------P-TQESAFLHALATGHLKNALEKFCRK-GGK-ADC---------------------------------------------------------------------------------------------------------------------DKFNHEQFALEFSD-VAA------------------------------------------------------FEKKHFLFGLHNNKVG-RQ----AAD--QAKNTICKCHGPSGS-----CAQKTCWKASTNTAKMNKIIKEKYESAAKVP------------------VRQL-EILPQG-----------------------------------------------------------------------------------VFSSLIS-DRLIF-GKTSP-NFCEV-------------TRGRVCDATN------------------------------SS-GA-GSCEEIC--CGRGSIQKISIETEEVCTM-EFVKIDGTTWPV--GVSCKD-EFYQKTTSTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--K-LQ-TLILYLGNPALHNA---------------------------------------------------------LGRQISCFPRQLLRWT-LCLHFAVIGIAAG---------IQW----------------------------SIGKTASISANPSLSL------------------------YNGWC---T-------GRAY--LTP-K-QRKIC------RHHYSMM-T-SVADAAQIALEECQTQFQSERWNCSTP--------------------------PHP-R----RQKRSVFG--R--E---LLT-------------------------G-TRELSFVYALSSAAVAYAITRDCRL-GKI-VGC-G-C-DQTW------------------------------AS-RAPLN-------------------------------------------HT--------F-------DWGGC-SD-NIRWGIEMSKLFVD-AQEFERERRNR---------------------------V--K-RRR-----R---KKREINERTVNLSNNKFG-RE----VIL--ANMGKRCRCHGISNS-----CEAMTCWRTLPSFRKVGEILKQSYDNAVQVHVVKKY-----------G-RYIL-RPRNRE-----------------------------------------------------------------------------------RHSVGHR-F-LSF-LRMSS-DFC-A-------------TTGRTCEP-D------------------------------ET-GPNG-CDEMC--CERGYVIKTRHVTT-KCGC-TFT------WCC--NVTCHA-CNETRIEHVCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--K-IQ-TILLLLSNPRLCRV---------------------------------------------------------LGRQFNKFSRNIFRRI-LCVHFAIFGIATG---------IQW---------------------------LSIGKTFSVGSQPTLSL------------------------YNGWC---V-------EREY--LTP-R-QQKIC------RRHYSMM-T-SVADAAQMALKECQKQFETERWNCSTP--------------------------PQP-R----RHRRSVFG--R--E---LLS-------------------------G-TRERSFVYALSSAAVAYAITRDCSL-GNI-VGC-G-C-DQTW------------------------------PQ-RAPFN-------------------------------------------QS--------F-------DWGGC-SD-NIRWGVEMSKLFVD-AQEYERGRQKR---------------------------IGRN-RRR-----R---RKREINERTVNLNNNKFG-RE----AIL--SGMGKKCRCHGISNS-----CESMTCWRTLPSFRKVGRILKRSYSTAVQVHIVKKY-----------G-RYLL-RPRDRD-----------------------------------------------------------------------------------RRSVGNR-Y-LAF-LRMSS-DFC-A-------------TTGRTCDA-D------------------------------KS-GPSG-CDVMC--CGRGYVIKTSYVTA-KCGC-KFS------WCC--DVTCKS-CNETRVEYVCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-HKMVQRKFK---------------------------------------------------------------------HRKFTCW-MNIVQCW-IILHFGFFGITSA---------IQW---------------------------LSLGKIMSVGP---ETR------------------------SMLFC---D-------RSYY--LTP-R-QRKFC------RQYSGTM-A-SVAQAASLAMKECRRQFVNEPWNCSTPYR------------------------RHW-N----HMRG---------------------------------------------------ALSSAAVAFSVAKDCKN-GRI-NRC-G-C-DGTW------------------------------DK-YAPTT-------------------------------------------GG--------F-------SWGGC-SA-NIDWGKHMSRMFTD-VPR-----KRR---------------------------MRRN-TRK-----S---RKRRRNENHVNFYNNNFG-RK----KLM--ERMGRKCKCHGPTGS-----CQQQTCWRSLPNFEEIGATLKRNYAEAQQVHVVRTRD----------G-RTLV-RPKQ-------------------------------------------------------------------------------------LSHRWKE-T-LAY-LRKSP-AFC-R-------------TAGRKCSL-G------------------------------AN-GPAG-CKTMC--CGRGYTNRTVVERN-SCQC-SFQ------WCC--SVSCKDVCVKEHVEQYCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt11 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---M-QRNCK---------------------------------------------------------------------NRKLS-L-LYLLECW-LVLHFGLFGLSSA---------IQW---------------------------LSLGKIMSVGS---GTR------------------------SMLFC---D-------RNYY--LTT-R-QRKFC------RQYSGTM-A-SVAQAASLAMNECRRQFSNEPWNCSTPYR------------------------RHR-N----RVKEAAPP--A--G---VSA-------------------------G-SRESAYVHAISSAAVAYSVAQDCKN-GRI-DRC-G-C-DGTW------------------------------GE-YAPRN-------------------------------------------GG--------F-------SWGGC-SP-NIDWGKHMSRMFTD-VPR-----KRR---------------------------MRRN-TRK-----S---RKRRRNENHVDFYNNNFG-RK----KLN--ERMGRKCKCHGPTGS-----CQQQTCWRSLPKFEELGATLKRNYAEAQQVHVVRTRD----------G-RILV-RPKR-------------------------------------------------------------------------------------LSHRWKE-S-LAY-LRKSP-TYC-K-------------TTGRKCAL-G------------------------------TN-GPGG-CETLC--CGRGYRNKTIVERN-SCKC-SFQ------WCC--SVSCTDVCVQERVEQYCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt11 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRFCRTASHIADRHVVI------------------------TRKWC---K-------RTPG--LAS-G-QRKIC------KDHTMSM-P-AIISATKLAIKACQIQMADRDWNCTV-------------------------------------ESTGRFR--H--A---PKS-------------------------G-SRESALIHALGSSAIAFTLSKYCSR-GLI-SDC-G-C-VEDP------------------------------GA-EVEEN-------------------------------------------SA--------F-------AWSGC-SD-NVAVGVAFAQAFMK-SWDLSLWRTKQ---------------------------LS-NKDKG-----S---RWKKLGKILANLRNNAAG-TN----ILH--QSLRKNCACHGMTGS-----CEVTTCWRSLPPFAVIAKSLKIKYDKAIRVRLRKSHF----------G-DGAF-QPINRS-----------------------------------------------------------------------------------LNDIKKG-D-LIF-LRRPK-KFC-E-------------TRGRECMP-Y------------------------------SF-GLGS-CDDLC--CNRGFQTRTQIIST-RCRC-RFV------NCC--RVDCDS-CCSEVLVHVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt11 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQF---------------------------RSLGFHKDKR----NIT------------------------SKDWC-----------KMEA--LAN-K-QRKVC------KRHTSSM-V-AIVASTALTLHECQKQLRDRDWNCSVT------------------------------------NTRKIFQ--P--I---LKS-------------------------G-SRESAFVYALSSAAVAFMITKYCSS-GMI-EDC-E-C-DATW------------------------------KK-NAPKN-------------------------------------------AA--------F-------QWSGC-SD-NIAWGEQFSREFLD-VWQTPT--KRK---------------------------IA-NKNNNRYGRQS---YRHNEAKILFKEKNNDVG-RE----EVS--SRMKRRCACNGLSGG-----CEITTCWQSLPEFFEIAAALKKKMDSAVKVKLQRTN-----------G-RRFF-VNSHSGK----------------------------------------------------------------------------------TKIVKTE-D-LVF-LRNMK-RTC-V-------------TKGRRCDP-Y------------------------------LI-KYGS-CDHLC--CGRGFKALIKVETF-QCRC-KFF------WCC--EVRCEK-CKKNVSANICL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt11 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQF---------------------------RSLGFPNDKR----NIT------------------------TKDWC-----------KMEA--LAH-K-QRKVC------KRHTSSM-E-AIVASTALTLHECQKQLRDRDWNCSVT------------------------------------NTKKIFQ--P--I---LKS-------------------------G-SRESAFVYALSSAAVAFMITKYCSS-GMI-EEC-E-C-DATW------------------------------NK-KAPKN-------------------------------------------SA--------F-------QWSGC-SD-NIAWGEQFSREFLD-VWQTPT--KRR---------------------------IT-NKNSNIYGRQW---YRHNEAKILFKEKNNDVG-RE----EVS--SRMKRHCACNGLSGG-----CEITTCWRSLPEFFEIAAALKKKMDSAVKVKLQRTS-----------G-RRFF-VNSHSGK----------------------------------------------------------------------------------TRIVKAE-D-LVF-LRNTK-RTC-V-------------TKGRHCDP-Y------------------------------LI-KYGS-CDQLC--CGRGFKALIKVETF-QCRC-KFF------WCC--EVRCEN-CKKNVSVNICL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------RVLALL----------------LA-VK-AACVLLVSSL----------------------------------------------------------------------------------------TGTGAVNNSG---------RWW-GI------------------------VNVASSGNLL--TNSK-------------------------NVQLV--LD----P-SLALLSR----R-QRKLI------RQNPGIL-H-AIAAGLHTAIKECKWQFRNRRWNCPTT------------------------------------HSPNVFG--K--I---VNR-------------------------G-CRETAFVFAITSAGVTHAVARSCSE-GAI-ESC-T-C-DYR-------------------------------RR-G-PGG-------------------------------------------PD--------W-------HWGGC-SD-NVEFGRMFGREFVD-SSE----------------------------------------------------RGRD-LRYLTNLHNNEAG-RM----TVA--SEMQQECKCHGMSGS-----CTVRTCWMRLPSFRLVGDYLKDRFDGASRVVYANKGS-NRASHRAD---PRHL-EPENPAH----------------------------------------------------------------------------------KLPS-SR-D-LVY-FEKSP-NFCSYNGKT-GTHG----TSGRTCNS-S------------------------------SP-ALDG-CELLC--CGRGYKTRMEQVTE-RCHC-TFH------WCC--HVSCLN-CTSTQTVHQCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------GLWALL----------------PGWVS-ATLLLALAAL----------------------------------------------------------------------------------------PAALAANSSG---------RWW-GI------------------------VNVASSTNLL--TDSK-------------------------SLQLV--LE----P-SLQLLSR----K-QRRLI------RQNPGIL-H-SVSGGLQSAVRECKWQFRNRRWNCPTA------------------------------------PGPHLFG--K--I---VNR-------------------------G-CRETAFIFAITSAGVTHSVARSCSE-GSI-ESC-T-C-DYR-------------------------------RR-G-PGG-------------------------------------------PD--------W-------HWGGC-SD-NIDFGRLFGREFVD-SGE----------------------------------------------------KGRD-LRFLMNLHNNEAG-RT----TVF--SEMRQECKCHGMSGS-----CTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGS-NRAS-RAE---LLRL-EPEDPAH----------------------------------------------------------------------------------KPPS-PH-D-LVY-FEKSP-NFCTYSGRL-GTAG----TAGRACNS-S------------------------------SP-ALDG-CELLC--CGRGHRTRTQRVTE-RCNC-TFH------WCC--HVSCRN-CTHTRVLHECL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------KFCYL--------------------II-ICLYPTLSLG----------------------------------------------------------------------------------------TGKAQGTTTG---------KWW-GV------------------------ASSQQKSNLV--VNRA-------------------------GVPVV--VD----Q---TPLNK----K-QRKLI------RLHPGSL-S-AITNSVGMSKTECKWQFKERRWNCPTN---------------------------KN-D----RGGRNLFG--N--I---LES-------------------------G-CRETAFIYAITASAVAHSVARSCSE-GSI-ETC-N-C-DYE-------------------------------KR-G-KGG-------------------------------------------KG--------W-------EWGGC-SD-NADFGSNFSRKFVD-AGE----------------------------------------------------KGRD-LRYYMNKHNNAAG-RR----IVT--DNMRRECKCHGMSGS-----CQVKTCWMRLPTFREVGDILKERFDGASQIAQTNNGH-NRGTRRKK--RIKHF-ESADPQH----------------------------------------------------------------------------------KHPT-AS-D-LVY-FEESP-DFCELNKKV-GSLG----TRGRQCNN-T------------------------------SI-GIDG-CDLLC--CERGYRSEIEQVTE-RCSC-TFH------WCC--QVKCET-CVTQRTVHTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------KLVCT--------------------LW-ALLFLVLAAA----------------------------------------------------------------------------------------PVARVHAVIG---------RWW-GIAST---------------------VAVQEHANMVPGVARK-------------------------GSAIM--LD----P-KKHPLNK----K-QRRLV------RRNPGTL-E-SIGTGAMLAIKECQHQFSNRRWNCPVN---------------------------TN-D-----HVNSVFG--N--I---LKR-------------------------G-CRETAFIYAVMSAAVAHEVGRNCAE-GTI-ETC-S-C-DYR-------------------------------SK-G-PAG-------------------------------------------ED--------W-------EWGGC-SD-NVEFGKQFAKQFVD-AGE----------------------------------------------------KTKDSVRYLVNMHNNEAG-RV----AVA--ENLRRECKCHGMSGS-----CTLKTCWMRLPNFRDAGDSLKEKFDGASKVAVPDIGN-NRGS-RAK---VTGL-VPKNSRH----------------------------------------------------------------------------------KFPT-DN-D-LVY-HERSP-NFCRNNPRL-GFEG----TRGRECNV-T------------------------------SR-GLDS-CDLLC--CGRGYATRQEVTKE-RCNC-TFQ------WCC--QVKCEE-CVRTKTIHTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------KLVCT--------------------FW-VVLFLWLAVA----------------------------------------------------------------------------------------PMERVHAVIG---------RWW-GIAST---------------------VAVQEHANMVPGVPRK-------------------------GSAIM--LD----P-KKHPLNK----K-QRRLV------RRNPGTL-E-SIGTGAMLAIKECQHQFSNRRWNCPVD---------------------------TN-D-----HVNSVFG--N--I---LKR-------------------------G-CRETAFIYAVMSAAVAHEVGRNCAE-GTI-ESC-S-C-DYR-------------------------------SK-G-PAG-------------------------------------------ED--------W-------EWGGC-SD-NVEFGKEFAKQFVD-AGE----------------------------------------------------KTKDSVRYLVNMHNNEAG-RV----AVA--ENLRRECKCHGMSGSCTLKTCTLKTCWMRLPNFRDVGDSLKEKFDGASKVAVPDIGN-NRGS-RAK---VTGL-VPKNSRH----------------------------------------------------------------------------------KYPT-DN-D-LVY-HERSP-NFCRNNPRL-GFEG----TRGRECNV-T------------------------------SR-GLDG-CDLLC--CGRGYATRQEVTKE-RCNC-TFQ------WCC--QVKCEE-CVRTKTIHTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------KLVCT--------------------FW-AVVLLFLAVV----------------------------------------------------------------------------------------PVERVHAVIG---------RWW-GIAST---------------------VAVQEHANMVPGVARKP------------------------GSTIM--LD----P-KKHPLNK----K-QRRLV------RRNPGDAGE-HRDRRPMLAIKECHHQFSKWRWNCPVN---------------------------TS-D-----HVNSVFG--N--I---LLR-------------------------G-CTQTAFIYAVMSAAVAHEVGRNCAE-GTI-ETC-S-C-DYR-------------------------------SK-G-PAG-------------------------------------------ED--------W-------EWGGC-SD-NVEFGKQFAKQFVD-AGE----------------------------------------------------KTKDSVRYLVNMHNNEAG-RV----AVA--ENLRRECKCHGMSGS-----CTLKTCWMRLPNFRDVGDSLKEKFDGASKVAFPDIGN-NRGS-RAK---VTGL-VPKNSRH----------------------------------------------------------------------------------KFPT-DN-D-LVY-HERSP-NFCRNNPRL-GFEG----TRGRECNV-T------------------------------SR-GLDG-CDLLC--CGRGYATRQEVTKE-RCNC-TFQ------WCC--QVKCEE-CVRTKTIHTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------NLYMF--------------------QM-LVIFVGMATLEV-----------------------------------------------------------------------------VTPGKG---GGKRSRTRGV---------KWW-NL------------------------AHTQHFMSDS--LLNP-------------------------ETPLF--IN----P-SLQPLTR----K-QRRLV------TRNPGTS-I-AIAKAARMAVDECQRQFSTRRWNCPV----------------------------YD-A----SHGSSIFG--K--V---VRK-------------------------G-IRECAFIYAIMSAALAHSIARSCAE-GSI-YTC-T-C-G-RH------------------------------SR-R-LANSVQP---------------------------------------RD--------W-------EWGGC-SD-NAEFGRKFSHDFID-VAE----------------------------------------------------KGRD-LKCLMNLHNSEAG-RT----QVS--SEMSKECKCHGMSGS-----CTVKTCWMKLPMFGRVGKVVKDRFDGASQVEQGN-GAINR-S-K----NRFNL-IPINTNH----------------------------------------------------------------------------------KPPE-PK-D-LVY-FERSP-TFCTKDPSI-GHTG----THGRPCNA-S------------------------------SI-GVEG-CDLLC--CGRGYRSELYTARE-RCNC-IFH------WCC--KVTCDT-CTKTKVRHICL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt1 -----------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SATFFGNFSC---------R---SL------------------------AKMGHRTND---LRTS-------------------------VTQLY--NN----P-SLLPLTK----K-QKKLV------TRNPGSI-M-AIAKGAKMAIDECKYQFKNRRWNCPT----------------------------YV-D----GHGGSIFG--K--I---LNT-------------------------G-CRETAFIYAATSAAVSHSIARACSE-GSI-HTC-S-C-DFEH------------------------------NK-V-PVG-------------------------------------------KD--------W-------EWSGC-SD-NARYGHKFSRRFVD-VLE----------------------------------------------------KGRD-FRYMMNLHNNEAG-RV----HVS--SGMKQECKCHGMSGS-----CTIKTCWMRLPPFRNIGHILKDRFDGASKVLPGNTGRA-V--KRKR--RRFNF-SPVNPNH----------------------------------------------------------------------------------KRPG-RR-D-LVY-FEHSP-TFCEKENMI-GFEG----TAGRECNS-T------------------------------SL-GVNG-CDLMC--CGRGYKSETFPVKE-RCHC-TFH------WCC--QVKCQV-CTRLKVRNTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt1 -----------------------------------------------------------------------------------------M-------------------------------------DINRSDS-RDVC-TTKRHPR--VRTSSSYKRFFA--SSSLL---KIFLLMYVFALVM--KSCESS--AKWWSIMHVPSIESLEITTDASSDMSTKRHYRRSGLQPSTITQQNS--------NTDLYSRLRDINI--DDAKNLLSDETIREILSGTDPSTVGNSGSFGGFIRSQITNERYE---------RRD-DSNKKSRRR-----------------ERILTNGNAI--GSNI-------------------------GRPTL--AD----H-RIQPLNK----K-QRRMM------RRNPGAM-A-EIIRGIRRAVHECKFQFRNRRWTCPT-------------------------------D----SNDSTLFG--K--I---LNN-------------------------G-FRETAFIYAITSAAVSHAVAKGCSE-GTI-ETC-G-C-DDK--------------------------------S-G-PGG-------------------------------------------PG--------W-------EWGGC-SD-NLRFGRKFAKDFVD-AAE----------------------------------------------------VGRD-LKYRMNLHNNEAG-RM----TVN--EKAVRHCKCHGLSGS-----CTVQTCWLRVGDFHEIGRRIREKSDSATEVTISNQGSI-K--EG-----EDDL-VPVH-GE----------------------------------------------------------------------------------KAPR-KQ-D-LVY-FENSP-SFCSRDTEF-WIEG----TRGRTCNA-T------------------------------SN-GYNG-CDSMC--CGRGYRTRQKTVRQ-RCKC-VFQ------WCC--NVKCDV-CETVKEVSVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt1 -----------------------------------------------------------------------------------------M-------------------------------------DNNGSDS-RDVC-TTKRHPR--VRASSSYKRFFA--SSSLL---KVFLLMYVFALVM--KSCESS--AKWWSIMHVPSIESLEITTDASSDMSTKRHYRRSGLQPSTITQRKS--------NTDLYSRLRDINI--DDAKNLLSDETIREILSGTDPSTLGNSGSFGGFIRSQVTNERYE---------RRD-DSNKKNRKR-----------------ERILTNGNAI--GSNI-------------------------GRPTL--AD----H-RIQPLNK----K-QRRMM------RRNPGAM-A-EIIRGIRRAVHECKFQFRNRRWTCPT-------------------------------D----SKDPSLFG--K--I---LNN-------------------------G-FRETAFIYAITSAAVSHAVAKGCSE-GTI-ETC-G-C-DDK--------------------------------S-G-PGG-------------------------------------------PG--------W-------EWGGC-SD-NLRFGRKFAKEFVD-AAE----------------------------------------------------VGRD-LKYRMNLHNNEAG-RM----TVN--EKAVRHCKCHGLSGS-----CTVQTCWLRVGDFHEIGRRIREKSDSSTEVTISNQGSI-K--EG-----EDDL-VPVH-GE----------------------------------------------------------------------------------KAPR-KQ-D-LVY-FENSP-SFCSRDTDF-WIEG----TRGRMCNA-T------------------------------SN-GYNG-CDSMC--CGRGYRTRQKTVRQ-RCKC-VFQ------WCC--NVKCDV-CETVKEVSVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIASIPLSQRRSANA--RRQYSHQTTPPSRRKAPHS--------ETN------QADL--EEIESFLTNDKIKEILTSSDIATSATSQGEGSFANQNKRDVTSG---------RIS-DV------------------------NTVRRADSIF----TK-------------------------SLSGN--FK----P-PIQLLNK----K-QRRLL------RRNKGAL-E-EIIAGLKRAVKECKYQFRNRRWVCQT-------------------------------D----SRDGSLFG--K--I---TAR-------------------------G-FRETAYIYAITSAAVTHSIARGCSL-GRI-ASC-G-C-DIR--------------------------------R-G-VGG-------------------------------------------PG--------W-------EWGGC-SD-NFKFARQFAKKFVN-AGE----------------------------------------------------VGTD-LKYRMNLHNNEIPYQQ----TVE--ESGKRFCKCHGMSGS-----CTLKTCLLRASDFRTVARKLRDKCDDAERVTTSNHGTI-G--KR----NS-GL-VPAVRGR----------------------------------------------------------------------------------KPPK-KV-D-LVY-FENSP-SFCVKEPEF-WAEG----TKGRTCNS-T------------------------------SN-GLNG-CESMC--CGRGFRTRVKTVRQ-KCNC-EFE------WCC--KVKCQI-CEVEKEISRCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt1 -----------------------------------------------------------------------------------------MFATEKSKSAHENYRIKYDGIKSKRKEKINKITNKSEGNINTSQTCPE-CWNIKKNCRKEPRKSRNVSKYFSTKSSNMFTAYQLLVIGHVILLLFQYKPCESSANGKWWNILNEISKELPEEEEPKQEDVV----YNPVIKVPSSGTMPHDFSSDNIDMKDNIYGELQELYLYDENGEEVLSEEAIFQILGQSSN----VGGAKLSSHSRRKRKGDAH---------KII-NSNSKRRRKYRKNDYKRKNRDVSDNKHGNVGLVNS---HENV-------------------------KAALL--LN----K-RILPLNK----K-QRRLL------RNNPGTT-E-QISRGVREAIEECKFQFRNRKWQCTT-------------------------------E----DNEENLFG--K--V---MDR-------------------------G-FREAAFVYAITSASVAHAVAQGCAE-GKI-ETC-G-C-DST-------------------------------IR-G-PGG-------------------------------------------KG--------W-------KWGGC-SD-NINFGMKFSREFVD-SGE----------------------------------------------------AGYD-LRYKMNVHNNEVG-RQ----VVK--DKTVKFCKCHGMSGS-----CTVQTCWLRVDDFRKVGKKLRDKYDHSIKVIQPNDGSL-T--KR----HSQKW-VMADHGV----------------------------------------------------------------------------------KPPR-KV-D-LVY-FENSP-DYCRRGSRL-WSGN----TSGRTCNA-T------------------------------ST-GPNS-CAEMC--CGKGYKIKEKTIKK-QCDC-DFK------WCC--KVRCKV-CHEKKRVTVCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt1 -----------------------------------------------------------------------------------------MFPTEKSKSAQENYQIKYDGIISKRKEKINKITNKSKGNINPSQTCRE-CWntKKNCRKELRKTRNVSKYFSTKSSNMFSAYKLLIMGHVILLLFQYKPCESSANGKWWNILNEISKELPEEDETKQEDDV----YNPLIKVPSSGTMTEDFISDNIDMKDNIYGELQELHLYDENGEEILSEEAIFQILGQGSN----VGGAKLSSHSRRKRKGDTH---------KIV-NSNSKRRRKYRKNDYKRKNRDVSDNKHGNAGLVNS---HENV-------------------------KAALL--LN----K-RILPLNK----K-QRRLL------RNNPGTT-E-QISRGVREAIEECKFQFRNRKWQCTT-------------------------------E----DDDENLFG--K--V---MDR-------------------------G-FREAAFVYAITSASVAHAVAKGCAE-GKI-ETC-G-C-DST-------------------------------IR-G-PGG-------------------------------------------KG--------W-------KWGGC-SD-NINFGMKFSREFVD-SGE----------------------------------------------------AGYD-LRYKMNVHNNEVG-RQ----VVK--DKTVKFCKCHGMSGS-----CTVQTCWLRVDNFRKVGKKLRDKYDHSIKVIQPNDGSL-T--KR----HSQKW-VTADHDV----------------------------------------------------------------------------------KPPR-KV-D-LVY-FENSP-DYCRRGSRL-WSGN----TSGRACNA-T------------------------------ST-GPNS-CAEMC--CGKGYKIKEKTIKK-QCDC-DFK------WCC--KVRCKV-CHEKKRVTVCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLNEVAEAYKDEN---KNEIA----SNIIPGFPSSEVISQDYLDDLNLGKDSLYAGLEDLAHLDENNNGVLTEEAIFRILESSNH----AGGAKLNRLNRQRRKGDSR---------RITPNGGSKKHLRIRKEEI-RRNRDVSHTLKTEALSRNTI--DKKF-------------------------HSSLF--VD----K-RINPLSR----K-QRRLL------RHNPGVT-E-EISRGIRSAINECKFQFRNRKWRCPT-------------------------------Q----PRDDTVFG--K--I---LDR-------------------------G-NRESAFVYAVTSAAVAHAVAKGCSE-GRI-ETC-G-C-DST-------------------------------MR-G-GGG-------------------------------------------NG--------W-------KWGGC-SD-NIDFGVKFSRDFVD-DAE----------------------------------------------------KGVD-IRYRMNLHNNEAG-RQ----AVK--DRTVKFCKCHGMSGS-----CTIQTCWQRVDDFRRVGRRLRDKYDSSVKITQSNEGNVFR--RR----YSNKW-ITVEKSA----------------------------------------------------------------------------------RAPR-KD-D-FVH-FENSP-DFCRKDPTL-WSEG----TSGRTCNA-T------------------------------ST-GPNS-CSEMC--CGRGYRIKEKVVKR-HCQC-DFK------WCC--KVRCKI-CQEEKRVNVCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt1 -----------------------------------------------------------------------------------------MQR---------------------------------------------------------------------------------------------------------FSAAILLVFMV-----------------------------------------------------------------------------------------SVCISNHEVQ---------GWW-NL---------------------------GFGFEDL--KNDY-------------------------NIQLS--PP----N-QIRALTQ----K-QIRIS------RRYPELI-Q-YIAGGARTAIHECQHQFRNRKWNCSA-------------------------------H----S-PENVFG--K--I---LKR-------------------------A-CRETAFTYAITAAGVSHAIARACGE-GKL-SAC-S-C-DQR-------------------------------YR-G-VSK-------------------------------------------QG--------W-------QWGGC-SD-NIHFADNFSKRFVD-AQE----------------------------------------------------KGRD-FRAQINLHNNEAG-RA----AVR--NNMMLECKCHGLSEA-----CTVKTCWKRLPDFRLVGDDLKAKFDDASMVEYQQNNN-NRNSNRNRNEDPALF-IPSKPYL----------------------------------------------------------------------------------RRPT-VY-D-LGY-YEHSP-NFCERNPSA-GSLG----TQGRECNT-T------------------------------SM-GTDG-CELMC--CGRGFTTSSQERVE-NCNCRVFL------GGC--EVKCQK-CKHEGSLSNCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN---------------------------------------------------APLGGIWLWLPLL---------LTWLT------------------PEVNSSWWYMR--------ATGGS------------------------SRVMC--DN----V-PGLVSS-------QRQLC------HRHPDVM-R-AISQGVAEWTAECQHQFRQHRWNCNTL-----------------------------------DRDHSLFG--R--VL--LR--------------------------S-SRESAFVYAISSAGVVFAITRACSQ-GEV-KSC-S-C-DPKK------------------------------M--GSAKDS------------------------------------------KG-------IF-------DWGGC-SD-NIDYGIKFARAFVD-AKE----------------------------------------------------RKGKDARALMNLHNNRAG-RK----AVK--RFLKQECKCHGVSGS-----CTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDG-------------TGFT-VANE--R----------------------------------------------------------------------------------FKKPTKN-D-LVY-FENSP-DYCIRDREA-GSLG----TAGRVCNL-T------------------------------SR-GMDS-CEVMC--CGRGYDTSHVTRMT-KCGC-KFH------WCC--AVRCQD-CLEALDVHTCKAPKNADWTTAT----------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT2b -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRPGGAEEAAQLPLRRASAP-------VPVPSPAAPDGSRA-----------SARLGLACLLLLL---------LLTLP------------------ARVDTSWWYIG--------ALG--------------------------ARVIC--DN----I-PGLVS------R-QRQLC------QRYPDIM-R-SVGEGAREWIRECQHQFRHHRWNCTTL-----------------------------------DRDHTVFG--R--VM--LR--------------------------S-SREAAFVYAISSAGVVHAITRACSQ-GEL-SVC-S-C-DPYT-------------------------------R-GRHHDQ------------------------------------------RG-------DF-------DWGGC-SD-NIHYGVRFAKAFVD-AKE----------------------------------------------------KRLKDARALMNLHNNRCG-RT----AVR--RFLKLECKCHGVSGS-----CTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDG-------------ANFT-AARQ--G----------------------------------------------------------------------------------YRRATRT-D-LVY-FDNSP-DYCVLDKAA-GSLG----TAGRVCSK-T------------------------------SK-GTDG-CEIMC--CGRGYDTTRVTRVT-QCEC-KFH------WCC--AVRCKE-CRNTVDVHTCKAPKKAEWLDQT----------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt2b.a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPECDG----------------------VGCASPARRDRQRARGGFLSRRERRGATQRIYLLFILL---------LLMFT------------------PSVDSSWWYIG--------ALG--------------------------ARVIC--DN----I-PGLVN------K-QRQLC------QRHPDLM-Q-SIGQGAKEWIRECQHQFRHHRWNCSTL-----------------------------------ERDHTVFG--R--VM--LR--------------------------S-SREAAFVYAISSAGVVYAITRACSQ-GEL-KIC-S-C-DSQR-------------------------------R-GRASDE------------------------------------------DG-------DF-------DWGGC-SD-NINYGIKFAKAFVD-ARE----------------------------------------------------RMVKDARALMNLHNNRCG-RM----AVK--RFMKTECKCHGVSGS-----CALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDG-------------TGFM-VADR--D----------------------------------------------------------------------------------YKRTTKN-D-LVY-IENSP-DYCLMDRSA-GSLG----TSGRVCNK-S------------------------------SR-GMDG-CEIMC--CGRGYDTTRVNRMT-KCEC-KFK------WCC--AVECRD-CEETVDVHTCKLHKKPDWLDLT----------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt2b.b -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFGCGEVLGSPRILVRSSAAPGGTGLRHIIRNSSGSSYGPR-------------ASSRLCCALLFL---------LLILT------------------PRVDSSWWYIG--------ALG--------------------------ARVIC--DN----I-PGLVN------K-QRQLC------QKYPDIM-Q-SIGGGAKEWIRECQYQFRHHRWNCSAL-----------------------------------DRDHTVFG--R--VI--QR--------------------------S-SREAAFVYAISSAGVVFAITRACSQ-GEL-KAC-N-C-DPQK-------------------------------R-GRASDE------------------------------------------RG-------EF-------DWGGC-SD-NINYGIKFAKAFID-AKE----------------------------------------------------RTVKDARALMNLHNNRCG-RM----AVK--RFMKLECKCHGVSGS-----CTLRTCWLAMSDFRKTGDYLRKKYNGAIEVTMNQDG-------------TGFT-VANK--D----------------------------------------------------------------------------------FRKATKN-D-LVY-FENSP-DYCLMDKTA-GSLG----TAGRVCNK-T------------------------------SR-GTDG-CEVMC--CGRGYDTTRSKRIT-KCEC-KFK------WCC--TVECKD-CEEAVDIHTCKAPKRAEWLDQT----------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN---------------------------------------------------FLPNGICFYLSVA---------ICWFS------------------SRVDASWWYMG--------TLG--------------------------SQVMC--DN----I-PGLIN------K-QRQLC------RQHPKVM-Q-AIGAGIKNWIGECQHQFRTHRWNCNTM-----------------------------------AREHNLFG--R--LL--HR--------------------------S-SREAAFVYAISSAGMVYTLTRACSQ-GEL-ENC-S-C-DPGK-------------------------------K-GSSRDA------------------------------------------KG-------AF-------DWGGC-SD-HVDHAIKFTQVFID-AKE----------------------------------------------------RKERDARALMNLHNNRAG-RK----AVK--RFMNLECKCHGVSGS-----CNVRTCWLAMADFRQTGDYLRKKYNNAIQVVMNQYG-------------TGFT-SAYR--M----------------------------------------------------------------------------------LKRPNKN-D-LVY-FEDSP-DYCIWDHES-GSVG----TGGRVCNR-T------------------------------SR-GTDS-CEVMC--CGRGYDTSRVSRTT-KCEC-KFQ------WCC--AVHCRD-CQEEVDVHTCKTQS------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR-----------------------------------------------------AEEMVVCVLLL---------ATFCI------------------STVDTSWWFLSRL--DI-NVLG--------------------------ARTIC--DN----I-PGLVP------K-QRHIC------QTHPDVM-V-SIARGAELGVRECQHQFRGDRWNCSTV-----------------------------------DRDATVFG--K--VM--DK--------------------------S-SREAAFVYAVSAAGVMFSITRSCSL-GEL-LDC-A-C-DPKK-------------------------------R-GFSEDS------------------------------------------MG-------EF-------EWGGC-SD-NVKFGEGFTRKFVD-ARD----------------------------------------------------RSQRDARAVMNMHNNRAG-RR----GVA--KNMKMECKCHGVSGS-----CTLRTCWRAMAHFRKVTDYLKRRYDGAVEVTMNQDG-------------TRLI-VSDR--N----------------------------------------------------------------------------------HKTPTKS-D-LVY-FETSP-DYCLADDDT-GSLG----TVGRQCNR-S------------------------------SL-GTDG-CDIMC--CGRGYDTTRVKRSR-KCEC-KFH------WCC--FVRCKE-CSEIIDVFTCKGPSNEFVTPN-----QRQINIPTS-RVIDQSDNIFHGSFHGPGQSKASNALAIPRISQSQHEDT------------------------------------------------------------------------------------------------ Bla_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR-----------------------------------------------------VEEMCVCVLLL---------ATFCV------------------SKVDTSWWFLSRL--DI-NVLG--------------------------ARTIC--DN----I-PGLVP------K-QRHIC------QSHPDVM-V-SIARGAELGVRECQHQFRGDRWNCSTV-----------------------------------DRDATVFG--K--VM--DK--------------------------S-SREAAFVYAVSAAGVMFSITRSCSL-GEL-LDC-A-C-DPKK-------------------------------R-GFSEDS------------------------------------------TG-------EF-------EWGGC-SD-NIKFGEGFTRKFVD-ARD----------------------------------------------------RSQRDARAAMNMHNNRAG-RR----GVA--KNMKMECKCHGVSGS-----CTLRTCWRAMSHFRKVTDYLRRRYDGAVEVTMNQGG-------------SRLT-VSDR--N----------------------------------------------------------------------------------HKTPTKS-D-LVY-FDTSP-DYCLADDDT-GSLG----TVGRQCNR-S------------------------------SL-GTDG-CDIMC--CGRGYDTTRVKRSR-KCEC-KFH------WCC--FVRCKE-CSEIIDVFTCKGPSNEFVTPN-----QRQINIPTSRRVIDQSDNIFHGSFHGSSQSKTSNVLAIPRTGQSQKEDT------------------------------------------------------------------------------------------------ Bbe_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR-----------------------------------------------------VEEVVVSALLL---------ATFCI------------------SKVDTSWWFLSRL--DI-NVLG--------------------------ARTIC--DN----I-PGLVP------K-QRHIC------QTHPDVM-V-SIARGAELGVRECQHQFRGDRWNCSTV-----------------------------------DRDATVFG--K--VM--DK--------------------------S-SREAAFVYAVSAAGVMFSITRSCSL-GEL-LDC-A-C-DPKK-------------------------------R-GFSQDS------------------------------------------TG-------EF-------EWGGC-SD-NIKFGEGFTRKFVD-ARD----------------------------------------------------RSQRDARAVMNMHNNRAG-RR----GVA--KNMKMECKCHGVSGS-----CTLRTCWRAMSHFRKVTDYLRRRYDGAVEVTMNQDG-------------TRLI-VSDK--N----------------------------------------------------------------------------------HKTPTKS-D-LVY-FETSP-DYCLADDDT-GSLG----TVGRQCNR-S------------------------------SL-GTDG-CDIMC--CGRGYDTTRVKRSR-KCEC-KFH------WCC--FVRCKE-CSEIIDVFTCKGPSKEFVTPN-----QRQINIPTS-RVIDQSD-IFDGSFHG--QSKTSNRLATPRVDQSQKGD------------------------------------------------------------------------------------------------- Sko_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-----------------------------------------------------HKIRILYFLFF---------LIFYS------------------DQVKSTWWFLSQL--SV-HAVG--------------------------TRVMC--DN----I-PGLVG------K-QRQLC------RTKPDVM-V-SIGQGAKEGVKECQFQFKNNRWNCSNL-----------------------------------DKDFSVFG--K--TM--LKT-------------------------A-SREAAFVYAISSAGVVHAITRSCSK-GEL-FDC-A-C-DLSR-------------------------------K-GKHNNK------------------------------------------HG-------EF-------DWGGC-SD-NIKFGSDFSRHFVD-ARE----------------------------------------------------RKIRDARALMNLHNNRAG-RR----AVQ--KNMKLECKCHGVSGS-----CTIKTCWLAMEEFRKVGDYLRVKYNGATEVMMNQEG-------------RELM-VANK--N----------------------------------------------------------------------------------HKRPTRL-D-LVY-FEASP-DYCVADEST-GSLG----TAGRVCNK-T------------------------------SM-GTGG-CDIMC--CGRGYDTTRAKRTT-KCEC-KFH------WCC--KVICHD-CTDIVDVHTCKSPRTDLKITH--RNTPGDGAVHLVSRDVDSLGNLNREERPVT---------------------------------------------------------------------------------------------------------------------- Lgi_Wnt2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVS--------------------------TGVLC--DN----I-PGLVG------K-QRKMC------RHYPDVM-V-WLREGARLGVEECQYQFQDHRWNCSTL-----------------------------------HRDASVFG--K--SM--LK--------------------------G-TREAAFVYSISSAGVVYSITSACSK-GEL-LHC-A-C-DPTK-------------------------------R-GTSKDS------------------------------------------KG-------EF-------DWGGC-SD-SVRFGSRFSRMFVD-AKE----------------------------------------------------KRVSDARALMNLHNNRAG-RR----AVR--RFRKLMCKCHGISGS-----CTLRTCWLAMEDFRRVGDFLKRKYNGATQIMMNQAG-------------TGLI-VANK--N----------------------------------------------------------------------------------HKHPTRS-D-LVY-FESSP-DYCIKDEES-GSLG----TEGRECIK-G------------------------------SL-GTGG-CDIMC--CGRGYDTKTIVKQE-QCEC-KFH------WCC--LVKCKE-CSKTMDVQTCKGPISSSASSL--LSSSSLSSLQTVQRVLNKP--------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt2 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VG--------------------------SGVIC--DN----I-PGLMS------R-QRLLC------RQHPDVM-M-SVVFGAKKGVKQCQRQFRHHRWNCSVS-----------------------------------HTDSSVFG--K--LM--LK--------------------------G-SKEAAFVYAISSAGVVHAITRACSQ-GRL-TNC-A-C-DPTK-------------------------------T-GSSSDR------------------------------------------NG-------KF-------DWGGC-SD-NVRYGSHFARMFVD-ARE----------------------------------------------------KRVKDARALMNLQNNRAG-RR----AVR--RHMTLECKCHGVSGA-----CTIRTCWLALQEFSRVGSYLKTRYDSAKQVSMNPMG-------------TGLI-ATTS-GG----------------------------------------------------------------------------------RKKTTRS-D-IVF-FDESP-DYCVQDPLA-GSLG----TADRECNH-T------------------------------SK-GPHG-CDVMC--CGRGYDTHVVRRMR-KCDC-KFH------WCC--YVKCRE-CEELVKVNTCRGPNPTAAPPI-----SNSIYARRTFT-------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA---------------------------------------------------PAKARLGLLVLLI---------LLYFP------------------RKTESHWWFISQV-----FALG--------------------------AKVMC--NS----I-TGLIS------I-QRQMC------LDNPDVM-V-SIGKGAKLGVEECQHQFRDQRWNCSTV-----------------------------------NGDATVFG--K--VM--RR--------------------------A-SRETAFVYAISSAGVVHEVTRSCSL-GEL-KDC-S-C-RNKK-------------------------------G----RSR------------------------------------------KG--------F-------EWGGC-SD-NIQYGLNFAKAFVD-SRE----------------------------------------------------VE-KDARALMNLHNNHVG-RR----VVK--TNMSLDCKCHGVSGS-----CSVRTCWKSISSFRIVGQHLREKYTTAVQVTVGQSG-------------GELT-NAEV--S----------------------------------------------------------------------------------YKKPSRD-D-LVY-LEDSP-NYCMVDSNT-GSLG----TSGRECNG-S------------------------------AS-DTTGACSLLC--CGRGFNTIQIEEEY-KCHC-KFH------WCC--YVKCQT-CRRTVDKHICKAPSQP----------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt2 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIGKLHSSLSSTIG--------------------------PR-IC--DQ----M-S-LKS------K-QKEIC------KTHPDVM-A-SVSEGAMKGIAECQYQFRSERWNCSTS-----------------------------------EKGQAVFG--K--VI--NR--------------------------G-SREASFVHAITAAGVMYEVTRACSR-GDI-GAC-S-C-DLHK-------------------------------R-GEGRDG------------------------------------------KG-------KF-------QWGGC-SD-DLGYSARFVSDFVD-ASE----------------------------------------------------VNVRDARASMNLHNNRAG-RK----AVK--KFMKRQCKCHGNTGA-----CPLRTCWDAMGDFRLTSDYIKVKYDNAIHVMVTQNG-------------PNES-QLIPTEK----------------------------------------------------------------------------------KKSLTRN-D-LVY-LEQSP-DYCVRDTKK-GIFG----TEGRECNL-T------------------------------SR-GSDG-CKTLC--CGRGHNTKTITRKF-KCKC-MFH------WCC--EVRCEE-CKQIIDIHTCKGETDELDIATSSGSIDSTTKIMIT------------TTKKSRRRGGKSRKRDRTRKGRKKGKKARSKRDIETGNFRNSNEVNMDDSNNAKSNLRRPERRKK--------FAGRETNRYFAKTITR----------------------------------- Hro_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MD---------HL----YNQR--------------------------------STNKLTFLFFIVF---------NQWLLQ----------------LPLVYSDWLSIGKLHSSLSSTIG--------------------------PR-IC--DQ----M-S-LKS------K-QKEIC------KTHPDVM-A-SVSEGAMKGIAECQYQFLNERWNCSTS-----------------------------------EKGQAVFG--K--VI--NR--------------------------G-SREASFVHAITAAGVMYEVTRACSR-GDI-GAC-S-C-DLHK-------------------------------R-GEGRDG------------------------------------------KG-------KF-------QWGGC-SD-DLGYSARFVSDFVD-ASE----------------------------------------------------VNVRDARASMNLHNNRAG-RK----AVK--KFMKRQCKCHGNTGA-----CPLRTCWDAMGDFRLTSDYIKVKYDNAIHVMVTQNG-------------PNES-QLIPTEK----------------------------------------------------------------------------------KKSLTRN-D-LVY-LEQSP-DYCVRDTKK-GIFG----TEGRECNL-T------------------------------SR-GSDG-CKTLC--CGRGHNTKTITRKF-KCKC-MFH------WCC--EVRCEE-CKQIIDIHTCKGETDELDIATSSGSIDSTTKIMST------------TTKKSRRRGGKGRKRDRTRKGRKKGKKARSKREIETGNFRNSNEVSMDDSNEEKSNLRRPRRRKK--------FAGRETNRNFAKTITR----------------------------------- Bsc_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHQCCK----------------------------------------------------ILNQLSLI---------LLWST-----------------ITTTHCSWAF-GRF-RGLQKAIG--------------------------PR-MC--DQ----L-S-LVP------K-QKAMC------LEDPIVM-D-SVADGAFHGIQECQHQFKNERWNCSTI-----------------------------------VKGQTVFG--K--VI--NQ--------------------------G-SREASFVHAITTAGVMHAVTRACSR-GDI-NSC-S-C-NNNK-------------------------------Y-GPGNDE------------------------------------------QG-------AF-------AWGGC-SD-DIGNGTYFIRQFVD-ASE----------------------------------------------------SDVHDARAQMNLHNNRAG-TR----AVK--RFVKRQCQCHGKTAS-----CTLRTCWESLGDFRETGDYLKERYDNAVRVTVTQNG-------------PKAT-VASA-DG----------------------------------------------------------------------------------GNQPSKN-D-LVY-LENSP-NYCNRNSVI-GTFG----TAGRECNA-T------------------------------SN-GSDG-CDKLC--CGRGYVTKKVKKIE-QHMC-EFH------WCC--EVRCKE-REQIMDVHTCNGEDEFDVAEN--PSVSSTERIPTTASATK---------AARGRRRGKKARRKKPRGRKRKNRDGKKRK----GKKRNRREVSYHVSTNIR-NTRLLSRRVD--------LKNSHHKRFGAGTRNR----------------------------------- Cro_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ME----------LPLYRYVTA--------------------------------MPHHLSLLVIVFL---------DIC--------------------TTSGNSWLFFGKL-HASSTSSI--------------------------EQ-IC--LQ----M-P-LEP------E-QKQYC------KNHTKIM-E-RIRDGTEMAMKECQYQFRNERWNCSSA-----------------------------------DE-SQGFG--K--VL--KR--------------------------G-TREAAFVGAITSAAVAHEVTRACSR-GEL-TEC-S-C-DGQK-------------------------------RMGSYRDH------------------------------------------RG-------RF-------EWAGC-SD-DVQFGMSVAKIFVN-TKD----------------------------------------------------NALHDARAIMNVHNNRAG-RK----TVK--SFMKRFCKCHGATDT-----CPLRTCWDALDSFRLSGNQLKRKYDGASRVTVKQGS-------------RKMT-LHTTVSS----------------------------------------------------------------------------------HKSPTKR-D-LVY-LEDSP-NYCVRNEAT-GSLG----TSGRECNL-S------------------------------SK-GIDG-CSLLC--CGRGHDTSSVTRTRINCAC-VFH------WCC--EVRCTN-CTNTYDIYTCKPEPMQEDPTQ--QTISSTTTDVSSAAPTRNSGTTLSTSTKGRKSGRRRNKKTRRRKGRRKGRRGRKQKN-TTGPVRAKRNIPEHEEDDVDIDVMDLNEEVEDFRLD---FDEDSLEKYRGGTWDK------NESRELYWFSKWWVTMQRFLYHDRSAVTG Csa_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ME----------L-TFQHVAK--------------------------------MPRRLALLVIVIL---------DICIS------------------SGAHSSWLFIGKL-QALSSTIE--------------------------PH-IC--EQ----I-S-LVP------A-QKNYC------DNHPKIM-V-RVRDGAQTAISECQFQFKNDRWNCSTA-----------------------------------DK-RQVFG--K--VL--QR--------------------------G-SREAAFAHAITSAAVTYEVTRACSR-GHL-IEC-S-C-DGRK-------------------------------R-GSSKDN------------------------------------------TG-------KF-------EWGGC-SD-DVQFGMSVAEEFID-ANE----------------------------------------------------IAQHDGRAIMNLHNNRAG-RK----TVK--AFKKRKCKCHGATDT-----CPLRTCWEELDEFRLTGNYLKRKYDGAVRVTVRQGS-------------REMT-LHTTVSS----------------------------------------------------------------------------------HKPPTKR-D-LVY-LEDSP-NYCIRSEAT-GSLG----TSGRECNL-T------------------------------SK-GIDG-CALLC--CGRGHDTSRVTRTR-KCNC-RFH------FCC--EIRCKL-CTETLDVYTCKPELGQEEPTR--QTVSSSSSNASSAAPTRNSGTT-GTTAKSRNRGRKRTRNRKGRKRKRKGRKGRRRKT-TTSPVRAKRGVPEYEEDDVDMDLMALNKNTDIFETDTDIFDYSDLGLHSNTVIEK-----SAQSKPVEWLVYCFDALKRLLYASINLGS- Moccu_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------------------------------------------------------------FRFLAKI-----KEIG--------------------------PH-VC--EE----L-K-SGS------R-QKAIC------KEAPKMM-R-SVSDGAVRGILECQMQFKNDMWNCS-V-----------------------------------ERGRSVFG--K--LL--NA--------------------------G-TREVAFINAITSAGVMYSITKACSR-GEY-LNC-S-C-DDKY-------------------------------S-GHGKDS------------------------------------------NG-------TF-------RWGGC-SE-DIQYGNYFAENFID-TSE-----------------------------------------------------TG-DPRSHMNLHNNIVG-RK----TLK--KFMRRRCKCHGPTGS-----CELRTCWNELGEFRLTGNHLKKRYESAVKVEVGQNN-------------GEMQ-PTKH--V----------------------------------------------------------------------------------DKDLSKN-D-LVY-LDKSP-SFCFYNHET-GSFG----TAGRRCND-S------------------------------ST-GQDS-CHVMC--CGRKFDTKVVVRKE-KCHC-RFH------WCC--NVFCDE-CERTETISTCQEDGYEVISNK---------------VPSK---------AKTKNRKGKKKKRKKGKGGKRKKS-------------RIRRHL----------------------------LVDEKVNWGQSLPDGR----------------------------------- Mocul_Wnt2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FRFLAKI-----KDIG--------------------------PH-VC--EE----L-E-PGS------R-QKAIC------KEAPKMM-R-SVSDGAVRGILECQLQFKNDMWNCS-V-----------------------------------ERGRSVFG--K--LL--NA--------------------------G-TREVAFVNAITSAGVMYSVTKACSR-GEY-LNC-S-C-DDKY-------------------------------S-GQGKDS------------------------------------------NG-------TF-------RWGGC-SE-DIQYGTYFAENFID-TSE-----------------------------------------------------TG-DPRSQMNLHNNMVG-RK----TLK--KFMRRRCKCHGPTGS-----CELRTCWNELGEFALTGNHLKKRYESAVKVEVGQNN-------------GGMQ-PIKH-------------------------------------------------------------------------------------GKVLSKN-D-LVY-LDKSP-SFCFYNHET-GSFG----TAGRRCNA-S------------------------------ST-GPDS-CHVMC--CGRKFDTKVVVRKE-KCNC-RFH------WCC--NVFCDE-CERRETISTCQEDGYDVISNK---------------VPSK---------AKTKTRKGKKKKRKKGKGGKRKKS-------------RIRRNL----------------------------LVDEKVNRGHSLPDGR----------------------------------- Mocci_Wnt2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------------------------------------------------------------------------------------------FRFLAKI-----KRMG--------------------------PY-VC--EQ----M-P-IGS------M-QREIC------TQHPKMM-K-SVGDGAGQGIIECQHQFRNEMWNCS-I-----------------------------------AKGKSVFG--K--FM--NI--------------------------G-SREVAFINAMTSASVMYAVIKACSR-GDF-PDC-A-C-DPQP-------------------------------S-GVGTDR------------------------------------------LGKFYLNICQF-------EWGGC-ND-DIKFGRSFVEKFVD-SSE----------------------------------------------------SNGRDPRSKMNLHNNMAG-RK----ALE--RFTFRDCQCHGVTGS-----CAIRTCWNEIGKIRSAGDYLKKKYQSAYKVKIRQED-------------GGLQ-PETD-LI----------------------------------------------------------------------------------SSSSLKK-E-LVY-LDESP-SFCNNSPTA-GVLG----TIGRRCNV-T------------------------------SS-GSDS-CDNMC--CGRGYVKTTVERVE-KCRC-KFK------WCC--DVICKK-CNYTEIIHTCKDDRVVDVPEK-----------PVVIVPTK----------RKRKRKDKRKKKIKNKKRKKKPK-------------RSRREVNEQFDDEID-------------------FEDENTDFILSKTFNEGFNFKKKDKR------------------------- Bfl_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDSVRC-------------------QVSVL-LLFVIWSQTADVGMGSP---------GWWY--------------------------LAVGPQFS----SLAASNAGG----------------QGRRWPVVC--SS----I-PGLVP------R-QIRYC------RKFHEIM-P-FVADGTKLGIRECQHQFRGRRWNCTTVQ-----------------------------------GQVSIFG--P--VL--DRGNISTTPKTLPRPRAGDSILGPAVNRA-SREAAFVHAITSAGVAYSVTKACAE-GTS-PDC-G-C-DN-------------------------------RHK-G-P-------------------------------------------PGEG--------W-------RWGGC-SE-DVLFGTKFSRDFVD-ARI----------------------------------------------------RGRRDGRSAMDRHNNEAG-RQ----SIM--KNLQLKCKCHGLSGS-----CEIKTCWWAQPDFRTVGNVLKDKYDSASEMAVERHR---------KPSGMVDS-LYPRYSF----------------------------------------------------------------------------------FKAPGKD-D-LIY-FEVSP-NFCEPNNST-GSLG----TKGRECNI-T------------------------------SQ-GIDG-CQLMC--CGRGWntRTEMRTE-KCHC-QFH------WCC--YVTCQE-CQKKHQVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDSVRC-------------------QVSVL-LLFVIWSQTADVGMGSP---------GWWY--------------------------LAVGPQFS----SLAAANAGG----------------QGRRWPLVC--SS----I-PGLVP------R-QIRYC------RKFHEIM-P-FVADGTKLGIRECQHQFRGRRWNCTTVQ-----------------------------------GQVSIFG--P--VL--DRGNISTTPKT-P-PRAGDSILGPAVNRA-SREAAFVHAITSAGVAYSVTKACAE-GTS-PDC-G-C-DN-------------------------------RHK-G-P-------------------------------------------PGEG--------W-------KWGGC-SE-DVFFGTKFSRDFVD-ARI----------------------------------------------------RGRRDGRSAMDRHNNEAG-RQ----SIM--KNLQLKCKCHGLSGS-----CEIKTCWWAQPDFRTVGNVLKDKYDSASEMAVERHR---------EPSGMVDS-LYPRYSF----------------------------------------------------------------------------------FKAPGKD-D-LIY-FENSP-NFCEPNNST-GSLG----TKGRECNI-T------------------------------SH-GIDG-CQLMC--CGRGWntRTEMRTE-KCHC-QFH------WCC--YVTCQE-CQKKHQVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDTVRC-------------------QVSVL-LLFVIWSQTADVSVGSP---------GWWY--------------------------LAVGPQFS----SLAASNAGG----------------QGRRWPLVC--SS----I-PGLVP------R-QIRYC------RKFHEIM-P-FVADGTKLGIRECQHQFRGRRWNCTTVQ-----------------------------------GQVSIFG--P--VL--DRGNTSSTPKT-P-PRAGDSILGPAVNRA-SREAAFVHAITSAGVAYSVTKACAE-GTS-PDC-G-C-DN-------------------------------RHK-G-P-------------------------------------------PGEG--------W-------KWGGC-SE-DVLFGTKFSRDFVD-ARI----------------------------------------------------RGRRDGRSAMDRHNNEAG-RQ----SIM--KNLQLKCKCHGLSGS-----CEIKTCWWAQPDFRTVGNVLKDKYDSASEMAVERHR---------EPSGMVDS-LYPRYSF----------------------------------------------------------------------------------FKAPGKD-D-LIY-FENSP-NFCEPNNST-GSLG----TKGRECNI-T------------------------------SH-GIDG-CQLMC--CGRGWntRTELRTE-KCHC-QFH------WCC--YVTCQE-CQKKHQVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------------DLYLVGFLMCMWFSSSRVLGGYP---------IWWS--------------------------LALGQQYS----SIGSQ-------------------------PILC--GS----I-PGLVP------K-QLRFC------RNYIEIM-P-SVAEGVKLGIQECQHQFRGRRWNCTTIK-----------------------------------DSLAIFG--P--VL--D--------------------------KA-TRESAFVHAIASAGVAFAVTRSCAE-GTS-TMC-G-C-DS-------------------------------HHK-G-P-------------------------------------------PGEG--------W-------KWGGC-SE-DAEFGVLVSREFAD-ARE-----------------------------------------------------NRPDARSAMNRHNNEAG-RM----TIL--ENMHLRCKCHGLSGS-----CEVKTCWWAQPDFRLLGDYLKDKYDSASEMVVEKHR---------ESRGWVET-LRAKYAF----------------------------------------------------------------------------------FKHPTER-D-LVY-YEGSP-NFCEPNPET-GSFG----TRDRACNV-S------------------------------SH-GIEG-CDLLC--CGRGHNTRTEKRKE-KCHC-IFH------WCC--YVSCQE-CVRVYDVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------------EPHLLGLLLGLLLGGTRVLAGYP---------IWWS--------------------------LALGQQYT----SLGSQ-------------------------PLLC--GS----I-PGLVP------K-QLRFC------RNYIEIM-P-SVAEGVKLGIQECQHQFRGRRWNCTTID-----------------------------------DSLAIFG--P--VL--D--------------------------KA-TRESAFVHAIASAGVAFAVTRSCAE-GTS-TIC-G-C-DS-------------------------------HHK-G-P-------------------------------------------PGEG--------W-------KWGGC-SE-DADFGVLVSREFAD-ARE-----------------------------------------------------NRPDARSAMNKHNNEAG-RT----TIL--DHMHLKCKCHGLSGS-----CEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHR---------ESRGWVET-LRAKYSL----------------------------------------------------------------------------------FKPPTER-D-LVY-YENSP-NFCEPNPET-GSFG----TRDRTCNV-T------------------------------SH-GIDG-CDLLC--CGRGHNTRTEKRKE-KCHC-IFH------WCC--YVSCQE-CIRIYDVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt3a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------------------IYLGYFLFLFCGLTRVMASYP---------IWWS--------------------------LAVGHQYT----SLGTQ-------------------------PIMC--SS----I-PGLVP------K-QLRFC------RNYVEIM-P-SVAEGVKIGIQECQHQFRGRRWNCTTIN-----------------------------------DKLAIFG--P--VL--D--------------KEKERKIGFKQAKA-TRESAFVHAIASAGVAF-VTRACTE-GSA-TIC-G-C-DS-------------------------------RRK-G-P-------------------------------------------PGEG--------W-------KWGGC-SE-DVEFGSMVSREFAD-ARE-----------------------------------------------------NRPDARSAMNRHNNEAG-RS----SIT--DHMYLKCKCHGLSGS-----CEVKTCWWSQPDFRVIGDYMKDKYDSASEMVVEKHR---------ESRGWVET-LRPKYPY----------------------------------------------------------------------------------YKPPTET-D-LVY-YESSP-NFCEPNPET-GSFG----TRDRTCNL-T------------------------------SH-GIDG-CDLLC--CGRGHNTRTEKRKE-KCHC-IFH------WCC--YVSCQE-CTRVYDVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT3a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------------------APLGYFL-LLCSLKQALGSYP---------IWWS--------------------------LAVGPQYS----SLGSQ-------------------------PILC--AS----I-PGLVP------K-QLRFC------RNYVEIM-P-SVAEGIKIGIQECQHQFRGRRWNCTTVH-----------------------------------DSLAIFG--P--VL--D--------------------------KA-TRESAFVHAIASAGVAFAVTRSCAE-GTA-AIC-G-C-SS-------------------------------RHQ-G-S-------------------------------------------PGKG--------W-------KWGGC-SE-DIEFGGMVSREFAD-ARE-----------------------------------------------------NRPDARSAMNRHNNEAG-RQ----AIA--SHMHLKCKCHGLSGS-----CEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHR---------ESRGWVET-LRPRYTY----------------------------------------------------------------------------------FKVPTER-D-LVY-YEASP-NFCEPNPET-GSFG----TRDRTCNV-S------------------------------SH-GIDG-CDLLC--CGRGHNARAERRRE-KCRC-VFH------WCC--YVSCQE-CTRVYDVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------IW--------------CCLFLCFLLWFQVTAVP---------MWWA--------------------------LGVS--YS----PASVE-------------------------EISC--GQ----I-PGLVS------K-QLRFC------RRNQELM-P-SVAEGAQLGIRECQNQFKGRRWNCTTVG-----------------------------------NDQSVFG--N--VL--N--------------------------NA-SRETAFVHAILSAGLVHTVTRACAS-GEL-LSC-G-C-DS-------------------------------KRK-P-P-------------------------------------------PEEG--------W-------KWGGC-SE-DIRYGTRFSRDFLD-PQE-----------------------------------------------------NPRYARSVMNLHNNEAG-RQ----TIA--KTMETQCKCHGLSGS-----CEVKTCWKQQSAFKILGDLLKEKYDSAPEMKVTRHK---------EMRGWQEE-LIPKYDH----------------------------------------------------------------------------------FKQPTSA-D-LIY-YEPSP-NFCKHDPSI-GSFG----TEGRRCNA-T------------------------------SN-GIEG-CDLMC--CGRGYNTIPEEVVE-RCEC-QFI------WCC--KVKCKS-CRRMYDLHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTLLSAGRERRHIVHKL--------ALMLL-LLQCVPLLVDGVRYGAP---------RWWNVI----------------------NLLPTREQNSTNILSATKI-------------------------AIPC--PK----I-PGLVP------A-QLRYC------QSHNELM-Q-SVSEGTRIGIEECKYQFQERRWNCSTILL-----------------------KSKK-A----FKKKSIFG--A--VL--N--------------------------IA-SRETAFAYAIASAGLSHRVTKECSK-GVL-SLC-G-C-DT-------------------------------KMQ-G-S-------------------------------------------DTEN--------W-------RWGGC-ND-DVKFGVDVSRQFAD-AHE-----------------------------------------------------YDTTARPSMNRYNNEAG-RQ----ILI--NNMKLRQKCHGLSGS-----CELKTSWWSLPSFREVGNTLKEKYDQATEMKIQKHR---------EASGIVET-LVPKFKK----------------------------------------------------------------------------------FRKPGRE-D-LIY-YQRSP-DYCQSNDKL-NILG----THGRICNV-T------------------------------SD-GIDG-CDLLC--CARGYTTETLTKTV-RCNC-VFH------WCC--HVTCQQ-CQVQYQVTRCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTLLSAGRERRHIVHNW--------ILLLL-LLQCVPLLVDGVRYGAP---------RWWNVI----------------------NLLPTREQNSTNILSATKI-------------------------AIPC--PK----I-PGLVP------A-QLRYC------QSHNELM-Q-SVSEGTRIGIEECKYQFQQRRWNCSTIRL-----------------------KGKK-A----FRKKSIFG--A--VL--N--------------------------IA-SRETAFAYAIASAGLSHRVTKECSK-GVL-SLC-G-C-DT-------------------------------KMQ-G-S-------------------------------------------DTEN--------W-------RWGGC-ND-DVKFGVDVSRQFAD-AHE-----------------------------------------------------YDTTARPSMNRYNNEAG-RQ----ILI--NNMKLRQKCHGLSGS-----CELKTSWWSLPSFREVGNTLKEKYDQATEMKIQKHR---------EASGIVET-LVPKFKK----------------------------------------------------------------------------------FRKPGRE-D-LIY-YQRSP-DYCRSNDKL-NILG----THGRICNV-T------------------------------SD-GIDG-CDLLC--CARAYTTETLTKTV-RCNC-VFH------WCC--HVTCQQ-CQVQYQVTRCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKKSSA-------VTSWLKRIFILCLQVML-TLQVLSPIMCVEGTGAP---------RWWNII----------------------RLLQLHPSNSTHYPSYVAE-------------------------PIIC--TQ----V-PGLGT------R-QLRFC------SSNTDLM-P-SIAHGTKMGIDQCKHQFSDRRWNCPTQPL-----------------------RTAR-P----IRRRNVFG--P--VL--E--------------------------RA-SKEAAFVHAINSAGVAHSITKACSS-GDM-RSC-G-C-DDR------------------------V-----KEK-T-PALQEI--------------------------------------VGGK--------W-------SWSGC-SD-DVQYGVAASRQFVD-APD-----------------------------------------------------QGRDARAIMNRHNNEAG-RQ----VLL--RKMQIKCKCHGVSGS-----CQFRTCLWALPHFNNVGSELKQMYVKAKNMRVERHL---------ETRGIAES-LVPGPTT----------------------------------------------------------------------------------LRPPTTN-D-LVY-YQESH-DYCERDDSL-GIQG----TSGRLCNA-T------------------------------SD-GVDN-CNLLC--CGRGYTTAHKTRVE-KCRC-RFQ------WCC--TVTCEE-CIVHYEEHTCI---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------CYVF--------LQAML-ISSVISPISIVDGTGAP---------RWWNII----------------------RLLQFHPRNATHYPSYTTS-------------------------PIIC--TR----L-PWLGA------R-QLQFC------SNNIELM-P-SIAHGTKMGIDQCKHQFNNRRWNCKTQPV-----------------------QHPR-A----SRRGNVFG--P--VL--E--------------------------RA-SREAAFVHAIAAAGVAYSVTKACST-GTL-RSC-G-C-DNR------------------------V-----KGK-K-S-------------------------------------------IGVK--------W-------SWGEC-ND-NVQVGVAASRKFAD-ATD-----------------------------------------------------QGSDARSIMNRHNNEAG-RQ----VLL--RGMRFICKCHGVSGS-----CQFQTCFWSLPRFSSVGAELKRMFIDAQKMRVERHL---------ETRGWVES-LVRGAET----------------------------------------------------------------------------------VRSPTTN-D-LVY-YEESP-DFCERNVSL-GIEG----TRGRLCNA-T------------------------------SS-GVDN-CDLLC--CGRGYTTTPRTRVE-RCRC-TFQ------WCC--KVTCDQ-CTVHYEEHRCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt3 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVDMA-------------------------TMAC--SR----I-PGLNS------R-QLRFC------TMNRSFM-P-SIADGTQLGFKQCQLQFKNRRWNCSTVSR---G-------------------ITRH-G----NRRRSLFG--S--VL--E--------------------------KG-SKEAAFVHALAAAGVAHSITKSCWK-GNL-ENC-K-C-NN-------------------------IGRLRPRFR-S-L-------------------------------------------PRVD--------W-------KWGSC-DE-NVEYGIVRSRDFVD-ARD-----------------------------------------------------HSTYARSIMNLHNNEAG-RE----ALR--DQVRRKCKCHGVSGS-----CELKTCWLVLPDFNHVGSYLKQRYLDASLMKVQSFT---------GARGCEDD-FVPSHPF----------------------------------------------------------------------------------HRRPTKK-D-LIY-YESSP-DFCERNDAL-GIKG----TRGRICNA-D------------------------------SD-GVDG-CFLLC--CGRGYTTKRKTRVE-KCRC-VFQ------WCC--KVKCED-CVIEYEEHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLVGS-------VAVW------IYPMFWF-VIFRMVTSKCEARNGAP---------KWCT--------------------------------------SVDMA-------------------------TMAC--SR----I-PGLNS------R-QLRFC------TMNRSFM-P-SIADGTQLGFKQCQLQFKNRRWNCSTSSR---S-------------------VSGH-G----SRRRNLFG--S--VL--E--------------------------RG-N---------AAAGVAHSITKSCWK-GNL-ENC-K-C-NN-------------------------IGRLRPRFR-S-L-------------------------------------------PRID--------W-------KWGSC-DE-NVEYGIARSRDFVD-ARD-----------------------------------------------------QSPYARSIMNLHNNEAG-RE----ALR--DQVRRKCKCHGVSGS-----CELKTCWLVLPDFNQVGAYLKQRYLDASLMKVQSFT---------GVRGCEDD-FVPSHSF----------------------------------------------------------------------------------HRRPTKK-D-LIY-YESSP-DFCDRNVAS-GIKG----TRGRICNA-D------------------------------SE-GVDG-CFLLC--CGRGHTTKRKTRVE-KCRC-VFQ------WCC--KVKCED-CVIEYEEHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRV----------------------------IITAIVPLISLLVSSEA---------VWWTLG----------------------TQLSVSS-------DPAKK-------------------------SMLC--YV----T-RQFNS------R-QQEVC------RKNPDLM-E-HVAHGAKYGVHECRHQFRNRRWNCSTIR-----------------------------------ESGSLFE--S--VL--S--------------------------KG-CREAAFVHAVTAAGVAHSVTDACSK-GRI-ESC-D-C-DR-------------------------------NLS-G-R-------------------------------------------SSKG--------W-------TWSGC-NS-NIKFGVWFSKQFTE-ARE-----------------------------------------------------RGGDLRQIMNRHNSRAG-RK----ALE--ELVWRKCKCHGLSGS-----CSMKTCWMQQANFRQIGDHLKVKYDSAVEMTTKVNR---------RGK---KR-LKPKYSH----------------------------------------------------------------------------------FKKPSDK-D-LIY-FETSP-NYCDKNVTV-GSLG----TSGRQCNY-T------------------------------SN-GIDG-CELLC--CGRGHNIQQAKITR-NCNC-VFK------WCC--EVKCER-CKEVVNIYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSRRRKGQA---LHFW--------------IFFILGCGTVIGRTGSP---------RWWNII----------------------QQLSITPMNGTLTISTKGK-------------------------PFSC--SR----I-PGLVP------Q-QIRFC------KKYKDLM-L-PIAYGTHLGLEQCKEQFKGRRWNCSTMVDGGNT-------------------RATK-A----LRRKGILG--G--VL--E--------------------------TG-ARETAFVHAIAAAGLVYSIAKFCNSAGTSFQYC-G-C-DDSAR---------------------DFNAELLNNH-K-F-------------------------------------------RAVK--------W-------RWGSC-NE-NTHFGAFVANNFAG-AGE-----------------------------------------------------RGRSARVLMNTHNNKAG-IK----AVR--SNVIIKCKCHGLSGS-----CELETCWWAMKNFKEIGSKLKDKYDGASEMKII------------TSRGVAHK-LIPVLQS----------------------------------------------------------------------------------ATPPKED-D-LVY-YEKPP-DFCERNTTL-GIFG----TTGRVCNA-T------------------------------ST-GIDG-CDLLC--CGRGYHTRSRSKTV-KCQC-VFH------WCC--TVTCKS-CVVKYKENICL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSRRTKGQALYSLHFW--------------IFFILSCGTAIGRTGSP---------RWWNII----------------------QQLSITPMNGTLTISTKGK-------------------------PFSC--SR----I-PGLVP------Q-QIRFC------KKYKDLM-L-PIAYGTHLGLEQCKEQFKGRRWNCSTMVDGGNT-------------------RATK-A----LRRKGILG--G--VL--E--------------------------TG-SRETAFVHAIAAAGLVYSVAKFCNSAGNSFQYC-G-C-DDSAR---------------------DFNAELLKNH-K-F-------------------------------------------RAVK--------W-------RWGSC-NE-NTHFGAFVANNFAG-AGE-----------------------------------------------------RGRSARVLMNTHNNKAG-IK----AIR--SNVIIKCKCHGLSGS-----CELETCWWAMKNFKEIGSKLKDKYDGASEMKII------------TSRGVAHK-LIPVFQS----------------------------------------------------------------------------------VTPPKED-D-LVY-YEQPP-DFCERNTTV-GIFG----TIGRVCNA-T------------------------------ST-GIDG-CDLLC--CGRGYHTRSRSKTV-KCQC-VFH------WCC--TVTCKS-CVVKYKENICL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRPSRV-GPG---FHYS--------LLAVGVVTYLFVIGSDCAKPGSP---------RWWNII----------------------KQLRIQPINRTLTITTQGR-------------------------SLAC--SR----I-PGLVP------Q-QLRFC------KKYKELM-V-PIAYGTYVGLEECKRQFKGRRWNCSTIESSSDP-------------------KTNR-A----LRRKGLFS--G--VM--E--------------------------AA-SRESAFVHAIAAAGLVYSVTKYCSD-GRS-RFC-G-C-DTDRS---------------------AFEATWLRHK-V-V-------------------------------------------NNKN--------W-------RWSGC-ND-NVGFGVWAAIKFAD-ANE-----------------------------------------------------RKKTARALMNSHNNRAG-RK----AVT--DNMIIKCKCHGLTGS-----CEMQTCWRAMKSFKEIGEIIKDKYDGASQMKKE------------ESDGVAHR-LIPISDS----------------------------------------------------------------------------------DTPPKED-D-LIY-YEKPP-NFCDRNEDL-GIYG----TTGRVCNA-T------------------------------SS-GIDG-CDLLC--CDRGFVKLSKTKTV-RCRC-VFH------WCC--TVTCDK-CAVNYEEH------------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT5a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--KKSIGILSPGVALGMAGSAMS-SKFFLVALAIF-FSFAQVVIEAN---------SWWSLGMNNP-----------------VQMSEVYIIGAQP----------------------------------LC--SQ----L-AGLSQ------G-QKKLC------HLYQDHM-Q-YIGEGAKTGIKECQYQFRHRRWNCST-------------------------------V----D-NTSVFG--R--VM--Q--------------------------IG-SRETAFTYAVSAAGVVNAMSRACRE-GELST-C-G-C-SRAA-----------------------------RPK-DLP---------------------------------------------RD--------W-------LWGGC-GD-NIDYGYRFAKEFVD-ARERERIHA------------------------------------------K---GSYESARILMNLHNNEAG-RR----TVY--NLADVACKCHGVSGS-----CSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGK--------LV-----Q-VNSRF-------------------------------------------------------------------------------------NSPTTQ-D-LVY-IDPSP-DYCVRNEST-GSLG----TQGRLCNK-T------------------------------SE-GMDG-CELMC--CGRGYDQFKTVQTE-RCHC-KFH------WCC--YVKCKK-CTEIVDQFVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT5b -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP-SLLLLFTAALL-SSWAQLLTDAN---------SWWSLAL-NP-----------------VQRPEMFIIGAQP----------------------------------VC--SQ----L-PGLSP------G-QRKLC------QLYQEHM-A-YIGEGAKTGIKECQHQFRQRRWNCST-------------------------------A----D-NASVFG--R--VM--Q--------------------------IG-SRETAFTHAVSAAGVVNAISRACRE-GELST-C-G-C-SRTA-----------------------------RPK-DLP---------------------------------------------RD--------W-------LWGGC-GD-NVEYGYRFAKEFVD-AREREKNFA------------------------------------------K---GSEEQGRVLMNLQNNEAG-RR----AVY--KMADVACKCHGVSGS-----CSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRVTRKGR--------LE-----L-VNSRF-------------------------------------------------------------------------------------TQPTPE-D-LVY-VDPSP-DYCLRNEST-GSLG----TQGRLCNK-T------------------------------SE-GMDG-CELMC--CGRGYNQFKSVQVE-RCHC-KFH------WCC--FVRCKK-CTEIVDQYICK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt5b -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVRMN-QGHLLLAVTLI-VCNSQLLVVAN---------SWWSLAM-NP-----------------IQRPEMYIIGAQP----------------------------------LC--SQ----L-TGLSQ------G-QRKLC------QLYQDHM-V-YIGEGAKTGIKECQYQFRQRRWNCST-------------------------------V----D-NTSVFG--R--VM--H--------------------------IG-SRETAFTYAVSAAGVVNAVSRACRE-GELST-C-G-C-SRAA-----------------------------RPR-DLP---------------------------------------------RD--------W-------LWGGC-GD-NVNYGYRFAREFVD-AREREKNYP------------------------------------------R---GSVEHARTLMNLQNNEAG-RM----AVY--NLANVACKCHGVSGS-----CSLKTCWLQLADFRRVGEFLKEKYDSAAAMRINRRGK--------LE-----L-VNNRF-------------------------------------------------------------------------------------NPPTGE-D-LVY-IDPSP-DYCLRNETT-GSLG----TQGRLCNK-T------------------------------SE-GMDG-CELMC--CGRGYDQFKTYKHE-RCHC-KFH------WCC--YVKCKR-CTSLVDQFVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt5a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MM-----LLKLKWTSSGVKD--TP-HTLLSIIITFC-VFFMLEIVDAN---------SWWSLAM-NP-----------------LLIPEVYVIGGQP----------------------------------LC--SQ----L-SGLSK------G-QKKLC------QLYQDHM-Q-YIGEGAKTGIRECQHQFRHRRWNCST-------------------------------V----D-NSTVLG--R--VM--H--------------------------IG-SRESAFAFAISAAGVLHAVSRACRE-GALSS-C-G-C-SRAS-----------------------------RPK-DLP---------------------------------------------RD--------W-------LWGGC-GD-NLNYGYRFSREFVD-AREREKTFS------------------------------------------K---GSAESARQMMNLHNNEAG-RR----IVS--DLADVSCKCHGVSGS-----CSLKTCWLQLADFRKVGDVLKEKYDSAAAMRMNGRGK--------LV-----Q-MHSKF-------------------------------------------------------------------------------------SPPSGQ-D-LLY-LQPSP-DYCIRNSSS-GSLG----TQGRLCNK-T------------------------------SE-GMDG-CALMC--CGRGYDQYKAELVE-RCHC-KFH------WCC--YVRCKR-CSSIVDQYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYRMARYIELFFLI-FTSVQSLSQGQ---------SWWLLGL-KSHV------------FQTWSKVGIIGPSIQS----------------------------------LC--NQ----L-EGLSQ------G-QTKLC------HLYQDHM-Y-PISTGAKSGIEECQYQFSERRWNCST-------------------------------V----D-GQSVFG--N--VM--T--------------------------IA-SREKAFTYAISAAGVVNAISRACRE-GELAN-C-G-C-SRAL-----------------------------RPT-DLN---------------------------------------------RD--------W-------LWGGC-GD-NVDYGYRFTKEFVD-MKENERIPP------------------------------------------K---ASAEHGIMKMNLHNNEAG-RK----AVL--SMADVMCKCHGVSGS-----CSMKTCWLQLANFRDVGNELKERYDGAAEIRRNRRGE--------IK-----L-VDSRF-------------------------------------------------------------------------------------NNPTAF-D-LVY-LDPSP-DYCIYDPST-GSLG----TVGRLCNK-T------------------------------SM-GMDG-CNLMC--CGRGYNTFQQEVVE-RCHC-KFH------WCC--YVKCKR-CKKIVDMHICK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVQVS-LRVLR--VLVTLL-SCYTHLGRVRA---------TWWQMAV-DSR-------------LYSLSRAELYIIGAQP----------------------------------LC--TT----L-AGLSS------G-QRKLC------NLYQDHM-S-SVGIGARQGIEECQHQFRDRRWNCTT-------------------------------S----D-EDSVFG--R--IV--N--------------------------IG-SREASFTYAIAAAGVVNAVSRACRE-GELTT-C-G-C-SRAK-----------------------------RPK-DLN---------------------------------------------RD--------W-------LWGGC-GD-DVEYGYYFAREFVD-AQEKEII-PT-----------------------------------------P---GSHAHARQMMNMHNNEAG-RK----LTF--NNARVACKCHGVSGS-----CSLKTCWQQLADFRTVGNLLKDKYDGANEVKLVKRGKRY-----RLD-----R-RNPKF-------------------------------------------------------------------------------------NVFTDE-D-LVY-LNRSP-DYCNADPTI-GSLG----THGRECNK-T------------------------------GL-GTDG-CNLMC--CGRGYNTFKREKVE-RCNC-KFH------WCC--YVKCKR-CRSIEDVYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVQVS-LRVLR--VLVTLL-SCYTHLGRVRA---------TWWQMAV-DSR-------------LYSLSRAELYIIGAQP----------------------------------LC--TT----L-AGLSS------G-QRKLC------NLYQDHM-S-SVGIGARQGIEECQHQFRDRRWNCTT-------------------------------S----D-EDSVFG--R--IV--N--------------------------IG-SREASFTYAIAAAGVVNAVSRACRE-GELTT-C-G-C-SRAK-----------------------------RPK-DLN---------------------------------------------RD--------W-------LWGGC-GD-DVEYGYYFAREFVD-AQEKQII-PT-----------------------------------------P---GSQAHARQLMNMHNNEAG-RK----LTF--SNARVACKCHGVSGS-----CSLKTCWQQLADFRTVGNLLKDKYDGANEVKLIKRGKRY-----RLD-----R-RNPRF-------------------------------------------------------------------------------------NVFTDE-D-LVY-LNKSP-DYCNADPTI-GSLG----THGRECNK-T------------------------------GL-GTDG-CNLMC--CGRGYNTFKREKVE-RCNC-KFH------WCC--YVKCKR-CRSIKNVYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVQMS-LRVLR--VLVTLL-SCYTHLGRVRA---------TWWQMAV-DSR-------------LYSLSRAELYIIGAQP----------------------------------LC--TS----L-AGLSS------G-QRKLC------NLYQDHM-A-SVGIGARQGIEECQHQFRDRRWNCTT-------------------------------S----D-EDSVFG--R--IV--N--------------------------IG-SREASFTYAIAAAGVVNAVSRACRE-GELTT-C-G-C-SRAK-----------------------------RPK-DLN---------------------------------------------RD--------W-------LWGGC-GD-DVEYGYYFAREFVD-AQEKEII-PS-----------------------------------------P---GSSAHARQLMNMHNNEAG-RK----LTF--SNARVACKCHGVSGS-----CSLKTCWQQLADFRTVGNLLKDKYDGANEVKLIRRGKRY-----RLD-----R-RNPRF-------------------------------------------------------------------------------------NVFTDE-D-LVY-LNKSP-DYCNADPTI-GSLG----THGRECNK-T------------------------------GL-GTDG-CNLMC--CGRGYNTFKREKVE-RCNC-KFH------WCC--YVKCKR-CRSIEDVYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHI----RH-K-----LLL--C--LAAIVHS---------SEWTSLP-D-R------------------N--WLKKN--------------------------------------C--KS----R-H-LTK------I-QERIC------QSKLDHM-D-YVNMASKNALQECQSQFHNAAWNCTDFQ-----------------------------K----SRKDTIYG--R--HA--K--------------------------AG-TKETAFITAITSAALVRELAMGCRR--NL-AAC-K-CGSNTN--------------------------VNPQPS-RLP---------------------------------------------PG--------T-------EWDRC-GD-NIAYAKTFAEEFVDIA-EMEARQESERCLRAVNENDPKADDYCHFFKKRGQINKE-----------K---IHYRIAKLKMNLHNSDAG-RN----TVE--RTKKVTCKCHGMSGS-----CNQKTCWHDVADIKTIGNFLKEKYDFSQKIKLSVK-KRHTDG-GHILEQVELK-DPNTREKR----------------------------------------------------------------------------------KVPPDD-D-LWW-IQKSP-NFCKPDRKK-NILG----TSERECDP-T------------------------------SD-GEDS-CKKMC--CGRGYFKEQFKVKE-ECNC-EFK------WCC--QIECEV-CEVTKKIYKCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-----CRIPW--IYILLIASLKALSITARD---------MWWNLGV-NG--------------FDLWKNPELYLLGVSP----------------------------------VC--NQ----L-KGLSP------G-QTKFC------QLYQDHM-P-AVSAGAKIALGECQQQFHSRRWNCSL-------------------------------M----EGNGAVFG--P--VL--D--------------------------TG-SRESAFTYAIFAAGVVHAVSRSCRD-GQLTN-C-G-C-SRRM-----------------------------RPK-TLH---------------------------------------------RD--------W-------LWGGC-GD-NTDYGYRFAQGFVD-IREREKNHP------------------------------------------R---HSPELARTLMNLHNNEAG-RR----AVY--SHTVVACKCHGVSGS-----CSLKTCWNQLAPFRGTGNRIKDAYDRGTEVAFNRQGT-------RLV-----Q-TNKRF-------------------------------------------------------------------------------------NKPTKE-D-LLY-LAESP-DYCEADPGI-GSLG----TQGRQCNK-H------------------------------SQ-GMDG-CNLMC--CGRGYNTYKAKVSE-RCQC-NFH------WCC--YVQCKT-CERVVDINTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA--GLERR--W--SVILLIA-LQALLVSTLD---------MWWNLGV-HH--------------FDTIRKNNLYMLAAQP----------------------------------MC--TE----L-QGLSP------G-QIRFC------RVYHDHM-P-SIGRGAQLGIHECQYQFRNRRWNCST-------------------------------V----D-DSSVFG--P--VL--N--------------------------IG-NREAGFTHSISAAGVVYAISRACRE-GELSK-C-G-C-SRAR-----------------------------RPK-DLH---------------------------------------------RD--------W-------IWGGC-GD-NIEYGYKFAKAFVD-MREKEKNHP------------------------------------------R---HSRDLSRMLMNVHNNEAG-RR----AVY--NFAKVACKCHGVSGS-----CSLKTCWQHLPNFREIGNRLKDRYDASTEVKFNKRGT-------KLT-----R-KVKKW-------------------------------------------------------------------------------------NKYTKN-D-IIF-LDDSP-DYCDKNAET-GSVG----TAGRECDR-N------------------------------SQ-GLGG-CGLLC--CGRGYNTFKRKLIE-RCNC-KFH------WCC--FVRCGS-CERYVDVHICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESNSRRTQSNS--SML-VLL-IAVLISPACS---------IWWSIAT-RP-------------------MMDAMVLGTQP----------------------------------IC--GQ----L-EGLSR------N-QRALC------QRYANHM-A-HVSEGAGIGINECKWQFRGQRWNCST-------------------------------V----D-DSSVFG--K--VL--K--------------------------IG-SKETAFTYAISAAGVVVAVARACKN-EQLEN-C-G-C-GNKA-----------------------------RPE-GLD---------------------------------------------AS--------W-------RWGGC-GD-NTEYAYGFAREFID-ARERDNISP------------------------------------------K---RRKDRERKVMNMHNNEAG-RM----VVV--RSARPTCKCHGVSGS-----CSLKTCWMQVPGFREIGDELMRKYIGGVEVRVTNRGQ--------LR-----P-RRSND-------------------------------------------------------------------------------------EV-GST-S-LVY-LDSSP-DYCDKNRRT-GVAG----TKGRECKK-D------------------------------SS-GPEG-CGLLC--CGRGFRTYRVRVVE-KCEC-KFQ------WCC--SVKCNL-CQRTVKRHICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt5 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEHKAGRPQSSY--SMLILCL-MLQVTTPTSS---------YWWSIAT-RP-------------------MMDALVLGTRP----------------------------------IC--GQ----L-EGLSR------N-QRALC------QRYASHM-P-YVSEGAGIGINECKWQFRGQRWNCST-------------------------------V----D-DSSVFG--K--VL--K--------------------------IG-SKETAFTYAISAAGVVVAVARACKN-EQLRE-C-G-C-SNVA-----------------------------RPD-GLD---------------------------------------------PS--------W-------RWGGC-GD-NTEYAYGFAREFID-ARERDNISP------------------------------------------K---RRKDRARKAMNMHNNEAG-RM----VVV--RSATPTCKCHGVSGS-----CSLKTCWMQIPGFREIGDELMRTYTDGVEVRATSGGQ--------LR-----P-RRTNE-------------------------------------------------------------------------------------EV-TRT-S-LVF-LDSSP-DYCNRNRRT-GVAG----TKGRKCEK-H------------------------------SS-GPEG-CGLLC--CGRGSRTYSVRVVE-KCEC--FE------WCC--KVKCKK-CQRVVQRHVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt5a -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-RRKQRNQIPG--IFVTVLT-FLYCVTLAET---------HWWSLAN-GP-------------------LVDIISSGPGQ----------------------------------VC--DH----V-QGMSR------N-QKLLC------GRYHDHM-K-YVSEGARNGIDECQWQFRDHRWNCTV-------------------------------N----E-DSTVFG--K--VL--N--------------------------IG-SKETAFSYAISAAGVVHSVARACKT-QKLKA-C-G-C-STTQ-----------------------------RPP-KLH---------------------------------------------KD--------W-------EWGGC-GD-DTEYAYGFAREFID-ARERDNLAP------------------------------------------R---G-KARIRKAMNMHNNEAG-RL----NVV--RSARPTCKCHGASGS-----CSLKTCWMQVPTFRDIGDRLREEHKNAKEVRLGKRGQ--------LR-----P-RKSGR-------------------------------------------------------------------------------------IQPTIT-N-LVY-IESSP-DYCKRNSRT-GVPG----TRGRRCDE-N------------------------------SD-GMDG-CGLLC--CGRGYKSRRVEVVE-RCNC-KFQ------WCC--VVRCQK-CKKTIQRHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt5a -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-HQKQMNQIPG--IFVTVLT-FLYCVTLAET---------HWWSLAN-GP-------------------LVDIISSGPGQ----------------------------------VC--DH----V-QGMSR------N-QKLLC------GRYHDHM-K-YVSEGARNGIDECQWQFRDHRWNCTV-------------------------------N----E-DSTVFG--K--VL--N--------------------------IG-SKETAFSYAISAAGVVHSVARACKT-QKLEA-C-G-C-STTG-----------------------------RPP-KLH---------------------------------------------KD--------W-------EWGGC-GD-DTEYAYGFAREFID-ARERDNLAP------------------------------------------R---G-KARIRKAMNMHNNEAG-RL----NVV--RSARPTCKCHGASGS-----CSLKTCWMQVPTFREIGDRLRDEHKNAKEVRLGKRGQ--------LR-----P-RKSGR-------------------------------------------------------------------------------------VQPTIS-N-LVY-IESSP-DYCKRNSRT-GVPG----TRGRRCDE-N------------------------------SD-GMDG-CGLLC--CGRGYKSRRVEVLE-RCNC-KFQ------WCC--VVRCQK-CKKTIQRHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt5b2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR-ATVADTSI----------------------------------PC--SE----I-PSLSH------S-QRALC------QKYRDHI-L-LVSEGAQKGIEECQYQFRARRWNCSTTTNKKR--------------------KIDN-N----D-SNTVFG--K--VI--D--------------------------IG-SRETAFTYAISAAGVVHTIARGCKE-GRLEA-C-G-C-SNSP-----------------------------RPD-GLR---------------------------------------------DE--------W-------EWGGC-GD-NLDYAYGFAHEFID-ARERDNVSP------------------------------------------R---NPKSRSRKVMNLHNNEAG-RM----TVV--RGARPTCKCNGVSGS-----CSLNTCWLRVPHFREIGDKIREKHDSSIEIKVNKRSR--------MR-----P-RKKGI-------------------------------------------------------------------------------------EAPTIT-D-LVH-LDSSP-DYCRANSRT-GVLG----TKGRECNA-H------------------------------SD-GSDG-CGLMC--CGRGYDTRVVDVEE-RCNC-RFQ------WCC--VVRCQK-CIKRVQRFICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt5b2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR-ATVADTSI----------------------------------PC--SE----I-PSLSH------S-QRALC------QKYRDHI-L-LVSEGAQKGIEECQYQFRARRWNCSTTTNKKR--------------------KIDN-N----D-SSTVFG--K--VI--D--------------------------IG-SRETAFTYAISAAGVVHAIARGCKE-GRLEA-C-G-C-SNSP-----------------------------RPD-GLR---------------------------------------------DE--------W-------EWGGC-GD-NLDYAYGFAHEFID-ARERDNVSP------------------------------------------R---NLKSRSRKVMNLHNNEAG-RM----TVV--RGARPTCKCNGVSGS-----CSLNTCWLRVPHFREIGDKIREKHDSSIEIKVNKRSR--------MR-----P-RKKSI-------------------------------------------------------------------------------------ESPTIT-D-LVH-LDSSP-DYCRANSRT-GVLG----TKGRECNA-H------------------------------SD-GSDG-CGLMC--CGRGYDTRVVDVEE-RCNC-RFQ------WCC--VVRCQK-CIKRVQRYICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt5b1_2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSK-PA-------------------FRESLKRLDKS----------------------------------VC--RT----L-DGLSQ------N-QRPLC------ERYIDHM-Q-FVSEGARIAVHECQHQFAGQRWNCSI-------------------------------T----D-DPNLFG--K--VI--K--------------------------VG-EKETAFTYALAASGAAYAVGRACKN-QKLPQ-C-G-C-SKQP-----------------------------KPD-GLR---------------------------------------------KD--------W-------KWAGC-GD-DTTYAYGFTREFVD-ARERDSV-P------------------------------------------K---RQRDRAIRAMNLHNNEAG-RA----AVL--RAARPACKCHGVSGS-----CSLKTCWMQVPDFREIGNKLRQEYKDAVKIRLTSRGR--------VK-----P-RSSS--------------------------------------------------------------------------------------KTVGIS-N-LVF-VESSI-DFCTANRRL-GTAG----TRGRECIE-N------------------------------ST-GENS-CGKLC--CSRGYTTTVVEVIE-KCNC-KFQ------WCC--VVKCQK-CKKKIKKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt5b1_2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTEVA-LFFCM-AMAMPFLASS---------HWWSSSK-PA-------------------FRESLKRLDKS----------------------------------VC--RS----L-DGLSQ------N-QRPLC------ERYIDHM-Q-FVSEGARIAVQECQHQFAGQRWNCSI-------------------------------T----N-DPNLFG--K--VI--K--------------------------VG-SKETAFTYALAASGAAYAVGRACKN-QKLPQ-C-G-C-SKQP-----------------------------KPD-GLR---------------------------------------------KD--------W-------KWAGC-GD-DTTYAYGFTREFVD-ARERDTV-P------------------------------------------K---RQRDRAIRAMNLHNNEAG-RA----AVL--RAARPACKCHGVSGS-----CSLKTCWMQVPDFREIGNKLRQEYKDAIKIRLTSRGR--------VK-----P-RSST--------------------------------------------------------------------------------------KSVGIS-N-LVF-VESSI-DFCMANRRL-GTAG----TRGRECIE-N------------------------------ST-GENS-CGKLC--CSRGYTTTVVEVIE-KCNC-KFQ------WCC--VVKCQK-CRKKIKKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt5b1_2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI-DR-------------------------------------SSSK-SA-------------------IRESLRRLDTN----------------------------------VC--DN----L-EGLSE------N-QRPLC------RRYINHM-Q-FVSEGARIGVQECQHQFRGRRWNCST-------------------------------T----D-DSNLFG--K--VL--K--------------------------VG-SKETAFIYALAASGAAYSVGRACKN-QKLPQ-C-G-C-SSQP-----------------------------KPA-GLH---------------------------------------------RD--------W-------KWAGC-GD-DTTYAYGFTREFVD-AKERDLV-P------------------------------------------D---SLRKRAIKAMNLHNNEAG-RV----AVL--RSARPACKCHGVSGS-----CSIKTCWHHVPDFREIGNKLMVEYKQAKKIRLTSRGK--------IK-----A-RSSNI-------------------------------------------------------------------------------------EQPTLS-N-LVF-IEASI-DYCFKNKKF-DLSG----TKGRECVE-K------------------------------IE-GEDS-CGVVC--CGRGYTTTTVEVVE-RCHC-KFQ------WCC--VVKCEK-CRNKIKKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt5a_4 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----------------------LRTYTVTIENVY-NFFHLQGLPS---------NFRSFAQ-RN-------------------DVEALGAELIT----------------------------------LC--DI----M-KGLSR------N-QKALC------KRYYSHM-T-YVRKGAMTGITECQSQFKSHRWNCST-------------------------------V----E-DSTVFG--K--VL--E--------------------------IG-SKEVAFTYAIASAGVVHEVARACKT-DAFPM-C-G-C-SANE-----------------------------RPE-GLD---------------------------------------------RD--------W-------EWGGC-GD-NTKYAYGFAKEFVD-AIERDNLSP------------------------------------------K---RSKDRARKAMNLHNNEAG-RM----VVV--RGTKPSCRCNGLSGS-----CSMKTCWSQVPDFKKVGKTLRENHAKAFEMKTNTRGH--------LR-----P-RRPRK-------------------------------------------------------------------------------------GIPTST-D-LIY-IEASP-DYCRPNRRT-GVPG----TTGRECHK-D------------------------------ST-DPNG-CGLLC--CGRGFERRKVEVVE-KCRC-KFQ------WCC--RVRCEK-CKRTVVKHICL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt5b1_3 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKG----------LQEMTSDMPKLKAIMLKLIFLL-IHCCLREVNG---------QWWSFSS-KD-------------------LKDLTQEDAAT----------------------------------VC--GR----L-GELSQ------N-QQTLC------SVYKSHM-P-FVGKGARMGAMECEWQLQGERWNCSALASQR-----------------------TD-G----V-ASRSYE--K--LN--M--------------------------IG-SAEAAFTYAIASAGIVYSIAKACKD-EKLVE-C-G-C-SQRP-----------------------------RPA-GIR---------------------------------------------QD--------W-------TWGGC-GD-NTEYAYGFSKEFVD-AKETEIQSS------------------------------------------R---KQKERARRIMNLHNNEVG-RL----AVV--HSLQPTCKCHGVSGS-----CSLKTCWYQIPDFRTIGNKLKAKYKLAGDIKVNKRGR--------IR-----Y-RATK--------------------------------------------------------------------------------------TVPSIS-E-LVY-VDSSP-DYCFKNTRF-GVSG----TKGRECNA-T------------------------------SS-GEDG-CGKLC--CGRGFKTRTIEIET-KCNC-KFQ------WCC--VVKCQK-CKEKIKKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt5b1_3 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRHRASVEQQKLYLIIKG----------LQEMTSDMPKLKAITLKLIFLL-IHCYLHEANG---------QWWSFSS-KD-------------------LKDFTREEAAT----------------------------------VC--GR----L-GELSQ------N-QQTLC------GVYKSHM-P-FVGKGARMGATECEWQFQGERWNCSVLASEK-----------------------TD-G----V-ASRSYE--K--LN--T--------------------------IG-SAEAAFTYAIASAGIVYSIAKACKD-EKLQE-C-G-C-SQRP-----------------------------RPA-GIR---------------------------------------------QD--------W-------TWGGC-GD-NTEYAYGFSKEFVD-AKETEIQSS------------------------------------------R---KQKERARRVMNLHNNEVG-RL----AVV--HSLQPTCKCHGVSGS-----CSLKTCWYQIPDFRTIGNKLKAKYNLAGDIKVNKRGR--------IR-----Y-RATK--------------------------------------------------------------------------------------AVPSIS-E-LVY-VDSSP-DYCFKNTRY-GVAG----TKGRECNA-S------------------------------ST-GEDG-CGKLC--CGRGHKTKTIEIET-KCNC-KFQ------WCC--VVKCQK-CKEKIKKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt5b1_3 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSLKKFAKYFSVMI-VFMCVGYTEA---------QWWLFSP-KD-------------------IRDFRTSESQT----------------------------------VC--SR----L-TGLSR------N-QRTLC------EVYPNHM-P-FVAKGAMMGAEECQWQFQGLRWNCSVLAPNQ------------------------D-G----D-NNNAYN--K--MV--S--------------------------IG-SKETAVSYAIASAGIVYSIAKACKN-EKLAE-C-G-C-SQHA-----------------------------RPE-GLG---------------------------------------------RD--------W-------NWGGC-GD-NTEYAYGFAREFVD-AKESNNVSP------------------------------------------Q---TQKSRDKRTMNLHNNEAG-RL----AVV--HSVHPACKCHGVSGS-----CSLKTCWMQIPDFRVIGKRLRKAYEDAVEAKITKRGK--------IR-----P-RSKT--------------------------------------------------------------------------------------NEITIK-S-LIH-LDASP-DYCFSSNRQ-GVPG----TRGRECNA-D------------------------------SE-KEDG-CGFVC--CGRGHTTQTVTVVE-RCNC-NFQ------WCC--VVKCEK-CQKTVKRHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt5b1_1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSFGAQQI-LVFIL-ASSAVYEANS---------HWWGYIA-EP-------------------LIAAHEKGLVV----------------------------------NC--EE----L-VGLSK------N-QISLC------RRYSDHM-Q-FVGEGARKGISECKWQFRHERWNCST-------------------------------S----T-RPDMFK--K--SM--K--------------------------IG-SREAAFTYAIAASAVVHSVGRACRS-GKLEH-C-G-C-SMHD-----------------------------RPE-GLR---------------------------------------------PE--------W-------EWQGC-SD-NTDHAYGFVREFLD-AKELD-IPM------------------------------------------T---DKHTKSRQVMNVHNNEVG-RL----SVV--RSSHPVCKCHGVSGS-----CSLKTCWMHVPEFRKIGDKLKEAYEQAVESKLSKRGV--------LK-----D-LHSPK-------------------------------------------------------------------------------------EFPPTS-S-LVY-LNSSP-DYCRPSKRM-GILG----TKGRVCNE-E------------------------------ST-GDDG-CGKVC--CGRRHTTSIVDVIE-RCNC-NFH------WCC--VVKCKK-CTRRIKQHVCT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt5b1_1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNEKLRKQ----FTI-ATRNM-----------------GYIA-EP-------------------LIAAHEKGLVV----------------------------------NC--EE----L-VGLSK------N-QISLC------RRYSDHM-Q-FVGEGARKGISECKWQFRHERWNCST-------------------------------S----T-RPDMFK--K--SM--K--------------------------IG-SREAAFTYAIAASAVVHSVGRACRS-GKLEH-C-G-C-SMHD-----------------------------RPE-GLR---------------------------------------------PE--------W-------EWQGC-SD-NTEHAYGFAREFLD-AKELD-SPM------------------------------------------T---DKHTKSRKIMNVHNNEVG-RL----SVV--RSAHPACKCHGVSGS-----CSLKTCWMHVPEFRKIGDKLKEAYDHAVESKMSKRGQ--------LK-----Y-RKSPK-------------------------------------------------------------------------------------ESPSTS-S-MVY-LNSSP-DYCSASKKM-GILG----TKGRVCNE-E------------------------------ST-GDDG-CGKVC--CGRRHITSIVDVIE-RCNC-NFH------WCC--VVKCDK-CTRRIKQHVCT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt5b1_1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-------------MFGKFDL---------------------------------------------------GYIA-QP-------------------LIEAFESDTPV----------------------------------IC--SE----L-HGLSR------N-QRTLC------ETYKDLM-P-YVGEGAKNGMEECEWQFKDQRWNCST-------------------------------A----T-NIELFK--K--IM--K--------------------------IG-SKESAFTYAVAASAVVHAVARACKN-GKVSQ-C-G-C-SVHP-----------------------------RPA-GLG---------------------------------------------RD--------W-------EWGGC-GD-NTEYAYGFAREFLD-AKELDNVSP------------------------------------------K---DPKSKSRKLMNVHNNEAG-RL----AVV--RSGHPACKCHGVSGS-----CSLKTCWMHVPELRRIGTRLKSAYVEAVEGKVSKRGQ--------LK-----D-RSQPS-------------------------------------------------------------------------------------SAPPVS-K-LVY-LDSSP-DYCTPNSRM-GVLG----TTGRICTE-N------------------------------SE-AEDG-CGRIC--CGRRHKTTIVEVIE-RCNC-NFH------WCC--VVKCDK-CKKKVKRHICT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt5b1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV--------------GMARIQSAEPVWILFVLAL-YSSVLMQVKP---------QLWSVGI-EK-------------------KKLFEDTNTSV----------------------------------QC--GE----I-RGLSR------N-QRSLC------RTYNDHM-Y-YVESGSKQGVEECQWQFRGKRWNCSL-------------------------------A----S-NASP-D--K--II--G--------------------------VG-SKETAFTYAITSGGVVQSIARACKS-GNLMA-C-G-C-SKRE-----------------------------RPL-GLG---------------------------------------------KD--------W-------NWGGC-GD-DVDYAYGFAHEFID-AQERDSSSP------------------------------------------N---DRRVKSHKAMNIHNNEAG-RL----SVV--RAAHTTCKCHGVSGS-----CSIKTCWLQTPQFRTIGDKLRQRYDDALEMRVTHRGQ--------MK-----T-RFSSD-------------------------------------------------------------------------------------RNPSNI-D-LVY-IDSSP-DYCKVNQKL-GILG----TSGRECQL-D------------------------------SI-AMDG-CGLMC--CGRGYTTKMVEVVK-SCNC-KFQ------WCC--FVKCQQ-CKEKVLKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt5b1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV--------------GMTRIQSAEPVWILFVLTL-YSSVLMQVKP---------QLWSVGI-ER-------------------KKLFGETNTSV----------------------------------QC--DE----I-RGLSR------N-QRSLC------RTYNDHM-Y-YVESGSKQGVEECQWQFRGQRWNCSL-------------------------------A----S-NASP-D--K--II--A--------------------------VG-SKETAFTYAITSGGVVQSIARACKS-GNLMA-C-G-C-SKRE-----------------------------RPT-GLG---------------------------------------------KD--------W-------NWGGC-GD-DIDYAYGFAHEFID-AQERDNSSP------------------------------------------N---DRRVKSHKAMNIHNNEAG-RL----SVV--RASHTTCKCHGVSGS-----CSIKTCWLQTPQFRTIGDKLRQRYDDALEMRVTHRGQ--------MK-----T-RFSSD-------------------------------------------------------------------------------------RNPSNI-D-LVY-IDSSP-DYCKVNHKL-GILG----TSGRECQL-D------------------------------SL-AMDG-CGLMC--CGRGYTTKMVEVVK-SCNC-KFQ------WCC--FVKCQQ-CKEKVLKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt5a_3 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEILNRLFIL-LVINVTSVKP---------HWWSMTV-RQ-------------------PTDDVVYRRFS----------------------------------AC---E----T-EGLSR------N-QKALC------MRYYSHM-G-YVSDGARTGIHECQHQFKGHRWNCST-------------------------------V----N-DNSVFG--K--VI--K--------------------------TG-SRETAFTYAVASAGVLYSVAKACRG-DTLPG-C-G-C-SEQA-----------------------------RPE-GLN---------------------------------------------ED--------W-------VWDGC-GD-DTNYAYGFSREFID-AHERDNLSP------------------------------------------R---GKKKKARKQMNLHNNEAG-RM----MVV--RLTRPSCKCHGVSGS-----CNLKSCWMKLPDFRQVGSKLRRQHKVAVKMTPTKKGT--------LK-----P-RRASH-------------------------------------------------------------------------------------EAPAIT-D-LIY-IESSP-DYCKKNSRT-GVPG----TRGRECVL-N------------------------------SK-GLDG-CGLLC--CGRGYTQKEITYDV-QCHC-KFQ------WCC--SVRCDT-CTRQVTKYFCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt5a_2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEILNRLFIL-LVINVTSVKP---------HWW-----RQ-------------------PTDDVVYRRFS----------------------------------AC---E----T-EGLSR------N-QKALC------MRYYSHM-G-YVSDGARTGIHECQHQFKGHRWNCST-------------------------------V----N-DNSVFG--K--VI--K--------------------------TG-SRETAFTYAVASAGVLYSVAKACRG-DTLPG-C-G-C-SEQA-----------------------------RPE-GLN---------------------------------------------ED--------W-------VWDGC-GD-DTNYAYGFSREFID-AHERDNLSP------------------------------------------R---GKKKKARKQMNLHNNEAG-RM----MVV--RLTRPSCKCHGVSGS-----CNLKSCWTKLPDFRQVGSKLRRQHKVAVKMTTTKKGT--------LK-----P-RKAPH-------------------------------------------------------------------------------------EAPAIT-D-LIY-IESSP-DYCRKNSRT-GVPG----TKGRECDL-N------------------------------SK-GLDG-CGLLC--CGRGYTQKEITYDV-QCHC-KFQ------WCC--SVRCDT-CTRQATKYFCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt5a_1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDTRSRKVAIVFTLV-MVIMVEEASA---------HWWSLASPRA-------------------HLTNMTAYRTE----------------------------------MC--DA----E-GVFSR------N-QKALC------KRYHNHM-E-FVREGALNGIGECQHQFSDHRWNCST-------------------------------V----K-DNSVFG--N--VL--D--------------------------IG-SKEIAFAYAVASAGVVHAVTKACQT-GHL-E-C-G-C-TTKP-----------------------------RPK-GLQ---------------------------------------------PD--------W-------SWEGC-RE-DTSYAYGFAQEFID-AHERDNLSP------------------------------------------R---GRKAKARKAMNLHNNEAG-RM----TVV--RSARPACKCHGVSGS-----CNMKSCWNRLPDFRSIGQVLRQAHIDSVDMRITKKGQ--------IK-----V-RRPARHG----------------------------------------------------------------------------------STKADLT-D-LVY-IEASP-DYCHKNIRT-GVPG----TRGRECDK-K------------------------------SR-GADG-CGLLC--CGRGYSKKKVVIYK-ECNC-KFQ------WCC--TVKCET-CKEEITKHICH---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt5 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MF-----------------SNSRVSLKFFTILAYI-AVACVSQVNS---------HWWSLAT-KT-------------------L--LVGSSSVE----------------------------------QC--DN----E-LGFSH------S-QRQLC------RTYANHM-K-YVKDGAENGIKECKYQFRLNRWNCST-A-----------------------------V----N-DITVFG--K--VL--K--------------------------IGKSQETAFTYAVAAAGVVVSVAQACKN-GLLQE-C-G-C-SRAP-----------------------------RPQ-GIS---------------------------------------------SS--------W-------NWGGC-GD-DTDYAYGFAKEFID-ARERDTNPS------------------------------------------N---KSKHKARKEMNLRNNEAG-RL----VAV--RSSEPTCKCHGVSGS-----CNVRTCWMKLSGFREIGNKLKNKYNSAIEVVAKKRGR---------RQLDFTP-RKRTD--------------------------------------------------------------------------------------VITPT-S-LVY-LESSP-DYCMKNRRT-GVKG----TKGRECNV-D------------------------------SN-GPDG-CGLMC--CGRGYRVVHKQIVE-KCNC-RFQ------WCC--TVICDQ-CPSNVKRYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt5 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MF-----------------SNSRVSFQFVTILTYI-TVVCVSQVNS---------HWWSLAT-KT-------------------L--LVGSSSVE----------------------------------QC--DN----E-LGFSH------S-QRQLC------RTYANHM-K-YVKDGAENGIKECKYQFRLNRWNCST-A-----------------------------V----N-DITVFG--K--VL--K--------------------------IG-SKETAFTYAVAAAGVVVSVAQACKN-GLLQE-C-G-C-SRAP-----------------------------RPQ-GIS---------------------------------------------SS--------W-------NWGGC-GD-DTDYAYGFAKEFID-ARERDTNPS------------------------------------------N---KSKHKARKEMNLRNNEAG-RL----VAV--RSSEPTCKCHGVSGS-----CNVRTCWMKLSGFREIGNKLKSKYNSAIEVVAKKRGR---------RQLDFTP-RKRSD--------------------------------------------------------------------------------------VITPT-S-LVY-LESSP-DYCVKNRRT-GVKG----TKGRECNV-D------------------------------SN-GPDG-CGLMC--CGRGYRVVHKQIVE-KCNC-RFQ------WCC--TVICDQ-CPSNVKRYVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt5b2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAT-------------VLRKSSDLDSKW--MAILI-IASLASQVHS---------EWWSMGR-NE-------------------ATLEQAANRLI----------------------------------PC--SE----I-KSLSR------S-QRTLC------ESYRDHL-K-FVSEGASEGVAECQHQFRHRRWNCTTTATNTG--------------------SNGT-G----S-EKPLFG--K--VI--D--------------------------IG-SRETAFTYAISAAAVVHNIARACKM-GELSN-C-G-C-SDEP-----------------------------RPR-GLG---------------------------------------------PN--------W-------SWGGC-GD-NTMYAYGFAREFID-ARERDLASPL-----------------------------------------S---GAQSRGRKAMNVHNNEVG-RL----AVV--RGARPTCKCHGVSGS-----CSINSCWWQTAQFRTIGDTLQKKLTEAVEVKMTRRHG--------LR-----S-RRRVD-------------------------------------------------------------------------------------GSISDS-K-LVF-LESSP-DYCTPNPAT-GVVG----TTGRYCNK-D------------------------------ST-GPDG-CGLLC--CGRPHASYTEVITE-RCHC-KFH------WCC--HVKCEV-CRKRVKRHVCT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt5b1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTHFYAITGLFA-IALLPCSTYG---------QLWTLAH-SN-------------------L--SLSEEKSV----------------------------------KC--SS----L-MGLSR------T-QRPLC------RRYNDHM-T-FVSSGAQTGLEECKHQMRTNRWNCTV------------------------------------P-STASAS--K--SL--D--------------------------VG-SREVAFSYAITAAGVVHAIARACKN-GELSEHC-A-C-SRRA-----------------------------RPR-GLS---------------------------------------------PT--------W-------KWGGC-GD-DTDYAYGFSYEFID-ANEKGNRS-------------------------------------------R---NRRETARRNMNLHNNEAG-RL----AVF--RMTRPTCKCHGVSGS-----CSLKSCWMQVPDFREVGRRLHAQYAAAMEVKSTGSGK--------LR-----P-RFTSS-------------------------------------------------------------------------------------KDPAPT-D-LVY-LDSSP-DYCIPNPNM-GVLG----TSGRDCEM-Y------------------------------SP-GMDG-CGIMC--CGRGYSSRDIVIET-TCRC-KFQ------WCC--SVKCDT-CRKQVRKHICH---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt5 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----------------------------------VLTSFFHAGH---------SVWSVNI----------------------PHQAYIISVQPG---------------------------------LC--MN----L-GGLTR------E-QIDLC------QKNIDHM-A-SVGLGAKMAIQECQFQYQYEKWNCSI----------------------------PD-A----E-KSSLFE--R--ITSKD--------------------------VA-TREAALTYAISSAGVVWALARACTE-GNLST-C-S-C-SRER-----------------------------RPL-DLN---------------------------------------------KE--------Y-------QWGGC-GD-NIEYAVKFGREFME-AGEDHRPTE------------------------------------------E---DRKKYARTLMNLHNNNLG-RR----VVK--DISVVECKCHGVCGS-----CNLKTCWRQLVEFREIGNALHDKYDAAVQVALKRKEGRSL--LLPMRSRHYSQ-RKAKS-------------------------------------------------------------------------------------AQETRD-E-LVY-IDKSP-DFCSKNAAH-GAQG----TRGRKCIK-E------------------------------SL-GKDG-CNLLC--CSRGYKMKKEVQAT-RCRC-KFH------WCC--KVKCKT-CIKNVTTHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT6 M-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPPLPSRLGLLLLLLLC--------------PAHVG------GLW---W----------AVG-SPLVM------------------------------DPTSIC--RK----A-RRLAG------R-QAELC------QAEPEVV-A-ELARGARLGVRECQFQFRFRRWNCSSH-------------------------------------SKA-FG--R--IL--Q--------------------------QD-IRETAFVFAITAAGASHAVTQACSM-GEL-LQC-G-C-QAPR---GRAPPRPS------GLPGTPGPPGPAGSP-EGS---------------------------------------------AA--------W-------EWGGC-GD-DVDFGDEKSRLFMD-A------------------------------------------------RHK---RGRGDIRALVQLHNNEAG-RL----AVR--SHTRTECKCHGLSGS-----CALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPA--------VRT-LKP-----------------------------------------------------------------------------------------PGRA-D-LLY-AADSP-DFCAPNRRT-GSPG----TRGRACNS-S------------------------------AP-DLSG-CDLLC--CGRGHRQESVQLEE-NCLC-RFH------WCC--VVQCHR-CRVRKELSLCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt6 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGCITCKA---------CYLPSHISYQTAMEGDWQERW----------AVG-SPLVM------------------------------DPNSIC--RK----T-KRLAG------K-QAELC------QTQPEIV-N-EVAKGAKLGVRECQYQFRFRRWNCTSQ-------------------------------------NKY-FG--K--IL--Q--------------------------QD-IRETAFVYAITAAGVTHAVTQACSM-GEL-LQC-G-C-EATR---SRGPP----------------PRLASMGP-TEG---------------------------------------------VK--------W-------EWGGC-GD-DVEFGYEKSKQFMD-A------------------------------------------------RRR---KGKSDIRTLIDLHNNEAG-RL----AVK--NYMRTECKCHGLSGS-----CTLRTCWKKMPHFREVGDRLLERFNGASKVMGGNDGKTLIPV--------GQN-IKP-----------------------------------------------------------------------------------------PDKQ-D-LIY-SAESP-DFCLPNRKT-GSLG----TRGRTCNS-T------------------------------AL-DVSG-CDLLC--CERGHRDETVVLEE-NCLC-RFH------WCC--VVQCKK-CLVRKELSLCQ---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt6 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASAHLVFTVFFFYLLC--------------PTSII------GLW---W----------AVG-SPLVM------------------------------DHRSIC--RK----T-RRLIG------K-QAEIC------RKEPEIV-H-EVIKGAKLGTGECQFQFKERRWNCSTA-------------------------------------DKF-FG--R--IL--N--------------------------QD-IRETAFVYAVTSAGVTFAVTQSCSM-GEL-LQC-G-C-DYQM-----------------------------KGE-SPD---------------------------------------------GS--------W-------EWGGC-GD-DIDFGYTKSREFMD-A-------------------------------------------------QT---RHRSDIRTLLTLHNNEAG-RL----AVK--NFMRTECKCHGLSGS-----CAVKTCWKKMPIFREVGVRLKERFNGAFQVMGSNNGKYLIPV--------GDT-IKA-----------------------------------------------------------------------------------------PTAE-D-LVY-TNESP-NFCKRNRKT-GSQG----TKGRACNA-T------------------------------SM-GIGG-CDLLC--CGRGYKERQVVVEE-NCKC-RFH------WCC--VVKCSK-CTAVKTVHECL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt6 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASAQLAFTVFFFYLLC--------------PTSII------GLW---W----------AVG-SPLVM------------------------------DHRSIC--RK----T-RRLIG------K-QAEIC------RKEPEIV-Q-EVIKGAKLGTGECQFQFKERRWNCSTA-------------------------------------DKF-FG--R--IL--M--------------------------QD-IRETAFVYAVTSAGVTFAVTQSCSM-GEL-LQC-G-C-DYQM-----------------------------KGE-SPD---------------------------------------------GS--------W-------EWGGC-GD-DIDFGYTKSREFMD-A-------------------------------------------------QT---RHRSDIRTLLTLHNNEAG-RL----AVK--NFMRTECKCHGLSGS-----CAVKTCWKKMPIFREVGVRLKERFNGAFQVMGSNNGKHLIPV--------GDT-IKA-----------------------------------------------------------------------------------------PTAE-D-LVY-TNESP-NFCKRNRKT-GSQG----TKGRACNA-T------------------------------SM-GIGG-CDLLC--CGRGYKERQVVVEE-NCKC-RFH------WCC--VVKCSK-CTAVKTVHECL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt6 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAPTQLVFTVFFFYLLC--------------PTSII------GLW---WAETLNQISHRAVG-SPLVL------------------------------DHRSIC--RK----T-RRLIG------K-QAEIC------RKEPEIV-Q-EVVKGAKLGTGECQFQFKERRWNCSTA-------------------------------------DKF-FG--R--IL--T--------------------------QD-IRETAFVYAVTSAGVTFAVTQSCSM-GEL-LQC-G-C-DYQM-----------------------------KGE-SPD---------------------------------------------GS--------W-------EWGGC-GD-DIDFGYTKSREFMD-A-------------------------------------------------QT---RHRSDIRTLLTLHNNEAG-RL----AVK--NFMRTECKCHGLSGS-----CAVKTCWKKMPIFREVGVRLKERFNGAFQVMGSNNGKYLIPV--------GDT-IKA-----------------------------------------------------------------------------------------PTAE-D-LVY-TNESP-NFCKRNRKT-GSQG----TKGRACNA-T------------------------------SM-GIGG-CDLLC--CGRGYKERQVVVEE-NCKC-RFH------WCC--VVKCSK-CTAVKTVHECL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt6 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMAKTTIFLALFLLLLL--------------PAKII------GLW---W----------AVR-SPFHL------------------------------DQNKIC--KV----S-RKLGG------RLQKEIC------RKEPEIV-K-EVVKGAKLGTGECQYQFKNRKWNCTTN-------------------------------------NDS-FG--K--IL--L--------------------------QD-TRETAFVCAVTSAGVTYAVTQACSM-GEL-LQC-G-C-DDEV----------------------------SRHA-GSN---------------------------------------------ST--------W-------EWGGC-AD-NIEFGYQKSKEFMD-A-------------------------------------------------QD---KRRSDIRTLINLHNNEAG-RL----AIK--KNMRIECKCHGLSGT-----CTVKTCWQKMPVFRFVGNRLKEKFNRATEVIGGNDGNELLPE--------GET-IKP-----------------------------------------------------------------------------------------PTDE-D-LVY-TAKSP-DFCEPNRRV-GSLG----TGGRNCNN-T------------------------------SL-DVGG-CDQLC--CGRGYKEETITVTE-NCKC-RFH------WCC--VVNCDT-CTTKKTIHKCNGYRS------------------------------------------------------------------------------------------------------------------------------------------------------------ Lgi_Wnt6 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRVQGVLIGLYFYLIF--------------PANII------GLW---W----------AVG-SPLVM------------------------------DTNSIC--RK----T-RRLAG------K-QRAIC------RKEPEIV-E-EVAKGAKVALMECQYQFRTRKWNCTTL-------------------------------------RRS-LS--K--IL--R--------------------------RD-TREAAFVYAITAAGVVYAVTEACSM-GRL-LQC-T-C-DNNL-----------------------------RDI-ATD---------------------------------------------GE--------W-------EWGGC-GD-NVDFGYQKSREFMD-A--R---------------------------------------------RRK---RRRGDVTTLVQLHNNEAG-RQ----AVR--KYMRKECKCHGLSGS-----CTLKTCWRKMPLFRDVGNRLKQKFDGGSKVISSNDGKYLIPE--------GDT-IKP-----------------------------------------------------------------------------------------PSKE-D-LVY-SEESP-DFCRRNKKE-GALG----TRGRECDP-T------------------------------SM-GVGG-CDLLC--CGRNYSKKQVTIKE-NCNC-RFM------WCC--EVICET-CQKIKTETRCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt6 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSEGAWVCLVFYLIC--------------PANII------GLW---W----------AVG-SPLVM------------------------------DPNIIC--RK----S-RKLGG------K-QHEMC------RNEPEIV-E-EVANGAKMAISECQHQFRHRRWNCTTA-------------------------------------NRS-IQ--R--VL--K--------------------------HD-TREAAFVHSLTSAGVLYAVTQACSL-GLL-LQC-M-C-DNSV-----------------------------MDR-STD---------------------------------------------GK--------W-------EWAGC-NE-DVRFGSRKAAEFLD-I-------------------------------------------------PP---TQRNDVQGRILLHNNKAG-RA----SVA--KYQQKICKCHGLSGS-----CELKTCVLKMPSFRDVGDRLKERFDGAYKVSIANDGRNIIPIED------HDA-ARR-----------------------------------------------------------------------------------------PSGE-N-LVY-LDESP-SFCKPSRKQ-GSLG----TLDRLCNP-D------------------------------TS-TTDS-CDIMC--CGRGYRSYKVVVQE-NCRC-QFK------WCC--KVICQT-CSRTLSIHRCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt6_like ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSKQK--HVTWFHVIL--------------FTTLI------PLQ---R---------RVNG-NPLVM------------------------------DPNSIC--RK----T-RMLAG------R-HTDLC------QSQPEII-Q-EVAKGARLGIRECQHQFHNHRWNCTSQ-------------------------------------GRN-LA--K--IL--Q--------------------------QD-IRETAFVYAVTAAGVMHAVTQACSQ-GAL-PQC-G-C-VTLQ---SSSETYR-------VSPAEEVL--IQASS-LHD---------------------------------------------WH--------W-------EWGGC-GD-DVDFGYEKSRQFMD-I------------------------------------------------RQR---KGKSDIRSLIDLHNNEAG-RV----AIQ--IQMRTECKCHGLSGS-----CTLRSCWKKMPLFRQVGDQLMQSFHTAVRVMGGNDGKSLVSI--------DPD-APP-----------------------------------------------------------------------------------------LDAN-V-LIY-SAESP-DFCKANHRS-GTEG----TGGRACNR-T------------------------------ET-GPGG-CDSLC--CGNGFADFTVEEEE-NCEC-RFH------WCC--EVQCQT-CSQRKNVSLCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt6 M---------------------------------------------------------------------------------------------------SSNTDADAMK---------------------------DAPLPCRR------PK-------------------------------------------------------------------------------------------------------------------------------------------------LLPRLLH--------------SADPS----------------------RAYE-TPFELN--------------------------PKTNPNAVC--K-------RII----------GTDFC------NSRPGIV-S-KVLEGIASSVEECQNRFRNRKWNCTTQ-------------------------------------KRS-LR--K--IL--Q--------------------------HD-YRETAFVFAITSAGITFTVSKACSL-GEL-QGC-G-C-NARKGLDISSSNLVPQGRDELQYEKRSLHENAMGLD-EAER--------------------------------------------HD--------F-------GRRGC-QHVYTQFGFDTAKQFMD-P------------------------------------------------------MGSRDAKALISRHNNKAG-RL----AVK--NHMEKKCRCHGLSQT-----CQMKTCWWELPAFRSVSDRIKTHFDGAVKVYVDNKGERIIAE--------EST-VKP-----------------------------------------------------------------------------------------PTEE-D-LVY-TTRSP-DFCNSEYRT-GSLG----TRGRTCNE-T------------------------------SQ-GTGG-CELLC--CGRGYERTVINEEV-NCRC-RFH------WCC--EVRCKK-CKKERVVFTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt6 MTLQRS-CFVDLSEKRDMSDVGGATYDEE------------------------ALSVSEML--SSHMDVSRATELSQSMASERFSPTESPIT-------ACCSADQTGIF----------------------------SCTFCRK------PLRAANTIRRSKLR----SRNLDDCG--TAPHESTAVTSTDRSDN-------------------ELEMRLGQNRSINSEHSEAVMQNDSDIPNLSSENLC-----------RKHRRNSVERGVTKQSTWRVHRRILPAIHSSVTIVLLQVLLFC--------------TVNVA------AVW---W----------NPGYRPTLM------------------------------DSERIC--LW----A-QQIGG------P-QAEMC------ANEMPVV-E-EIKKGIQRGAYNCAREFRYSRWNCSQT-------------------------------------PKKFYE--K--AL--W--------------------------QT-TKETSYLQAVTSAAMTFAITEACSL-GNI-PEC-G-C-VNTR---GQKREYLRR-----EAQKRNYYINESYLD-TFV---------------------------------------------DQ--------F-------DWEGC-DD-NVDFAYRKTRHFLN-F-TRF--------------------------------------------IGR---KRKINLRLRMSAHNYEAG-RL----AIT--EKMAEKCKCHGFSGT-----CTIRTCWMRMPKFDAVRATLRRMYNTATKVNLQPGTRRLVIA--------RRP-RRPS-----SRHR----NTASRRTNKVKRGLRKNIPTRF---------------------RSRNRKAKNPRRRIR----LKN--RLRRRLYPVASK-H-LVY-HQPSP-NFCRRDKRK-GSLG----TKGRVCDP-TR-----------------------------RE-GYGS-CQYMC--CGRGYTTEVVEHTM-KCNC-TFI------YCC--TMTCDE-CINRYTRYVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt6 -----------------------------------------------------------------------------------------------------CHAATTAIS----------------------------SCKFCRK------PIRRSTTFCRPKHKILEALPNSDDCG--LKPQKKSIETITNPMKN-------------------DLQMRLCPNQQKTQTHSEATTNENV---IFRTKSRT-----------QKQHSKSKERRKIDGTAWSKHRRLFPAFRSSVTILLLQVLIFC--------------TANVA------AVW---W----------SPGNRPGLV------------------------------DSERIC--LW----A-RQIGG------Q-QAEMC------RNELSVV-N-EIRKGIQNGAYNCAREFRTSRWNCTQT-------------------------------------PKNFYA--K--AL--W--------------------------QT-TRETSFVQAVTSAAMTYAITIACSH-GDI-PEC-G-C-VNTR---ALKKEFLRR-----EAQKRNHYINESHLE-SIV---------------------------------------------DK--------F-------DWEGC-DD-NVAFGYQKTRQFLN-L-TRF--------------------------------------------IGR---KRKVNLRLRLSQHNYEAG-RL----AIT--GNMKRKCKCHGLSDT-----CTLRTCWLRMPSFDEVRANLRRKYESAVKVNMQPGSQRFVAA--------GQP-RRSS-----NRRR----ISRLRRPNKVRRSVNKNFPN-----------------------RSRYRKAKALRRRAR----LRNNKRRRRIFPAITNA-D-LVF-HQVSP-HFCRRDRRR-GSLG----TKGRVCDP-T------------------------------RE-GPGG-CGYMC--CGRGYKREVVVVKK-KCNC-SFK------YCC--KVTCDE-CINRYTQYICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt6 M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFIYLFI-I---------IYYVSSNSY-GKFEIIFNNKY------YVFSVLG-SSLLF------------------------------NPADFC--GR----G-RLLSR------T-QQEIC------RNYSHLV-K-YVEEGVRLGSKRCQNEFQYNRWNCSNT-------------------------------------PKPYYG--R--LL--T--------------------------QD-TRETSYLGAVTSAAVTYTITYACST-GAI-EEC-G-C-GDER---VGSYHLLKQ-----EAIKRNMKVNESDLL-RAA---------------------------------------------ST--------F-------KWGGC-SD-NIDYGYRMSRLFLG-NFGRQ--------------------------------------------KQ----SERGELKNLVEKHNYEAG-RL----VIK--NHMIRQCRCHGISAS-----CALETCWNKMQKWQNIGNIMRKRYDGAIRVHLGNDGRSLLPS--------RRQ-RKHFKQYWFNRKSHATDVALNRRYKRAAPMRPGIYPPKMGTTSLKVVKDRADSGHDTLPTRGPVLRLLRSRRRHRRGG--------ADRKIVITGE-H-LIY-SQDSS-NFCKRSRRQ-GSLG----TRGRRCIP-H------------------------------VS-GPGN-CDYLC--CGRSYTQHQIRVTK-SCNC-RLR----TDYCC--ELICDD-CSVLETVYTCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt6 M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SF----------------IYY-----Y-SEFDIIFNKKY------FVLSVLG-SSLLF------------------------------NPDDFC--GR----G-RLLSR------T-QQEIC------RNYSDLV-K-YVEEGVRLGSKRCQNEFQYNRWNCSHT-------------------------------------PKSYYG--R--LL--T--------------------------QD-TRETSYLSAVTSAAVTYTITYACST-GAI-EEC-G-C-GDER---VGSYHLLKQ-----EAIKRNMKVNESDLL-RAA---------------------------------------------ST--------F-------KWGGC-SD-NIDYGYRMSRLFLD-NFGRQ--------------------------------------------KQ----PERGELKNLVEKHNYEAG-RL----VIK--NHMIRQCRCHGISAS-----CALETCWNKMQKWQNIGNIMRKRYDGAIRVHLGNDGRSLLPS--------RRQ-RKHFKQYWFNRKAHATDVTLNRRYKRAAPMRPGIYPPDMGTASLKVVKDRADSGRDTLQTRGPVLRLLRSRRRHRRGG--------ADRKLVITGE-H-LIY-SQESS-NFCKRSRRQ-GSLG----TRGRRCIP-H------------------------------VS-GPGN-CDYLC--CGRSYTQHQIRVTK-SCNC-RLK----TDYCC--ELICDD-CSVLETVYTCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt6 MYFGNQ-----------IHRSMLTTVEISRSNLEIE----RHLEVNEAE----FNPNSRQLEKESHER------NYRNIPTEFYGMNDVTVSSY-----DDGNIITINVGVEKG--GTNCDPHKTKTNLR--SLSTVPTSLSWSGEIRKSSNIFLNNI----------------------------SIHDKKNINAK---HNQCYKRRALKCYR-NFKANVNKTETSEIFPGHSRFNICTNFQIVIS--------ILFF--------------CGRQLTRHKT--------WSNLLMKIFFILFV------------AFPVSPA----------------------RGFE-NMEII------------------------------NPKQYC--QR----A-PHLTP------Q-QRVLC------RLDTKMF-K-YIEEGVLLSSKQCSKEFKHERWNCTRS-------------------------------------PPSFFK--S--LV--N--------------------------QD-TKESAFVHALASAAVSHAVTTGCTK-GDL-LEC-G-C-DDTQ---IRSYDLLRQ-----EAARRKLVVNETLLR-RAA---------------------------------------------SE--------F-------KWNGC-GD-NIDYGYKMSRHFFN-N------------------------------------------------------NQQGDIKTIVVQHNYEAG-RL----AIK--NHMERTCKCHGLTGT-----CTIHTCWQKMPKFIETSSRLHWRYNAALPVKMNNDMSSLTVS--------RSL-RRR------ARKR-----LSTRRGKRDAPLAPK----------------------------ADFEEAKTRTKRRKRGETYSIKTRRRLRKHMLSAE-D-LVY-SEPSL-SFCNRVKKG-GSLG----TARRVCNP-N------------------------------IT-GAGS-CDRLC--CGRGHVATTVLKTK-PCRC-KFK------YCC--EVICDE-CTVESIIYTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt6 M----------------------ATVEISRSNFEIE----RCLEANKGR----FNPNTRQLDKESHER------NYTNIATEFCSMNEVSVSTC-----DGNIITTTNADAKQG--GTNCHPHKNQTNIR--SLSTVPTSLSWSRNITNSSNIFINNIFSSSRSTTTSALPN-------HCTSSSGAIYKTFTLEDK---HNTCYKRRALKCYR-NFKANVDRSETS---AGHSHINLFSNFQILFS--------LFFV--------------CGGQLTGHKT--------RSSLLMKIFLILFV------------AFPVSPA----------------------RGFE-NMEIV------------------------------NPKQYC--QR----A-PNLTP------Q-QRVLC------RLDTKMF-K-YIEEGVLLSSKQCSKEFKHERWNCTRS-------------------------------------PPSFFK--A--LV--N--------------------------QD-TKESAFVHALASAAVSHAVTTGCTK-GDL-MEC-G-C-DDTQ---IRSYDLLRQ-----EAARRKLVVNETLLR-RAA---------------------------------------------SE--------F-------KWNGC-GD-NIDYGFKISRHFFN-N------------------------------------------------------NQQGDFKTRVVQHNYEAG-RL----AIK--NHMERTCKCHGLTGT-----CTIHTCWQKMPKFVETSSRLHWRYNAALPVKMNNDMSSLTIS--------RSL-RRR------ARKR-----LSTRRGKRNAPLSSK----------------------------ADIDEAKTRTKRRKRGETYSIKTRRRLRKHLLSTE-D-LVY-SEPSL-SFCNRVKKG-GSLG----TARRVCNP-N------------------------------IT-GAGS-CDRLC--CGRGHVATTINKTK-PCRC-KFK------YCC--EVICDE-CTVESVIFTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt6 K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIYYLCF------------------------------------------RGFD-SMELI------------------------------NPRSFC--QT----S-RYLSP------Q-QRVLC------RMESKMF-K-YIEEGILLSTRQCSKEFKNNRWNCSRN-------------------------------------PLSFFR--A--LV--N--------------------------QD-TKESAFVHAIASAGVTYAVTTGCTK-GDL-LEC-G-C-GDSR---VRSYDLLRQ-----EAARRNIEINETLLL-RAA---------------------------------------------AE--------F-------KWGGC-GD-NIDYGYKMSRHFFD-G------------------------------------------------------NERGDLKTRVVKHNYEAG-RL----AIK--KHMKNSCKCHGLSGS-----CTIHTCWQKMPKFSEISSKLHWRYDNAIPVKMNNDIRSLSIS--------RAL-WRR------NAERQ--RNLKRQRGRKRRDSSFKHPSNNF---------------FDEFDISSNITEPHVRIKRRRRGGAYSVRSRKAFRKHILSDE-D-LVY-SQSSP-DFCTKMKRS-GSLG----TQGRQCEP-N------------------------------GT-GAGS-CSELC--CGRGYVKKKTTVTK-PCRC-NFK------YCC--EVVCEE-CEVDTLIYEC----------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt6 MDYTKSRDVIGLKESNNLRRTQLRSLDHERNDSAVHVNSTRHLKDHDSNRAKLYASTNGLLNVETHVQEKRARKNPPAIICNRTSLQKLLVS-------DADLVNSEGVD--------NCCPWQYVTNDREKNISIAQGSHYCRRNF---DRIKCNNPICDESSHL--NSRNFTDF--------SKSKTPRERLNESIKGLGTLQRRTSSLCHLVQVDENVNDVRTCGRTSSENVSRESSSFRDIILWTVIYFGYLLNA--------------CRFQRQYNSTRKRL-SISRNSAFLLLFTFLLI--------------RADCK----------------------RVLG-NSLLL------------------------------SPGRLC--MR----P-RYLNS------K-QMEIC------RNSTELL-E-IVKQAVIIGSFSCQNEFRFNRWNCTSS-------------------------------------PKNYYG--R--LL--Q--------------------------QD-VRETAYITALTSASITYRFTAACSR-EEV-ENC-G-C-LDDY---ISSYDLLKE-----EAKKMHLKVSELELR-QAA---------------------------------------------KT--------F-------DWGGC-RD-LLSYGDRVSTLFTE-NFGR---------------------------------------------K-----HESFDLKGKIEKHNLKYG-RK----AIA--NLMRNKCKCHGVTGS-----CTLTTCWDTLPAWEDVTRHLRSKFESAIKVQLANDGNSLLPT--------RRQ-RLAIRE----------------------------YPPAY---DLRAMWD---------PTSGRLSQPKSLRRRWKR---MRRNLRKIANSRAVAED-E-LVY-SEESP-NFCKKVKKH-GTLG----TEGRRCIP-H------------------------------TT-GSGS-CSYLC--CGRGASLGYINETY-SCNC-DFS------HSSSRQLTCDN-CTRQKSVYYCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt6 MCRGKS----------------------------------------------------RPFPTDIYSR-----------ITEGGRFGEMRLGKQICYQPGSQSTDAAAVALSPRRESQSVTPPTSAGSF---------PATYCRK------RRAIEDRTARRSVDAV-ISRDSDKYGNITATGDSTGRLATNLVSC-------------------TEEPLLEPSKRRSIELS-------TPVRAGQATS---------------YHRRTTVRGMTSSHTSSPTRIRAGNFGLSRFSMAVVLLLCC--------------LSGAS------AMW---W----------SPGSDAKLI------------------------------DTRKLC--HW----A-RRSGG------D-AARMC------RKDPKTV-N-EIRQGIDRGLRSCSEDLRHDRWNCSQS-------------------------------------KKVYFG--N--VM--R--------------------------KD-LRETAYVQALTAAAVTYQITLACTK-GRL--DC-G-C-SEIA--KQQRRSILLM-----EAQKRRRTVDMDRLD-ELV---------------------------------------------EE--------F-------EWGAC-GD-NVEFGRLKAMQFMD-IQRR---------------------------------------------KME---AAKGNITEAVYVHNFEAG-QM----TIV--DNMRNKCQCHGLSGS-----CTLWTCWPIMPRFVEVRQRIRHKYDYAIRVQSSANGASLVPR--------MRS-RPRF-----PRHS-----LATNRLQGAT------------------------------FGYARHRARNKLVRGNR----VRTVERKRRGARAVRPN-D-LIF-LQSSP-RFCAPNKSK-GSLG----TFGRRCDP-S------------------------------TT-GLGS-CSYLC--CGRGYREEVHTFTE-KCNC-QFV------YCC--ELKCED-CVRREKRYYCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt6 MSRAKS----------------------------------------------------QPLPADIYSR-----------ITERTSLDDMSRAKQICCQRGSQLSDTVAAATKLR--SQSVTPQSSRGSF---------PATYCRK------RRAIEDRTARRGVDAI-ISTDSDKYSNITTTWDSTERLATDQFSS-------------------STDLVLEPSIPRSFELSK-----FSTISRQQLEST------------KRLHRRAIKQGMTSSPTSSVTRIRAGNCGWHWFSMAVMLVLLC--------------LNGVS------AMW---W----------SPGSDSKLI------------------------------DTRRLC--QW----A-RRNGG------E-AARMC------RKESNTI-N-EIRHGIDRGLRSCSEDLRHDRWNCSQA-------------------------------------KKVYFG--N--VM--R--------------------------KD-LRETAYVQALTAAAVTYQITLACTK-GRL--NC-G-C-SEIA--RQQRRSILLM-----EAEKRRRTVDVDSLD-ELV---------------------------------------------EE--------F-------EWGAC-GD-NIEFGSLKAMEFMD-IQRR---------------------------------------------KVE---AAKGNITEAVYVHNFEAG-QM----TIV--DNMRNKCQCHGLSGS-----CTLWTCWPIMPRFVEVRQRIRHKYDYAIRVQASADGTSLVPR--------MRS-RPRF-----PRHS-----LATNRIQGFG------------------------------FNQARHRATNKLVRGNR----VRTVERKRRAARVIRPN-D-LIF-LQSSP-RFCAPNKSK-GSLG----TLGRRCDP-T------------------------------LT-GLGS-CSYLC--CGRGYREEVHTFTE-KCNC-QFV------YCC--ELKCDD-CVRHEKRYYCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT7a --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN-----RKARRCLG-----------------------------------------------------------------HLFLSLGMV---------YL---RI-----------------------GGFSSVVA-LG------------------------------ASIIC--NK----I-PGLAP------R-QRAIC------QSRPDAI-I-VIGEGSQMGLDECQFQFRNGRWNCSAL------------------------------G----ERT--VFG--K--EL--K--------------------------VG-SREAAFTYAIIAAGVAHAITAACTQ-GNL-SDC-G-C-DKEKQGQYHRD--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DIRYGIGFAKVFVD-AR-------------------------------------------------E----IKQNARTLMNLHNNEAG-RK----ILE--ENMKLECKCHGVSGS-----CTTKTCWTTLPQFRELGYVLKDKYNE-AVHV-EPVR-AS-RNKR----PTFLK-IKKPL---------------------------------------------------------------------------------SY-RKP-MDT-D-LVY-IEKSP-NYCEEDPVT-GSVG----TQGRACNK-T-------------------------------A-PQASGCDLMC--CGRGYNTHQYARVW-QCNC-KFH------WCC--YVKCN-TCSERTEMYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt7a.a --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-----RKTRRWIF-----------------------------------------------------------------HIFLCLGII---------YL---KI-----------------------GGFSSVVA-LG------------------------------ASIIC--NK----I-PGLAP------R-QRTIC------QSRPDAI-I-VIGEGAQMGINECQFQFKNGRWNCSAL------------------------------G----ERT--VFG--K--EL--K--------------------------VG-SKEAAFTYAIIAAGVAHAITAACTQ-GTL-SGC-G-C-DKEKQGFYNQE--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DIRYGLSFSKVFLD-AR-------------------------------------------------E----IKQNARTLMNLHNNEVG-RK----ILE--KNMRLECKCHGVSGS-----CTTKTCWTTLPKFRQLGYILKERYNH-AVHV-EPVR-AS-RNKR----PAFLK-VKKPY---------------------------------------------------------------------------------SY-RKP-MDT-D-LVY-IEKSP-NYCEADPVT-GSMG----TQGRICNK-T-------------------------------A-QHTNGCDLMC--CGRGYNTHQYSRVW-QCNC-KFL------WCC--YVKCN-TCSERTEVYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt7a_like --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-----RKTRRWMF-----------------------------------------------------------------HIFLCLGII---------YL---KM-----------------------GGFSTVLA-LG------------------------------ASIIC--NK----I-PGLAP------R-QRIIC------QSRPDAI-I-VIGEGAQMGINECQFQFKHGRWNCSAL------------------------------G----ERT--VFG--K--EL--K--------------------------VG-SKEAAFMYAIIAAGVAHAITSACTR-GNL-SEC-S-C-DKDKQGFYAHD--------------------------------------------------------------------------NG--------W-------KWGGC-SA-DVRYGLGFSKVFMD-AK-------------------------------------------------E----IKHSARTLMNLHNNEVG-RK----VLE--RNMRLECKCHGVSGS-----CATRTCWTTLPKFRELGYILKDKYTS-AIHV-EPVK-AT-RHKR----PTFLK-IKKPY---------------------------------------------------------------------------------SY-RKP-MDT-D-LVY-IEKSP-NYCEADLRS-GSIG----TQGRVCNK-T------------------------------LM-HHPNGCDLMC--CGRGYNTHQYSRVW-QCNC-KFF------WCC--YVKCN-TCSERTEVYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT7b --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MH-----RNFRKWIF-----------------------------------------------------------------YVFLCFGVL---------YV---KL-----------------------GALSSVVA-LG------------------------------ANIIC--NK----I-PGLAP------R-QRAIC------QSRPDAI-I-VIGEGAQMGINECQYQFRFGRWNCSAL------------------------------G----EKT--VFG--Q--EL--R--------------------------VG-SREAAFTYAITAAGVAHAVTAACSQ-GNL-SNC-G-C-DREKQGYYNQA--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DVRYGIDFSRRFVD-AR-------------------------------------------------E----IKKNARRLMNLHNNEAG-RK----VLE--DRMQLECKCHGVSGS-----CTTKTCWTTLPKFREVGHLLKEKYNA-AVQV-EVVR-AS-RLRQ----PTFLR-IKQLR---------------------------------------------------------------------------------SY-QKP-MET-D-LVY-IEKSP-NYCEEDAAT-GSVG----TQGRLCNR-T------------------------------S--PGADGCDTMC--CGRGYNTHQYTKVW-QCNC-KFH------WCC--FVKCN-TCSERTEVFTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt7b.a --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR----SISSCGALL-----------------------------------------------------------------SVYYPQIFL---------ILTSGSY-----------------------LALSSVVA-LG------------------------------ANIIC--NK----I-PGLAP------R-QRAIC------QSRPDAI-I-IIGEGAQLGINECQYQFRYGRWNCSAL------------------------------G----ERT--VFG--Q--EL--R--------------------------VG-SKEAAFTYAITAAGVAHAVTAACSQ-GNL-SHC-G-C-DREKQGYHDQE--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DVKYGVEFSRRFVD-AR-------------------------------------------------E----IKKNARRLMNLHNNEAG-RK----VLE--ERMKLECKCHGVSGS-----CTTKTCWTTLPKFREIGYVLKERYTT-ALEV-EAVR-AT-RFRQ----PSFLR-LKQSR---------------------------------------------------------------------------------GY-IKP-TDT-D-LVF-LERSP-NYCEEDTVT-GSAG----TRGRLCNH-T------------------------------S--PLTDGCNLMC--CGRGHNTHQYTRVW-QCNC-KFQ------WCC--FVKCN-TCSEKTEVFTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt7b.b --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI----LFSSRSVLL-----------------------------------------------------------------SVYYPQIFL---------ILTSGSY-----------------------LALSSVVA-LG------------------------------ANIIC--NK----I-PGLAP------R-QRAIC------QSRPDAI-I-VIGEGAQLGINECQYQFRYGRWNCSAL------------------------------G----ERT--VFG--Q--EL--R--------------------------VG-SREAAFTYAITAAGVAHAVTAACSQ-GNM-SHC-G-C-DREKQGYYNQE--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DIKYGIEFSRKFVD-AR-------------------------------------------------E----IKKNARRLMNLHNNEAG-RK----VLE--ERMKLECKCHGVSGS-----CTTKTCWTTLPKFREIGYVLKDKYNK-AVQV-EVVR-AS-RLRQ----PTFLK-VKRTR----------------------------------------------------------------------------------H-QKP-LET-D-LVY-IERSP-NYCEEDAKT-GSVG----TQGRLCNR-T------------------------------S--PHTDGCDLMC--CGRGYNTHQYTKVW-QCNC-KFQ------WCC--FVKCN-TCSERTEVFTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MW-----PQDYNRYL-----------------------------------------------------------------GAVLCVAIL---------QLG----------------------------SLSTVVA-LG------------------------------ANIIC--NR----I-PGLVP------R-QRAIC------QTRPDLI-V-AIGEGAQRGIDECRYQFRHSRWNCTGM------------------------------D----NDN--VFG--R--EL--R--------------------------IG-SKEAAFTYAISSAALVHAIVTACSQ-GNI-SDC-G-C-DRTKEGDLN-D--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DVKYGLRFCKKFVD-AR-------------------------------------------------E----VEQNARALMNLHNNEAG-RK----VID--QHTRLECKCHGVSGS-----CTMKTCWITLPRFREVGNILKEKYHHDAQLV-EAVR-AR-RTRR----PTFLK-LKNSR---------------------------------------------------------------------------------TF-EKP-REI-S-LVY-LRGSP-NYCERDEAT-GSLG----THGRRCNR-T------------------------------S--PYQDGCDLMC--CGRGYNTHQFVKTW-QCNC-KFH------WCC--YVKCN-QCSERTEEYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MW-----PQDYNRYL-----------------------------------------------------------------GAVLCVVIL---------QLG----------------------------SLSTVVA-LG------------------------------ANIIC--NR----I-PGLVP------R-QRAIC------QTRPDLI-V-AIGEGAQMGIDECRYQFRHSRWNCTGM------------------------------D----NDN--VFG--R--EL--R--------------------------IG-SKEAAFTYAISSAALVHAIVTACSQ-GNI-SDC-G-C-DRTKEGDLN-D--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DVKYGLRFCKKFVD-AR-------------------------------------------------E----VEQNARALMNLHNNEAG-RK----VID--QHTRLECKCHGVSGS-----CTMKTCWITLPRFREVGNILKEKYHHDSQLV-EAVR-AR-RTRR----PTFLK-LKNSR---------------------------------------------------------------------------------TF-EKP-REI-S-LVY-LRGSP-NYCERDEAT-GSLG----TNGRRCNR-T------------------------------S--PYQDGCDLMC--CGRGYNTHQFVKTW-QCNC-KFH------WCC--YVKCN-QCSERTEEYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT---MPKSPRKRLF-----------------------------------------------------------------HLLYLVSTL---------AAG-TGD-----------------------QSLSTVVA-LG------------------------------ANIIC--NR----I-PGLVP------R-QRAIC------QTRPDLI-V-AIGEGAQMGIDECRYQFRHSRWNCTGM------------------------------D----NDN--VFG--R--EL--R--------------------------IG-SKEAAFTYAISSAALVHAIVTACSQ-GNI-SDC-G-C-DRTKEGDLN-D--------------------------------------------------------------------------EG--------W-------KWGGC-SA-DVKYGLRFCQKFVD-AR-------------------------------------------------E----VEQNARALMNLHNNEAG-RK----VID--QHTRLECKCHGVSGS-----CTMKTCWITLPRFREVGNILKEKYHHDAQLV-EAVR-AR-RTRR----PTFLK-LKNSR---------------------------------------------------------------------------------TF-EKP-REI-S-LVY-LRGSP-NYCERDEET-GSLG----THGRRCNR-T------------------------------S--PYQDGCDLMC--CGRGYNTHQFVKTW-QCNC-KFH------WCC--YVKCN-QCSERTEEYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML----FSLPCWILL-----------------------------------------------------------------HLFLVSEWI---------LVGRANI-----------------------FALSSVVA-LG------------------------------ANIIC--NK----I-PGLSP------R-QRSIC------QTRPDAI-I-AIGEGAQKGQEECRWQFRNSRWNCTMP------------------------------D----NTNTGMFG--H--TL--P--------------------------EG-NKEASFVYAINSAGVAHAITQACSQ-GNL-TNC-S-C-DKTKENGYT-E--------------------------------------------------------------------------DG--------W-------KWGGC-SA-DVDYGIRFSRVFVD-AQ-------------------------------------------------E----TEKNARVLTNLHNNEVG-RL----LLS--ECMDLECKCHGVSGS-----CTMKTCWTTLPAFRTVGTTLLEKYNK-VRQV-EPVR-AR-RTRR----PAFLK-LKNSK---------------------------------------------------------------------------------DF-RKP-PRK-S-LVY-LHKSP-NYCEYDPKG-GSSG----TVGRRCNR-T------------------------------S--TEIDGCDLMC--CGRGYNTHQYTKTW-QCNC-KFH------WCC--FVNCI-QCSERTEEYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt7 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTVSPT---------VVWAAFS-----------------------MALSSVVA-LG------------------------------ANIIC--NK----I-PGMAP------K-QRAIC------RSRPDAI-V-SIGEGAKLGLTECQYQFRFMRWNCSTL------------------------------DS---NDS--MFG--Y--ES--L--------------------------GG-TKEAAFIYAMTSAGVSYAITQSCGL-GSL-PNC-G-C-DKDKGDGKLAP--------------------------------------------------------------------------QG--------W-------KWGGC-SA-DIKHGLRLARKFMD-AR-------------------------------------------------E----IAQNARSLMNLHNNRAG-RK----AVK--DNMGTDCKCHGVSGS-----CTMKTCWTTLPPFRKIGDSLKKRYKK-SKIV-VPYL-GR-RART----AVTLI-LKRAK---------------------------------------------------------------------------------RPHRKP-RRS-H-LVY-LDKSP-NYCDFDGKT-GSLG----TVGRKCNR-T------------------------------T--KDTDGCDLMC--CGRGYNTHQYTRTW-QCNC-KFH------WCC--YVNCN-KCSERTEEYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------ILRKILPP--------------------------------------------------------------THAVVVYLYF---------FVFFTFH-----------------------RALSSVVA-LSY-----------------------------AHAIC--NR----I-PGLAP------R-QRTIC------LSHPDSM-A-AAGQGAKLAFEECSYQFRLHRWNCTIT------------------------------DNTAGRTS--PLA--A--QH--T--------------------------IA-SKEAAYTSAIRSAGVSYIITQACSQ-GSI-MSC-G-C-DKTKGDTSNAF------------------------------------------------------------------------SSE---------W-------KWGGC-SA-DIKYGLTFSRLFLD-SK-------------------------------------------------E----VKEDERALMNLHNNRAG-RK----AVK--SQMDTQCKCLGVSGA-----CTIKTCWTTLPGFRSIGDHLKQKFTK-AKQV-VPLQ-SS-RTRN----PEFLH-LKRLK---------------------------------------------------------------------------------SLHRKP-RKA-D-LVY-LKRSP-SYCEKDEGI-GSLG----TTGRLCNR-T------------------------------A--NSYNNCDLMC--CGRGYNTHQYTRTW-QCDC-KFH------WCC--HVTCD-ECTELTEEYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTEHMQNSSIIRRLIKSSETENLKTFSLSRATSSICLPIGITTSKIQPFLPIPATRTCRH-CNALNIHRRGKWRLAKLLSFPFVVLICL---------LI-----------------------------VPTSVVAFVG------------------------------ANYIC--NK----I-PGLSP------Q-QRIRC------QSRPDAI-V-AVNEGAHKGLQECQRQFRHHKWNCSTQ------------------------------K----ERS--IFG--D--DQ--K--------------------------LA-TKEAAIHNAIRAAGVLHAIVTACGE-GNL-RDC-G-C-DKSLRGYFPDESKSKW-----------------RRQ-NIMLEMSRRSM-----------------------------------SLQT--------W-------KWGGC-SI-DLKHGIQYSKDFWD-SR-------------------------------------------------E----MRRDARGLMNLHNYEAG-RY----AVE--NNVKLECKCHGVSAS-----CTTKTCWLTLPDFRKVGDTLKKSYER-SRRV-TVQT-G--RIRP----MYLIN-LEKRG---------------------------------------------------------------------------------RS-NKP-RKN-D-LVY-LVPSP-EYCENDIIS-ETQG----TVGRTCNK-T------------------------------S--TGVNSCDNMC--CGRGYRTHHRVHKW-DCKC-KFF------WCC--HVKCK-QCRENVEQYTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTELIQNSSIIRRLIKSSETENLKTFSLSRATSSLCLPIGNTTSKIQPFRPIPATRTCRH-CNALNIHRRGKWRLAKLLSFPFVVLICL---------LI-----------------------------VPTSVVAFVG------------------------------ANYIC--NK----I-PGLSP------Q-QRIRC------QSRPDAI-V-AVNEGAHKGLQECQRQFRHHKWNCSTQ------------------------------K----ERS--IFG--D--DQ--K--------------------------LA-TKEAAIHNAIRAAGVLHAIVTACGE-GNL-RDC-G-C-DKSLRGYFPDESKSKW-----------------RRQ-NIMLEMSRRSM-----------------------------------SLQT--------W-------KWGGC-SI-DLKHGIQYSKDFWD-SR-------------------------------------------------E----MRRDARGLMNLHNYEAG-RY----AVE--NNVKLECKCHGVSAS-----CTTKTCWLTLPDFRKVGDTLKKSYER-SRRV-TVQT-G--RIRP----MYLIN-LEKRG---------------------------------------------------------------------------------RS-NKP-RKH-D-LVY-LVPSP-EYCENDVIS-ETQG----TVGRTCNK-T------------------------------S--TGVNSCDNMC--CGRGYRTHHRVHKW-DCKC-KFF------WCC--HVKCK-QCRENVEQYTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQ-----TVAQRNFT-----------------------------------------TCRY----------------KIIIN-FDSNFKK---------LLKHSRM-----------------------ARDISGRN-NE------------------------------RNPSC--DR----M-PDLSS------V-QRQLC------YSQPSVL-V-AISRGLTLGDKECRRQFRNHRWNCTAV------------------------------G----KIS--MLG--P--RL--K--------------------------IG-VKEAAYESAIKSATVLYSLMTACSA-NKL-KGC-G-C-NKEVFVSPKRRRYIQHK----------------IRN-PSDVA-----------------------------------------LVKG--------W-------TWGGC-GS-DIKQAVEYSRKFLQ-ST-------------------------------------------------E----AMRQPRSLMDDHNNEVG-RK----VVT--NYLRAKCKCHGASGS-----CTTRTCWVIMPALKEVGNVLKRKYNR-AQKV-KAMMHG-GR-------AIYIH-VANTP---------------------------------------------------------------------------------KF-VKA-KRK-Y-LVY-LDDSP-DYCAEDLTA-GVAG----TKSRQCNA-T------------------------------S--KHNDNCDDLC--CGRGYSEQTYKRTW-HCDC-QFK------WCC--KVNCN-VCQESRGKHVCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQ-----TVAQRNFT----------------------------------------------------------------SE-FARFFGF---------LLVISAM-----------------------ARDISGRN-NE------------------------------RNPSC--DR----M-PDLSS------V-QRQMC------YSQPSVL-V-AISRGLTLGDKECRRQFRNHRWNCTAV------------------------------G----KIS--MLG--P--RL--K--------------------------IG-TKEAAYESAIKSATVLYSLMTACSA-NKL-KGC-G-C-NKEVYVSPKRRRYIQHK----------------MRN-PSDVA-----------------------------------------LVKG--------W-------TWGGC-GS-DIKQAVEYSRKFLQ-ST-------------------------------------------------E----AMRQPRSFMDDHNNEVG-RK----VVT--NYLRAKCKCHGASGS-----CTTRTCWVIMPALKEVGSVLKRKYNR-AQKV-NAMMHG-GR-------AIYLH-VANTP---------------------------------------------------------------------------------KF-VKP-KRK-Y-LVY-LDNSP-DYCTEDPNA-GVTG----TKSRQCNA-T------------------------------S--KHTDNCDDLC--CGRGYTEQTYKRTW-HCEC-QFK------WCC--KVNCN-VCQENRGKHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt7 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VR------------------------------VNPIC--RS----V-PGLLP------D-QRKMC------VSHPDLL-G-VISAGILNGAEECRRQFRHHRWNCTAL------------------------------G----DHT--LFK--P--EL--K--------------------------IG-TREAAYQSAIKSAAVLQSIVTSCAE-NKL-SEC-G-C-DTSRYGEFAASRWRRN-----------------ANR-PSQVN-----------------------------------------RAQV--------W-------MWGGC-SA-ELGYAMEYSRKFLA-AG-------------------------------------------------E----QKYTERALMNLHNYETG-RR----VVS--NYLRARCKCHGASGS-----CTTRTCWVVLPQLREVSSILKKKHTR-ANKV-SVIYYD-QK-------ATFLY-LTNKK---------------------------------------------------------------------------------KY-AKP-KKN-S-LVY-LDESP-SFCDEDEIV-GSTG----TTSRKCNA-T------------------------------S--TKQDNCNTLC--CGRGFSVQSFTRQW-QCDC-EFS------WCC--RVKCR-ICQESSGRHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MY-----NWS---------------------------------------------------------------------SLNFVFSTLL---------LFVSSSP-----------------------AALTSVSS-IR------------------------------AGVFC--DK----I-IGLAP------L-QRAKC------RARPDAM-T-VIAQGAERARYECIWQFRYDKWNCTNN------------------------------G----TAT--VFG--T--EL--S--------------------------VA-SRESAFENAIKSAGILYEIVKACGE-GNLGASC-G-C-AKHDISFQ--RTKRRT-----------------QMT-PAQVE--RK-------------------------------------VYQR--------W-------RWGGC-SV-DLGFGLNYTREFMR-AG-------------------------------------------------E----LLQSSRTLMNRHNYEAG-RL----AII--KNLTKSCRCHGVSGS-----CNVKTCWIALPSFRQVGDNLRRKYKE-AKRV-EAIL-G-GRRRR----PHILK-IWR-----------------------------------------------------------------------------------NP-KKP-SPR-E-LVY-LEKSP-EFCQKDNRI-GIFG----TQGRQCNG-T------------------------------N--SNYSGCGKLC--CNRGYRVTEYIKID-QCKC-KFF------WCC--TVTCQ-ECPRLVSKYTCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FR-------------------------------------------TLSSVAS-LR------------------------------PGLLC--NK----I-DGLAP------S-QRRMC------QARPDLM-P-LIAKGVHRAWYECQWQFRNNKWNCTHN------------------------------G----TNS--APNHWK--KF--E--------------------------ES-TKESAFEYAIKSAGILYEIVKACGE-GRLGASC-G-C-AKHDVSFQ--RSKRRT-----------------QVS-PSQVD--RG-------------------------------------MYQR--------W-------RWGGC-SV-DLGFGLNYTREFVD-GR-------------------------------------------------E----IQRTTRSLMNRHNLEAG-RL----AIT--KNLTKSCRCHGVSGS-----CNVRTCWIALPSFRQVGNNLRQKFVS-ARRV-DAIL-G-GKRRR----PHILK-IRN-----------------------------------------------------------------------------------KA-RKP-SPR-E-LVF-LDTSP-EFCERDRRT-GIFG----TSGRQCNG-S------------------------------A--QNYSGCDSLC--CNRGYRTAEYDKQE-PCRC-KFF------WCC--TVTCQ-KCIRKVKTYTCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-----SRP------------------------------------------------------------------PTQINLTSFLVKL---------TNII-YC-----------------------RVLSSVVA-QG------------------------------SYEIC--NN----I-KGMTP------P-QISMC------EARPNAI-I-TVSQGMNMASKECKHQFRDSRWNCTAK------------------------------G----NAS--MYG--P--EL--R--------------------------IG-TKEAAFDGAIKSAGVLHAIVTACGK-GSI-NGC-G-C-DSKKGSLRYRRTPK-------------------RRS-PHQVQ---R-------------------------------------EFRV--------W-------RWGGC-SA-DMSFGNNYSTAFVD-AR-------------------------------------------------E----IRKTDRSLMNLHNYEVG-RR----VVS--NNLKRKCRCHGVSGS-----CTMSTCWntLPTFREVGNILRQKYKY-AKKV-SIYRDP--SRKR----ALSLM-LKQPRGTK----------------------------------------------------------------------------VIHP-RKP-SYR-D-LVF-LRNSP-SFCENNNRV-GSFG----THGRQCDR-D------------------------------P--ESKSNCDYLC--CKRGYRTIDYTTEE-ACEC-RFY------WCC--TVYCASTCVTAQKNYTCY---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt7 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQINLHSKLKKI---------NLRI-YC-----------------------RVLSSVAA-QG------------------------------SYEIC--NN----I-KGMTP------P-QISMC------EARPNTI-I-AVSQGMNMASRECKYQFRDSRWNCTAK------------------------------G----NAS--MYG--P--EL--R--------------------------IG-TKEAAFDGAIKSAGVLHAIVTACGK-GSI-NGC-G-C-DSKKSSLRYRRTPK-------------------RRS-PHQVQ---R-------------------------------------KIRV--------W-------RWGGC-SA-DMSFGNNFSTAFVD-AR-------------------------------------------------E----IRKTDRSLMNLHNYEVG-RR----VVS--NNLKRKCRCHGVSGS-----CTMSTCWntLPTFREVGNILRLKFKY-AKKV-SIYRDP--SRKR----ALSLM-LKQPRGTI----------------------------------------------------------------------------VTHP-RKP-LYR-D-LVY-LRNSP-LFCENNNRV-GSFG----THGRQCDR-D------------------------------P--KSPRNCNYLC--CKRGYRTINYTVEE-ACDC-RFF------WCC--TVSCASTCVKSLKKYTCY---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-----SICSRTKTGA-------------------------------FQVLPGCELMLHFCN----------RSQKTKDTLFAVIVII---------LLIQSF-------------------------TISTRAAMPG------------------------------SRYIC--DK----I-PGLTP------R-QRSIC------HRNPSAT-I-LADEGSFMGLEECQRQFKHSRWNCSSN------------------------------E----DAS--AMT--S--DE--R--------------------------IG-TKEAAFHSAVRAAGVLHAIAKACTQ-GQV-RNC-G-C-DSSKRDYFTRADYRKW-----------------RVD-KTDNR--DN-------------------------------------RPSL--------W-------EWGGC-SV-SIRQANRLCREVWD-SR-------------------------------------------------E----MSRNLRARINLHNYVAG-RK----ALM--KKLRIRCKCHGKSAS-----CTLKTCWVTLPDFREVGNALRVAYAK-STKVRSI--SGR-RSRNQY--PIIGY-YKNGI----------------------------------------------------------------------------------P-TKP-LKR-D-LVY-TDDSP-SYCVFNETT-RTAG----TEGRVCWM-T------------------------------S--DR-DYCSHLC--CGRGHKPERIERKW-DCKC-KFY------WCC--RVECD-ECSEKAEQYTCH---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt7 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISFSVQN---------ALETGSK-----------------------KLFVDSVA-IP------------------------------PSIIC--TR----I-QPLSA------K-QMRFC------EDKPGTM-V-SISQGYDLGVEECKYQFRNKRWNCSLL------------------------------G----EER--PFG--Q--RA--V--------------------------PG-TKEAAFTHAIISAGIVQAVTLACTQ-NP--TGC-G-C-DRNKDGIS----------------------------------------------------------------------------REG--------W-------KWGGC-SV-NIGHGLAVAKEFLN-AN-------------------------------------------------D----AVRSDIALMNRHNNEVG-RE----VVN--RSLLTECTCHGPSAS-----CVTRTCSQALPSPRAVSNRLKALYDT-ARRA-TVYLSS--------------L-VRPDD---------------------------------------------------------------------------------KV-EKV-KPM-D-LAY-LKDSP-NYCTKNTLS-KLPG----TLGGNCKI-SDD----------------------------S--QEEENCDVMC--CGRGYDTHLITKRW-QCRC-KFV------WCC--NVRCS-TCSKRDIVQTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt7b --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-----KWCFATFI---------------------------------------------------------------RLTLISFSVQN---------ALETGSK-----------------------KLFVDSVA-IP------------------------------PSIIC--TR----I-QPLSA------K-QMRFC------EDKPGTM-V-SISQGYDLGVEECKYQFRNKRWNCSLL------------------------------G----EER--PFG--Q--RA--V--------------------------PG-TKEAAFTHAIISAGIVQAVTLACTQ-NP--TGC-G-C-DRNKDGIS----------------------------------------------------------------------------REG--------W-------KWGGC-SV-NIGHGLAVAKEFLN-AN-------------------------------------------------D----AVRSDIALMNRHNNEVG-RE----VIR--NNLDLSCKCHGPSGS-----CNTKTCWKSVPSFRMVGEKLRALYE--SRQA-TVKVVAAMKTSKGGQVPAYIV-VKGTN---------------------------------------------------------------------------------KV-VKPNSSA-N-LVY-LDNSP-SYCNKIKSL-KVPG----TVGRVCSR-TPE----------------------------S--AEDVSCEVMC--CGRGYSVREQIKEW-KCHC-KFH------WCC--RVECA-KCSKKLMVHTCQ---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt8_like ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---AYFCRWA-----------------------------------------FLFPIWDKAILGH----------------------------TWTM---NN----L-LITGP------K------------AYLT--Y-ANSVRVGAQSGIHECKHQFAWDRWNCPD-------------------------------T----ALQLSTH---K--GL----------------------------RSA-TRESSFVHAISAAGVMYTLTRNCSL-GD-LNEC-G-C-DSSR-----------------------------NGR-LGG---------------------------------------------RG--------W-------LWGGC-SD-NVDFGERISKQFVD-AL-------------------------------------------------E----TGQDARAAVNLHNNEAG-RL----AVK--ATMKRICRCHGMSES-----CTMQTCWMQLADFREIGNYLKVKHDQAQKLEMDKRRMR-----------AGNS-ADNRVTMT-------------------------------------------------------------------------------DAFGSIART-E-LIY-LEDSP-DYCAKNLSL-GLPG----TEGRECVQ---------------------------HGESLS-QWERRSCRRLCHECGLRVEERRTEVVS-SCNC-KFH------WCC--TVKCEN-CSQVTVKHVCTRRH-GS-HGHNRRRP-----RGPK---------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt8a ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---NPCQIFA----------------------------------------SLVMSICCHILSST----------------------------AWSV---NN----F-LMTGP------K------------AYLA--Y-TSSVQAGAQSGIEECKHQFAWDRWNCPE-------------------------------S----ALQLSTH---K--GL----------------------------RSA-TRETAFVHAISAAGVMYTLTKNCSM-GD-FENC-G-C-DDSK-----------------------------IGK-MGG---------------------------------------------RG--------W-------VWGGC-SD-NVNFGDRIAKLFVD-AL-------------------------------------------------E----NGHDSRAAVNLHNNEAG-RL----AVK--ATLKRTCKCHGLSGS-----CSIQTCWMQLADFRDIGSYLKIKHDQARKLEMDKIRMR-----------AGNS-ADNRGAIA-------------------------------------------------------------------------------DTFSSVART-E-LIF-MEDSP-DYCVKNLSM-GLHG----TEGRECLQ---------------------------SGKNLS-QWERRSCRRLCHECGLKVEERRIETVS-SCNC-KFH------WCC--TVKCET-CTQTVTRYFCAKRH-RNRRPHNHSRKRRHTRRG------------------------------------------------------------------------------------------------------------------------------------------ Hsa_WNT8a ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG--NLFMLWA------------------------------------------ALGICCAAFSAS----------------------------AWSV---NN----F-LITGP------K------------AYLT--Y-TTSVALGAQSGIEECKFQFAWERWNCPE-------------------------------N----ALQLSTH---N--RL----------------------------RSA-TRETSFIHAISSAGVMYIITKNCSM-GD-FENC-G-C-DGSN-----------------------------NGK-TGG---------------------------------------------HG--------W-------IWGGC-SD-NVEFGERISKLFVD-SL-------------------------------------------------E----KGKDARALMNLHNNRAG-RL----AVR--ATMKRTCKCHGISGS-----CSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLR-----------AGNS-AEGHWVPA-------------------------------------------------------------------------------EAFLPSAEA-E-LIF-LEESP-DYCTCNSSL-GIYG----TEGRECLQ---------------------------NSHNTS-RWERRSCGRLCTECGLQVEERKTEVIS-SCNC-KFQ------WCC--TVKCDQ-CRHVVSKYYCARSP-GSAQSLG---------KGSA---------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt8b ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFMHLEVYYYA-------------------------------------------FILMAHMKTCC----------------------------GWSV---NN----F-LMTGP------K------------AYLI--Y-SSSVAAGAQSGIEECKYQFAWDRWKCPE-------------------------------R----ALQLSTH---S--GL----------------------------RSA-NRETAFFHAISSAGVMYTLTRNCSL-GD-FDNC-G-C-DDTR-----------------------------NGQ-RGG---------------------------------------------QG--------W-------LWGGC-SD-NVGFGEVISKQFVD-AL-------------------------------------------------E----TGQDARAAMNLHNNEVG-RK----AVK--GTMQRTCKCHGVSGS-----CTTQTCWLQLPEFREVGNYLKEKYHRAVKVDLLRG--------------AGNS-AASRGAIA-------------------------------------------------------------------------------ETFNSISRK-E-LVH-LEDSP-DYCLENRTL-GLPG----TEGRECLR---------------------------KGKNLS-KWEKRTCKRLCGDCGLAVEERRAETVS-SCNC-KFH------WCC--AVKCEQ-CRKTVTKYYCVKRS-KRVKNDNASRRKSYRLKKKH---------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT8b ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFL-SKPSVYI-------------------------------------------CLFTCVLQLSH----------------------------SWSV---NN----F-LMTGP------K------------AYLI--Y-SSSVAAGAQSGIEECKYQFAWDRWNCPE-------------------------------R----ALQLSSH---G--GL----------------------------RSA-NRETAFVHAISSAGVMYTLTRNCSL-GD-FDNC-G-C-DDSR-----------------------------NGQ-LGG---------------------------------------------QG--------W-------LWGGC-SD-NVGFGEAISKQFVD-AL-------------------------------------------------E----TGQDARAAMNLHNNEAG-RK----AVK--GTMKRTCKCHGVSGS-----CTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQG--------------AGNS-AAGRGAIA-------------------------------------------------------------------------------DTFRSISTR-E-LVH-LEDSP-DYCLENKTL-GLLG----TEGRECLR---------------------------RGRALG-RWERRSCRRLCGDCGLAVEERRAETVS-SCNC-KFH------WCC--AVRCEQ-CRRRVTKYFCSRAE--RPRGGAAHKPG----RKP----------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt8 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------YS-I---------V-------------------------LSCILGFLILESQHGVQ----------------------------SWSL---NN----F-LMTGP------K------------AYLT--F-SQSVAAGAMHGMEECRHQFLWDRWNCPE-------------------------------S----SLPMFTQ---N--AL----------------------------ERA-NRETSFVHAISSAGVMYTLTRNCSL-GD-FDKC-G-C-DDTK-----------------------------KGD-QGG---------------------------------------------EG--------W-------KWGGC-SD-NVNFGERVSKMFVD-AL-------------------------------------------------V----TGKDAWAVMNLHNNEAG-RK----AVR--QTLKRTCKCHGVSGS-----CTTQTCWKQLSEFRVIGDFLKRKYGNGLLVDYVRGGLE-----------KANS-ASEQ------------------------------------------------------------------------------------ALSPLSKK-D-LVY-LEASP-DYCRVNVSA-GSMG----TVGRECVR-GT----------------------KKSKDEQG-KWEKQSCKRLCSTCGLKVKKTKVIEKS-SCNC-KFH------WCC--SVKCDE-CQQEVTKLTCQT--------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt8 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFA--------QL---------L-------------------------WSLSVLLAALSGTADSN----------------------------GWTLQ--SN----F-LITGP------K--SSFQ------ASLT--Y-ASSVAAGAQTAMEECKHQFSWDRWNCTD-------------------------------N----ALSMFKP---N--TL-----------------------------PA-NREASFVHAISAAGVMYVLTRNCSK-GA-FEQC-G-C-DLTN-----------------------------NGK-KAE---------------------------------------------GG--------W-------TWGGC-SD-DIAFGERISKMYSD-GV-------------------------------------------------E----NGQDARAAMNLHNNDVG-RK----AVR--QTMKRVCKCHGVSGS-----CTTKTCWLQLADFRAIGVFLKKKYKKADKVDYVRGQLT-----------ENNS-ASSKR-------------------------------------------------------------------------------------NTGLKK-D-MVF-LEDSP-DYCRENLTV-GSRG----TLGRECLR-G-------------------------GGKNMD-KYEKKSCKRLCKDCGYVPKRITTEVTS-SCNC-KFH------WCC--SVKCSQ-CTKTVTKYICVQRESSKNRRKNVRKKSKQRRRNR--GNN------------------------------------------------------------------------------------------------------------------------------------ Bla_Wnt8 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLFA--------RV---------L-------------------------WSMSVLFAVLSRTVESN----------------------------GWTLQ--SN----F-LIAGP------K--SSFQ------ASLT--Y-ASSVAAGAQTAMEECKYQFSLDRWNCTD-------------------------------N----ALSMLKP---N--TL-----------------------------PA-NRETSFVHAISAAGVMYVLTRNCSK-GA-FEQC-G-C-DQTN-----------------------------NGK-KAE---------------------------------------------GG--------W-------TWGGC-SD-DISFGESISKRYSD-GV-------------------------------------------------E----NGQDARAAMNLHNNDVG-RK----AVR--QTMKRVCKCHGVSGS-----CTTKTCWLQLADFRAIGVFLKKKYKKADKVDYVRGQLT-----------ENNS-ASSKR-------------------------------------------------------------------------------------NTGLKK-D-MVF-LEDSP-DYCRQNLTV-GSRG----TLGRECLR---------------------------GGKNMD-KYEKKSCKRLCKDCGYVPKRITTEVTS-SCNC-KFH------WCC--SVKCSQ-CTKTVTKYICVQRE-SKNRRKNVRKKSKQRRRNNLRGNNN----------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt8 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFT--------RV---------L-------------------------WSMSLLLAVLFRTAESN----------------------------GWTLQ--SN----F-LITGP------K--SSLQ------ASQTYEY-ASSVAAGAQTAMEECKYQFSWDRWNCTD-------------------------------N----ALSMFKP---N--TL-----------------------------PA-NRETSFVHAISAAGVMYVLTRNCSK-GA-FEQC-G-C-DLTN-----------------------------NGK-KAE---------------------------------------------GG--------W-------TWGGC-SD-DIAFGEEISEMYTD-GV-------------------------------------------------E----NGQDARAAMNRHNNDVG-RE----AVR--QTMKRVCKCHGVSGS-----CTTKTCWLQLADFRAIGVFLKKKYKKADKVDYVRGQLT-----------ENNS-ASSKR-------------------------------------------------------------------------------------NPGLKK-D-MVF-LEDSP-DYCRENLTV-GSRG----TLGRECIR---------------------------GGKTTD-KYEKKSCKRLCKDCGYVPKRITTEVTS-SCNC-KFH------WCC--SVKCSQ-CTKTVTKYICVQRE-SKNRRKNVRKKSKQRRRNKI---------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt8 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLCTYYNAS----------------------------AINIR--FH----F-RLSIN------L--SLLQ------SYMA--L-VDSVSSGTQLGLRECQEQFKWERWNCPL-------------------------------K-----QSVLRPF--N--ARV-------------------------QADTV-TKEISFGQAITCAGVAHTITKNCSS-GE-FENC-R-C-DESK-----------------------------KGK-KGG---------------------------------------------RT--------W-------KWGGC-SD-NLRFGERVSKLFFD-DR-------------------------------------------------V----AATDAMATVNLHNNEVG-RT----ALK--KTMELICKCHGVSGS-----CTTKTCWQHLSDFRSVGTFLKRCYARAIDVDFQNGALQ-----------QTAT-RRHRR----------------------------------------------------------------------------------DRSELIRKT-D-LVY-LQTSP-DYCRVN----GSYA----TLGRQCVR-SSAA--------------------AKSGRRNR-HPERKSCHRLCKACGLKVTDKVVEVTS-SCKC-KFK------WCC--EVACQQ-CRRKVELSTCTL--------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt8 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MK------------------------------------------------LQLIINLLVILNSST----------------------------GQKL---TA----K-LILQQ------E------------SLET--L-KNSILYASNSAERECRQQFKASKWNCSSVWA----------------------------R----PIKMRDP---M--YM--------------------------IRRLA-NRETAFVHSINTAAVTYFLTRDCRR-GI-FRNC-A-C-----------------------------------VR-QTG---------------------------------------------QA--------G-------EWRGC-ND-NVKFGEVLSKHFLN-ARH------------------------------------------------V----DKRKARAVIHLHNNAVG-RK----AVK--KTLKQQCKCHGVSGG-----CSSKSCWKTLPLFSEIGDYLKAKYQQAQKVRLHTNKLV-----------LKLP-SRVFA-----------------------------------------------------------------------------------PLTKKARR-S-LVF-LKPSP-DYCHRDTKK-GSTG----VLGRECSS--------------------------------D-SPNYLECIQMCTSCDYRVEKKLAVRSS-KCNC-KFV------WCC--DIKCSE-CKKLVAVTKCVR--------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt9a --------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDGHLLLGWLSFTI-IVHL--ISLPGPST-----------AYFGLTG-----------------------NEPLSILPLTSQP---------------------DERAGKSHYKLC--DR----L-KLE-K------K-QRRMC------RRDPGVA--ETLMEAISMSALECQYQFRFERWNCT-LE-----------------------------G----RYRANILK--R--GF---------------------------------KETAFLYAISSAGLTHAMAKACSA-GR-MERC-T-C-DEA------------------------------PDL-ENR---------------------------------------------KA--------W-------QWGGC-GD-NLKYSNKFVKDFLG----------------------------------------------------K---RSNKDLRARIDMHNSNVG-MK----VIK--TGVETTCKCHGVSGS-----CTVQTCWRQLAPFHEIGKQLKQRYETSVKVA-SSTNEAT---------GEGE--ISQSRSQ---------------------------------------------------------------------------SQQPP-QPDIPRTP-D-LLH-IEDSP-SFCRP--SK-YSAG----TLARKCYK-------------------------------------DKNCEAIC--CGRGHNTQSRVVTR-PCQC-QVR------WCC--YVECKQ-CTQKEEVYTCK----G----------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT9a --------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDGSPLARWLAAAFGLTLL--LAALRPSA-----------AYFGLTG-----------------------SEPLTILPLTLEP----------------------EAAAQAHYKAC--DR----L-KLE-R------K-QRRMC------RRDPGVA--ETLVEAVSMSALECQFQFRFERWNCT-LE-----------------------------G----RYRASLLK--R--GF---------------------------------KETAFLYAISSAGLTHALAKACSA-GR-MERC-T-C-DEA------------------------------PDL-ENR---------------------------------------------EA--------W-------QWGGC-GD-NLKYSSKFVKEFLG----------------------------------------------------R---RSSKDLRARVDFHNNLVG-VK----VIK--AGVETTCKCHGVSGS-----CTVRTCWRQLAPFHEVGKHLKHKYETALKVG-STTNEAA---------GEAGA-ISPPRGR---------------------------------------------------------------------------ASGAGGSDPLPRTP-E-LVH-LDDSP-SFCLA--GR-FSPG----TAGRRCHR-------------------------------------EKNCESIC--CGRGHNTQSRVVTR-PCQC-QVR------WCC--YVECRQ-CTQREEVYTCK----G----------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt9b --------------------------------------------------------------------------------------------------MCTGLP-------------------------------------------RT-----------------------------------------------------------------------------------------------------------------------------------------ACPLRLIAL--CILLSHAA-----------AYFGLTG-----------------------REPLVFLPGPFAN---------------------EPTNGKAHLKQC--EQ----M-TLT-R------R-QKRLC------RREPGLA--ETLRESVRLSLLECRYQFRNERWNCS-MD-----------------------------G----RG--SLLK--R--GF---------------------------------KETAFLLAVSSAALSHALAKACSS-GR-MERC-T-C-DDS------------------------------PGL-QHR---------------------------------------------EA--------W-------QWGVC-GD-NLKYSTKFLKKFLG---------------------------------------------------QK---RVSKDLRAQIDAHNINVG-IR----AVK--SGLKTTCKCHGVSGS-----CAVRTCWKQLSPFQDTGHLLKYRYDTAVRVH-SVTNSAT---------GETEL-AGPRRHSI--------------------------------------------------------------------------------TLPRPRPT-E-LVF-LEESP-SFCRP--SR-YSPG----TAGRPCSK-------------------------------------DTSCSSLC--CGRGYNTALRLTTL-SCHC-QVR------WCC--HVECQT-CLREEEVYTCKKH-------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt9 --------------------------------------------------------------------------------------------------M------------------------------------------------------------------------------------------------RCAVGGQSQIRGTRAR--------------------------------------------------CVITKYVQGRTDKIMSPA-------SCLLGVLLLWDLIPRPDAL-----------SYFGLTG-----------------------REPLMVLPLGV-----------------------DDINALPPVKIC--ES----F-KLK-R------K-QRRMC------KRDAGVA--ETLVEAMHMSARECQHQFHNERWNCT-L------------------------------G----KTRLNMLK--R--GF---------------------------------KETAFLYAISSSGLTHALGRACSS-GK-LERC-T-C-DESF-----------------------------NDI-DNR---------------------------------------------ET--------W-------LWGGC-GD-NLKYSRKFARQFLS-M-------------------------------------------------NK---AEEQDLRAAVDRHNTNLG-IR----VVR--SRVKTTCKCHGVSGS-----CSVQTCWRQLAPFHEIGDVLKNKYEKAMKVV-SMTNGAG---------ERAQL-MNEPVGNE--------------------------------------------------------------------------------APKGPKNN-D-MVF-VDDSP-SYCKK--GK-YSYG----TRGRICDK-------------------------------------EKNCDSIC--CGRGHNTQSLIIKR-PCQC-QVK------WCC--YVECKE-CNTREEIYMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt9 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPA-------SCLLGVLLLWDLMPGPDAL-----------SYFGLTG-----------------------REPLMVLPLGV-----------------------DDINALPPVKIC--ES----F-KLK-R------K-QRRMC------KRDAGVA--ETLVEAMHMSARECQHQFHHERWNCT-L------------------------------G----KTRLNMLK--R--GF---------------------------------KETAFLYAISSSGLTHALGRACSS-GK-LERC-T-C-DESF-----------------------------NDI-DNR---------------------------------------------ET--------W-------LWGGC-GD-NLKYSRKFARQFLS-M-------------------------------------------------NK---AEEQDLRAAVDRHNTNLG-IR----VVR--SRVKTTCKCHGVSGS-----CSVQTCWRQLAPFHEIGDVLKNKYEKAMKVV-SMTNGAG---------ERAQL-MNEPVGNE--------------------------------------------------------------------------------APKGPKNN-D-MVF-VDESP-SYCKK--GK-YSYG----TRGRICDK-------------------------------------EKNCDSIC--CGRGHNTQSLIIKR-PCQC-QVK------WCC--YVECKE-CNTREEIYMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt9 --------------------------------------------------------------------------------------------------MSRMVSL---------------------------TTGLWC---------RSAGWFLLFGVGVGGIKNRP---------------------TGNFQPMGCVXAGPGQIRGTRTR--------------------------------------------------CAITKYVQGWTDKIMSPA-------SCLLGVLLLWDLIPGPDAL-----------SYFGLTG-----------------------REPLMVLPLGV-----------------------DDINALPPVKIC--ES----F-KLK-R------K-QRRMC------KRDAGVA--ETLVEAMHMSARECQHQFHNERWNCT-L------------------------------G----KTRLNMLK--R--GF---------------------------------KETAFLYAISSSGLTHALGRACSS-GK-LERC-T-C-DESF-----------------------------NDI-DNR---------------------------------------------ET--------W-------LWGGC-GD-NLKYSRKFARQFLS-M-------------------------------------------------NK---AEEQDLRAAVDRHNTNLG-IR----VVR--SRVKTTCKCHGVSGS-----CSVQTCWRQLAPFHEIGDVLKNKYEKAMKVV-SMTNGAG---------ERAQL-MNEPVGNE--------------------------------------------------------------------------------APKGPKNN-D-MVF-VDDSP-SYCKK--GK-YSYG----TRGRICDK-------------------------------------EKNCDSIC--CGRGHNTQSLVIKR-PCQC-QVK------WCC--YVECKE-CNTRENIYMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt9 --------------------------------------------------------------------------------------------------MKLSI--------------------------------------------KK----------------------------------------------------------------------------------------------------------------------------------------LICILYLILV----WMSAAT-----------GYFGLTN-----------------------REPLLSLTWGYHNTALE-----------------RNKHKYSSAKLC--EM----L-KLH-R------R-QKRMC------RRGKGIA--ESLLEATRLAVIECQYQFKHERWNCS-L------------------------------G----QYRQNILR--R--GF---------------------------------SETSFLYAISSAGLVHAFARACSK-GV-LDRC-T-C-DES------------------------------KHL-ENH---------------------------------------------KT--------W-------LWGGC-GD-NLRYGLKFTRKFLK-R-------------------------------------------------AR---KSGKDVRAKVNQHNSRVG-IK----VVK--ENVNTTCKCHGVSGS-----CTVKTCWLQLSPFSKIGRTLKNKYERAKKVL-IQTNQAT---------GKNLL-VRRANAE---------------------------------------------------------------------------TNALNNEGRSPKRG-N-LLY-MDESP-SFCRR--SR-YTPG----TTGRTCDK-------------------------------------DRDCETMC--CGRGYNVKHTTVVK-ACKC-QVF------WCC--HVKCKQ-CLKNQEIYMCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt9 --------------------------------------------------------------------------------------------------M------------------------------------------------RG--------------------------------------------------------------------------------------------------------------------------------------------VGIFILIIAATQTGTD-----------SYFGLTE-----------------------KKVHL-----------------------------EQLDAISPN--C--KS----L-SLS-K------K-QRRFC------KKDPG-M-PETLFEAVRLSTAECQYQFFNERWNCT-SG-----------------------------G----GYRENVLK--R--GF---------------------------------KETSFLYAISSAGLAHSVARSCSR-GI-LDRC-T-C-DESF-----------------------------NDQ-TNR---------------------------------------------AT--------W-------KWGGC-GD-NLKYSQKFVQNFLQ-LE------------------------------------------------ST---SRGQDLRAKAEKHNSEVG-VR----LLR--QGFNTTCKCHGVSAS-----CTTRTCWQQLSPFREIGNQLKEKYEKAYKVV-STTNEST---------GTSQL-VTKSQKG-K-SRG---------------------------------------------------------------------ATATDGEEPPPRPS-D-LVY-VDNSP-HFCKK--SR-FSPG----TDGRRCLV-------------------------------------GPNCNSIC--CGRGYNIKTKVVEK-SCKC-RVV------WCC--YVECDM-CSESVEIHLCKNNPDN----------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt9 --------------------------------------------------------------------------------------------------MT-----------------------------------------------RR------------------------------------------------KNPSVESKESEEMP--------------TTSMSSKSEGHIPHMNQQQMTMDAGNSSNIHQD--I-S----SLMNLLGHQMDGKD----------FINVEDHLDPSSFS-----------SSESDVG-----------------------SRVTDMP-EMVPS---------------------GQINKKEARKKC--DD----I-KLT-R------K-QRKFC------RRDPG-M-PQVLDEATKMSVAECQYQFRFERWNCS-T------------------------------G----TTRIHLLT--K--ET---------------------------------RETAFLYAISSAGLTHSVARACAD-GH-LERC-S-C-EETY-----------------------------SDN-LNQ---------------------------------------------EA--------W-------RWGGC-GD-NVRFAAKFVRQFLK---------------------------------------------------SR---TNGKDIRAEVNKHNSDMG-IR----VVK--QSVQQTCKCHGVSGS-----CSTKTCWRKVAPFYDIGKKIKQAYDRASKVG-S-INSAD---------GRPKL-IRLRRSR-R-NR---------------PAKQEKIETTSSI-------SDTALTTTTISTTDPPNTKSPIGIIANPHEV----RSETARWRENPRNS-E-LVY-LENSP-AYCKR--TQ-FSLG----TKGRICDK-------------------------------------EKNCDQIC--CGRGFTTHIRIVRR-SCEC-EVK------WCC--YVKCKT-CTERREIYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt9 --------------------------------------------------------------------------------------------------MT-----------------------------------------------RR------------------------------------------------KNPSVESEESEEMP--------------TISMLSKSDSHIPHINQQQMTMDAGNSSNIHQD--I-S----SLMNLLGNQMDGKD----------FINVEDHLDPSSFS-----------SSESDVG-----------------------SRVTDMP-EMVPS---------------------GQINKKEARKKC--DD----I-KLT-R------K-QRKFC------RRDPG-M-PQVLDEATKMSVAECQYQFRFERWNCS-T------------------------------G----KTRINLLT--K--ET---------------------------------RETAFLYAISSAGLTHSVARACAD-GH-LERC-S-C-EETY-----------------------------SDN-LNQ---------------------------------------------EA--------W-------RWGGC-GD-NVRFAAKFVRQFLK---------------------------------------------------SR---TNGKDIRAEVNKHNSDMG-IR----VTK--QSVQQTCKCHGVSGS-----CSTKTCWRKVAPFYDIGKKIKQAYDRASKVG-S-INSAD---------GRPKL-IRLRRSR-R-NR---------------PAKQEKIDATSSI-------SDTTLTTTTISTTDPPNTKSPMGIIANTHEV----RSETARWRENPRNS-E-LVY-LENSP-AYCKR--TP-FSLG----TKGRICDK-------------------------------------EKNCDQIC--CGRGFTTHIRIVRR-SCEC-EVK------WCC--YVKCKT-CTERREVYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt9 --------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYMTVDSNGQM----------KLNSENIQTQNALSAA-------TNSNASDM------------------------KERETSV-PLVSV---------------------EDINRKQARKQC--DE----L-TLT-R------K-QRRMC------KKDSG-L-PQILREAMVMSVSECQYQFRFERWNCT-I------------------------------G----RTRVHLLS--R--GN---------------------------------KETAFLFAISSAGLAHSVAKGCAK-GY-LELC-S-C-DETY-----------------------------SDY-INQ---------------------------------------------EA--------W-------MWGGC-GD-NVHAAAKFVRKFLR---------------------------------------------------PK---YRSEDIRAEVDKHNSNLG-IR----MVR--RSVFRTCKCHGVSGS-----CTTKTCWKKIAPFYKIGHKLKNAYNKSVRVG-S-VNSAG---------GETKL-VKLKRTR-R-NR---------------PEIATQNT-----------------------RSPPPAAEDQTPERRDGASRNSTILRTRDDFPNNPRNN-E-LVY-LENSP-QYCKR--TR-YSLG----TQGRLCDK-------------------------------------HKNCDRIC--CGRGYTTQVRTVHR-SCEC-EVR------WCC--YVECKT-CVETKEVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt9 --------------------------------------------------------------------------------------------------M-------------------------------------WNKYQRMRN-RRR-----------QNIIYRR-QMIGRRE----------------------SSNDKRSVDGKTRPYGKRHLYGQYRDLSRQQAVNSQSYKFPKEFQENRMGD------HVTDVLIKD----ALKNLHRNDEDGGI----------GTFQTNSPKSPKFPNSHPASGRRTSNHSRDVEFFL-----RETKQLQLNTRIHHNISEQALS-SMKPT---------------------KEINRTESRSKC--EK----M-NLS-R------K-QLKLC------KRDPG-M-PQVLEEATRLAATECQYQFRYERWNCS-L------------------------------G----SSRIFLLN--K--GN---------------------------------RETAFLFAISSAGLTHSVAKACAN-GH-LERC-S-C-EETY-----------------------------SDH-LNQ---------------------------------------------ET--------W-------RWGGC-GD-NVRFASKFVRKFLK---------------------------------------------------SR---GQGQDIRAEVDKHNSNLG-IR----IVK--QSVQQTCKCHGVSGS-----CTTKTCWRKVAPFYTIGRRIKRAYDKAVKVG-S-VNRAN---------GRTKL-VRIRRGI-KHSKR------------NRPNKRGRRMKTDSW-------KHKV----HLEKPHPTKSSPTSSVVTSST------NVESRSQPDKPGTT-E-LVF-LEKSP-KYCSR--SK-YSVG----TKGRVCDK-------------------------------------DKNCDKIC--CNRGYVSETKIVKK-SCEC-EVK------WCC--YVKCKT-CVEERQVYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt9 --------------------------------------------------------------------------------------------------M-------------------------------------WNKYQRLRN--RR-----------QNIIYRR-QMIGRRE----------------------SSNDKRSVDGKTRPYGKRHLYGQYRDLSRQQAVNSQSYKFPKEFQENRMSD------HVTDGLIKD----ALKNLHRNDKDGAI----------GTFQTNSPKSPKFPNSHPPSGRRTSNHSRDVEFFL-----RESKELQINTRRHHNISEQALS-SMKPT---------------------KEINRTESRSKC--EK----M-NLS-R------K-QLKLC------KRDPG-M-PQVLEEATRLAATECQYQFRYERWNCS-L------------------------------G----SSRIFLLN--K--GN---------------------------------RETAFLFAISSAGLTHSVAKACAN-GH-LERC-S-C-EETY-----------------------------SDR-LNQ---------------------------------------------ET--------W-------RWGGC-GD-NVRFASKFVRKFLK---------------------------------------------------SR---GQGQDIRAEVDKHNSNLG-IR----IVK--QGVQQTCKCHGVSGS-----CTTKTCWRKVAPFYTIGRRIKRSYDKAVKVG-S-VNRAN---------GRTKL-VRIRHGT-KHSKR------------NRPSKRPRRTNTDTW-------KHKV----QLEKPHPTKSSPTSSMVTSSA------NIASGSQADKPGTT-E-MVF-LEKSP-KYCSR--SK-YSVG----TKGRVCDK-------------------------------------DKNCDKIC--CNRGYVSETKIVKK-SCEC-EVK------WCC--YVKCKT-CVEERQVYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt9 --------------------------------------------------------------------------------------------------MQGQTG-------------------------------------------RRY---------PPGIAYRR-QLSSS------------------------SSNDKRSVDGK--PYGKRHLYGQYRDLFRQQAINSQ---LYQRNGQGRNQNNKNGEGHVTDKVITS----ALLNLHHAENDD------------SLDIERSPKWSESPSAESP------NHSRDVGFFLRN---RDKSSRKISTVKNSVSNSTDLGPTMHQT---------------------KEINRTEARAKC--EN----M-NLS-R------K-QLKMC------KRDSG-M-PQVLEEATRMAASECQYQFRYERWNCS-L------------------------------G----SSRIFLLN--K--GT---------------------------------RETAFLFAISSAGLTHSVARACAN-GH-LERC-S-C-EETY-----------------------------SDH-LNQ---------------------------------------------EA--------W-------RWGGC-GD-NVRFATKFVRQFLK---------------------------------------------------SR---GQGRDIRAEVDKHNSDLG-IR----MVK--QSVEQTCKCHGVSGS-----CTTKTCWRKVAPFYEIGRKIKKAYDKAVKVG-S-VNRAN---------GRTKL-IRLRRGTNKHRF-STSTASKSPSKIHKLNSDSHRTMGLNL-------NHEVSNEKRLSSTKPTAVSSVSAHTKFTSNALDINSVGRKHNSLKPKHT-E-LVF-LEKSP-KYCTK--SK-YSEG----TKGRICDK-------------------------------------SKNCDKIC--CNRGYTVQTKIVKK-SCEC-EIK------WCC--YVKCKT-CIEEREVYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt9 --------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------SGDLGRVRSERESGKKRDLNKAHLN---SYIVSTS---FTNAQIPSRVAQFDDARQYVADQSLLSANRTSENATSRFTTNSEP----------FLGLDED----SFA-----------SYTAFMK-----------------------SKFGNFT-PLVEP---------------------RNIDRRAARRMC--NN----F-ALT-A------S-QLKKC------RRDPG-M-PQVLSEATHIAAAECQYQFRYEKWNCS-L------------------------------G----SSRIKMLD--K--GT---------------------------------KETAFLYSISSAGLTHTVARACAN-GY-LTRC-S-C-EANY-----------------------------PGV-PKN---------------------------------------------QA--------W-------MWGGC-GD-NVRYAARFVRKFLR---------------------------------------------------SR---HRNKDVRARVNQHNSDVG-IR----IVK--SNVGQACKCHGVSGS-----CTTETCWRKMVPFDVIGKKVKRAYDKAVKVG-G-VNNAN---------GVPNL-IRRGRAPNKR-----------------LAVTTQLQLQRVR-------QHNANVNNRPNHTPPPQENP---------------KQRKNALIGNPKNK-E-MVF-LESSP-SYCSK--TK-YSLG----TKGRICNK-------------------------------------KKDCDRIC--CGRGYTTHVRIIRR-SCNC-QVQ------WCC--YVQCAV-CTDRKVINTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt9 --------------------------------------------------------------------------------------------------M---------------------------------------------------------------------------------------------------TEDLGRVRSERESGKKRDLNKAHLN---SYIVSTS---FANAQIPSRVAQYDDARQYVADQSRPSANRTSTNSTSKLMQYAEP----------FLGLDED----TFA-----------SYTAFMK-----------------------SKFGNFT-PLVEP---------------------RNIDRRAARKMC--NN----F-ALT-A------S-QLKKC------RRDPG-M-PQVLSEATHIAAAECQYQFRYEKWNCS-L------------------------------G----SSRIKMLD--K--GT---------------------------------KETAFLYSISSAGLTHTVARACAN-GY-LTRC-S-C-EANY-----------------------------PGL-PKD---------------------------------------------QA--------W-------MWGGC-GD-NVRYAARFVRKFLR---------------------------------------------------SR---HRSKDVRARVNQHNSDVG-IR----IVK--SNVGQACKCHGVSGS-----CTTETCWRKMVPFDVIGKKVKRAYDKAVKVG-G-VNNAN---------GVPNL-IRRGRAPNKR-----------------LAVTTQLQIQRGQP------RHNANVNNRPNHTPPPQDRP---------------KHRKNALIGNPKNK-E-MVF-LESSP-SYCSK--TK-FSLG----TKGRICNK-------------------------------------KKDCDRIC--CGRGFTTHERIIRR-SCNC-QVQ------WCC--YVQCAV-CTDRKQIHTCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt9 --------------------------------------------------------------------------------------------------MDIQANIPAFSRPNKNNQNPTKPRHDDVTSGPTYITSKFTSSRRPHNYRRR------------NSTSQRVKLNTFSQYQQSARKPEYYIRGLNLSAIV-GNPSVPHVRSERESGKKRDLFGIHRK-PSTYFVSSS---FHQSLPSSSVNMRPMEE-HISE------------RSQTVSNTSRN----------IAEL--S----HIN-----------SYNSFVN-----------------------ERKQRLE-PLAEP---------------------NKINRIQARRMC--DS----F-KLT-T------S-QRRKC------KRDPG-L-PQVLSEATHIAALECQYQFRYERWNCS-L------------------------------G----TTRIHILN--K--GN---------------------------------KETAFLFSISSAGLTHSIARACAK-GH-LRRC-S-C-DDSY-----------------------------IGH-VTD---------------------------------------------QS--------W-------RWGGC-SD-NVHYAAKFVRRFLR---------------------------------------------------SR---STSRDIRAEVDKHNSDLG-IR----VVK--SNLIEKCKCHGVSGS-----CTTKTCWRKVVPFYEISRKIKRAYDKAVKVG-S-INNLN---------GRTRL-IRLRRSRLRQRK-SA-----------RASMTSSTT-------------------QYPNSSAPPDRRNVASNTFKSNVPLSG-RSQSVLKEESPRNK-E-LVY-LENSP-SYCRK--SR-YSEG----TKGRICEN-------------------------------------ERSCHRMC--CGRGYTTHVRVVRS-SCEC-VMK------WCC--VVHCNT-CTERKMIHTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt9 ---------------------------------------------------------------------------------------------------------------------------------------------------RR------------NLTLRR-QSGSGTKHQSYMRRAK--LRGRRFNATFHDTTSVPHVRNERESGRKRDLFGIHRK-HATYFVSSS---YPHSLSPARVSIPASTRYHIPN---IERSRFAPSNSTRVTKDGRT----------VLNLDED----ELD-----------SYYSFVN-----------------------EKRRKSS-PLVEP---------------------EEIDIAAARKMC--DS----F-RLT-T------S-QRRKC------KRDPG-M-PQVLTEATHIAAAECQHQFRDERWNCS-L------------------------------G----TSRIHILN--K--GN---------------------------------RETAFLFSISSAGLTHAVARACAN-GH-LKRC-S-C-DDSY-----------------------------DSH-VTD---------------------------------------------GS--------W-------RWDGC-GD-NVHYAAKFVRRFLK---------------------------------------------------SR---STSRDIRAEVDKHNSDLG-IR----VVK--SNVKVTCKCHGVSGS-----CTTKTCWRKMAPFYEIGRKIKRAYDKAVKVG-S-INNSN---------GRARL-IRLRRSRLRHRKLSG-----------GSSITSSLT------------RHTL----PPVSPTPDSRLNLVANTYRTTTPRATLNPREELKGEIPRNK-E-LVY-LEKSP-TYCRK--SR-YSKG----TKGRVCKD-------------------------------------ERSCDKVC--CGRGYTTHVRLVRR-SCQC-EVK------WCC--AVHCNT-CSERKKIHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt9 --------------------------------------------------------------------------------------------------M--------------------------------------------------------------------------------------------------TSLGIPKMAHKA----------------------------------------------------------------------------------RLTAKEPIVTDVFS-----------EEGNLTW-----------------------DDLPSLM-VTVPP----------------------TMTYNQAQQIC--LR----L-KLH-P------A-QKKMC------LSSLG-I-SSTLLDSVRLSVVECQANFKFDRWNCS-L------------------------------G----KPRINMLN--K--GY---------------------------------KETAYLHALTSSSLVHTFSRACAQ-GR-LDRC-T-C-DESF-----------------------------SAS-KNK---------------------------------------------EA--------W-------LWGGC-GD-NIQYGMKFARRFLR---------------------------------------------------WM---RKSLDLQATADSHNSDVG-IR----VVR--NGINKTCKCHGVSGS-----CTVQTCWRQLANFHEVGSDLKSKYDSAVKVVVS-ANQST---------GKGQL-TKRRKNS---------------------------------------------------------------------------------VQSNPKKG-D-LVF-LEKSP-NYCEP--TA-FGHG----TTGRVCDL-------------------------------------NKNCDILC--CGRGYNIHTRIVDK-PCHC-QVI------WCC--HVKCQR-CSVREDIYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDRAA--------------LLGLA----------------------------RLCALWA--------ALLVLFPYGA----------------------------------------QGNWMWLGIA-----------------SFGV---------PEKLGC--AN----L-P-LNS------R-QKELC------KRKPYLL-P-SIREGARLGIQECGSQFRHERWNCMITAAATTA------------------------P----MGASPLFG--Y--ELS-S---------------------------G-TKETAFIYAVMAAGLVHSVTRSCSA-GN-MTEC-S-C-DT--------------------------------------------------------------------------TLQNGGSASEG--------W-------HWGGC-SD-DVQYGMWFSRKFLD-FPI-GN--------------------------------------------TT---GKENKVLLAMNLHNNEAG-RQ----AVA--KLMSVDCRCHGVSGS-----CAVKTCWKTMSSFEKIGHLLKDKYENSIQI-SDKTKR---------------K-MRRR------------------------------------------------------------------------------EKDQRKIPIH-KD--D-LLY-VNKSP-NYCVEDKKL-GIPG----TQGRECNR-T------------------------------S--EGADGCNLLC--CGRGYNTHVVRHVE-RCEC-KFI------WCC--YVRCRR-CESMTDVHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDNTG---------------CGIH----------------------------AVHHLFL--------IWLSVYPLCS----------------------------------------QGSWMWLGIT-----------------SVGV---------PEKLGC--AH----L-P-LSH------K-QKELC------ARKPHLL-P-SVKEGARLGITECQTQFRHERWNCS--------------------------------T----RRDPNVFG--Y--ELT-S---------------------------G-TKETAFIHAVMAAGLVHAVTRSCSA-GN-MTEC-S-C-DT--------------------------------------------------------------------------SLLGSGSPTEG--------W-------HWGGC-SD-DIAFGTSFSRRFID-SAA-KN--------------------------------------------TS---TRGEEALLIMKQHNSEAG-RQ----AVA--KTMLTDCRCHGVSGS-----CAVKTCWRTMAAFERVGAYLKDRYETSVHV-VDRSKR---------------K-VRRK------------------------------------------------------------------------------DKEQRHVPIT-KD--E-LIF-FNKSP-NYCLEDRRL-GVTG----TRGRKCNR-T------------------------------S--AGPDGCNLLC--CGRGYNTHVVRHVE-RCEC-KFV------WCC--YVRCRR-CETMNDMHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------ELLIL----------AVLFPGRS----------------------------------------FANLMLLSLS-----------------SVGS------SRSGRSVSC--GT----A-PGLIG------R-QKRLC------RKYSHAV-P-SIMDGANKALGECRAQFSQERWNCS--------------------------------T----RGGTQTFE--S--FLG-K---------------------------G-TRETAFIYAITSAAVVHAITQSCSA-GN-LTDC-S-C-GRV-TGDSD-------------------------------------------------------------------TLPARGSDLEG--------W-------KWGGC-SD-DIVFGMEFSKRFVD-AADSRG--------------------------------------------RK---KRSRNIRSMMNLHNNEVG-RK----AIQ--EQMSVKCRCHGVSGS-----CAVKTCWKTLPSFKRVGDFLKKKYMTSVPI-LRKTRR---------------R-LRRK------------------------------------------------------------------------------QKMQRKVPIG-DD--E-LVF-LEKSP-NFCKSDKKR-GIFG----TRGRECNR-T------------------------------S--TGPDSCNLLC--CGRGYNTQVVRFVE-RCGC-KFV------WCC--YVKCNT-CETIIDKHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------ELLIL----------AVLFPGRS----------------------------------------FANLMLLSLS-----------------SVGS------SRSGRSVSC--GT----A-PGLIG------R-QKRLC------RKYSHAV-P-SIMDGANKALGECRAQFSQERWNCS--------------------------------T----RGGTQTFE--S--FLG-K---------------------------G-TRETAFIYAITSAAVVHAITQSCSA-GN-LTDC-S-C-GRV-TGDSD-------------------------------------------------------------------TLPARGSDLEG--------W-------KWGGC-SD-DIVFGMEFSKRFVD-AADSRG--------------------------------------------RK---KRSRNIRSMMNLHNNEVG-RK----AIQ--QQMSVKCRCHGVSGS-----CAVKTCWKTLPSFKRVGDMLKKKYMTSVPI-LRKTRR---------------R-LRRK------------------------------------------------------------------------------QKMHRKVPIG-DE--E-LVF-LEKSP-NFCKSDKKR-GIFG----TRGRECNR-T------------------------------S--TGPDSCNLLC--CGRGYNTQVVRFVE-RCGC-KFV------WCC--YVKCNT-CETIIDKHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----------------------------------------------------ELLIL----------AVLFPGRS----------------------------------------FANLMLLSLS-----------------SVGS------SRSGRSVSC--GT----S-PGLIG------K-QKRLC------RKYSHAV-P-SIMDGANKALGECRAQFSQERWNCS--------------------------------T----RGGTQTFE--S--FLG-K---------------------------G-TRETAFIYAITSAAVVHAITQSCSA-GN-LTDC-S-C-GRV-TGDSD-------------------------------------------------------------------TLPPRGSDLEG--------W-------KWGGC-SD-DIVFGMEFSKKFVD-AADSRG--------------------------------------------RK---KRSRNIRSMMNLHNNEVG-RK----AIQ--QQMSVKCRCHGVSGS-----CAVKTCWKTLPSFKRVGDFLKKKYMTSVPI-LRKTRR---------------R-LRRK------------------------------------------------------------------------------QKLSRKVPIG-DD--E-LVY-LEKSP-NFCKSDKKR-GIFG----TRGRECNR-T------------------------------S--TGPDSCNLLC--CGRGYNTQVVRFVE-RCGC-KFV------WCC--YVKCNT-CETIIDKHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAVI-------------QRSCLKG---------------------------PIQVLIL----------VFLLTGKS----------------------------------------FASWLWLGVA-----------------SVGTVS---SPQEAEEMVC--SV----V-PGLVT------A-QKTVC------IKKPQTI-V-SVSEGARLGITECQKQFQRERWNCS--------------------------------T----TDDDSVFG--K--ILE-Q---------------------------G-NRETAFIYSVTTAGVVYAVTRACSA-GN-LTDC-T-C-DRE----------------------------------------------------------------------------HGETHEEG--------W-------NWRGC-SD-NIHYAIGFSKTFVD-APD-KA-------------------------------------------------FKGDLLRSLMNLHNNEVG-RK----AIE--EQMDIQCRCHGVSGS-----CNVKSCWKTMPHFPNVGDYLKTRYESSVEL-HPRAKK---------------R-LRRK------------------------------------------------------------------------------DRKNRKVPIN-TT--E-MVY-MDQSP-NYCMEDTLN-GVPG----TSGRECNR-T------------------------------S--LLADSCDLLC--CGRGYNTQVVRYVE-RCGC-KFI------WCC--YVKCNT-CETMIDRYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMATG------------------------------SRRRGSNPREW------SLAALWLGAAI----GLLSQGPVGA----------------------------------------SATWMYLGIA-----------------HLGSAT-------TSTHSC--HI----L-PGLVY------Q-QLRVC------EENPHTM-P-CVSYGARVGIEECHHQFKKERWNCTTPEDE---------------------------A----TGGINLFG--Q--ILK-R---------------------------G-TKETAFMYAVTSAGVVHAVTKACSS-GN-LTDC-T-C-DLS---------------------------------------------------------------------------QQGQTSGEG--------W-------KWGGC-SD-NVDYGMWFAETFVD-APE-KL--------------------------------------------RH---TASKDIRSLMNLQNNAVG-RQ----VIN--DQMNLKCRCHGVSGS-----CAVKTCWRTLTSFREAGNELKQKYENSISI-AEKSKR---------------K-LRQR------------------------------------------------------------------------------QRRQRQRRTS-NNGLD-MVY-IEDSP-NYCRKNMKR-GILG----TKGRECER-D------------------------------P--DARDSCNTLC--CGRGYNTEVVRFVE-RCQC-KFV------WCC--EVKCKI-CETITDKQTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN-----------------YIRLS----------------------------ILSACII--TVKD----IEEYPFSK-----------CDFL----------------------FSNRIIFWYLGVA-----------------SLAGSL-------QEQENC---D----I-PGLVI------Q-QKEVC------QKNPESV-Y-CIGEGARRGILECQKQFKFERWNCT--------------------------------L----IGNNTVFG--H--VLS-K---------------------------G-TREAAFIYAILSAGVVHSVTQSCSA-GN-LTDC-S-C-DMS--------------------------------------------------------------------------KYGRENKGEG--------F-------QWGGC-SD-NVDYGLKFSRGFVD-APE-IV--------------------------------------------RH---EDSRDIRNLMNLHNNEVG-RQ----IVE--KNMQLRCRCHGVSGS-----CAVRTCFRSLPNFRKVGLELKDKYEKSVRL-ARRSRK---------------R-LRRK------------------------------------------------------------------------------DKTKRKQGIS-KQ--E-LVF-VHRSP-NYCKEDIKR-GIFG----TRGRVCNR-S------------------------------S--PTEESCDLLC--CGRGYNTQVVKYVE-RCHC-KFF------WCC--YVKCKT-CETMMDIHTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-----------Y----RTVRLR---------------------W------PFSLVWW-----------TVLIVDA----------------------------------------NASWWWMGIS-----------------ASGS-----ISGNSVSPSC--SR----V-PGLSL------Q-QLRMC------LQKPDVI-P-SVSQGANIGIHECKKQFKYERWNCS--------------------------------T----SNDPTVFG--T--LLK-I---------------------------A-HKESAFVYAITSAGVVHAVGKSCSK-GN-LTEC-S-C-E-S--------------------------------------------------------------------------KRGARNQPKG--------W-------EWGGC-SD-NVNYGVWLSKTFVD-APE-KAD------------------------------------------RRA---RSQRKARAMMNLHNNEAG-RE----AVL--ALMRVQCRCHGVSSS-----CAVKTCSKSLPKFEEVGEALKAEYKDAIRAVYIKRKR---------------K-LKRK------------------------------------------------------------------------------DNKKLR--IP-SS--S-LVY-LDESP-NYCYRDKKL-GIDG----TSGRECNK-N------------------------------S--SGVDGCDLLC--CGSGYNTQTVRSVH-SCHC-RFI------WCC--NVVCKK-CEKIFDRYTCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------YISLK---TSQNFKETGWLTRHEDESWDLRFH------------------ASEIPSRQPSSVSRTNFTTRDFLRTLEKNGF----------GENPHVKSTRTYPYTRSHKVQMHSISNKNTNPTLASGKKLH-ESTWRQNEEWC--SW----F-RGLAP------R-QHRMC------LENPDLV-A-AAMRGTDIAVRECQRQFSYDRWNCS-LILTNVVVRSRTRSDQHLSYVNQKGGGGYRKE----DIKGEVLA--R--GLR-N---------------------------A-TREGAFVHAIMSAGIAHAVTVACRT-GK-LNGC-H-C-DKS-ISKLDIAMEILREKIAWDESKYTLN---AAKA-AFDAVKRRKLYGGFYSGLHNGSNAAFT------------TGISWEDEVEE--------I-------SWGGC-SD-DVKFGVRFSRRFVE-APY-KD--------------------------------------------VP---LRKRTPRDDVNLHNGEVG-RR----MIQ--SMTRVHCRCHGMSGS-----CTTQTCWMQMASFEDIGDALKRKYTSAIQA-LDESKR---------------R-RRLR--HMTV--------------------------------------------------------------------HSYDIDSGRLRRVP-KT--E-LAF-INPTP-NLCRENRTL-GMAG----TAGRECLK-H------------------------------S--EDAGDCRYLC--CGRGYNTRQVVIRK-HCKC-KFI------WCC--EVLCEI-CSEMTTKYTCKE--------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------YISLK---TSLIFKEAE-CSRHEDENWDSGFH------------------ASEIPSRQPSSVSRTNFTTKDFLRTLEKNGF----------GENPHLKSTRTYPYTRSHKVQMHSISNKNTNPTSASGKKLH-ESTWRQNEEWC--SW----F-RGLAP------R-QHRMC------LENPDLV-A-AAMRGTDIAVRECQRQFSYDRWNCS-LILTNVVVRSRTRSDQHLSYVNQKGVGGYRKE----DIKGEVLA--R--GLR-N---------------------------A-TREGAFVHAIMSAGIAHAVTVACRT-GK-LTGC-H-C-DKS-ISKLDIAMEILREKIAWDESKYTLN---AAKA-AFDAVKRRKLYGGFYSGLHNGSNSAFT------------TGIAWEDEVEQ--------I-------SWGGC-SD-DVKFGVRFSRRFVE-APY-KD--------------------------------------------VP---LRKRTPRDDVNLHNGEVG-RR----MIQ--SMTRVHCRCHGMSGS-----CTTQTCWMQMASFEDIGDALKRKHTSAIQA-LDESKR---------------R-RRLR--HMTV--------------------------------------------------------------------HSYDIDSGRLRRVP-KT--E-LAF-INPTP-NLCRENRTL-GMAG----TAGRECLK-H------------------------------S--EDAGDCRYLC--CGRGYNTRQVVIRK-HCKC-KFI------WCC--EVLCEI-CSEMTTKYTCKE--------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------LIHMF---SSQHFEIASQLSHAIKNGNTKR---KLVTLLLGGTS------AAQPPNDD--------------------------------------TEYGRWGDTQST---------------------ETQ-RATKRKIESWC--MS----L-PGLVT------R-QQRMC------VSNPALV-A-AAAQGTEIAVKECERQFMHMRWNCS-LIFNQYTKT-RRRAVDG-TIVERKSG---RME----VGREGVLA--P--G-------------------------SFFLFIA-TKEAAFLHAIMSAGIAYSVTLACRS-GE-LYNC-H-C-DKS-VTKLDIDIEILAE--------------------------------------------------------------------KI--------L-------SWGGC-SD-DVRYGVRYSRRFVE-APY-KG--------------------------------------------IP---RRKLSTIDAINLHNSEVG-RR----IVQ--SLRRMHCRCHGTSGS-----CNVQTCWMQMASFQEVGDRLREKYMSAIQA-DPTPSM---------------P-WKITKPTFTIFI------------------------------------------------------------------KLYLSDSGRLRSVP-KT--E-LGF-VNQTP-SLCSRDDNL-GILG----TAGRKCLK-H------------------------------S--GDSGDCRYLC--CGRGFNVKEIRTVK-RCEC-KFV------WCC--RVHCKE-CEVFTEEYTCKA--------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA----------------FVVHMLC--SSQLFEIASQLSPAIKNGDTER---K----LLGGTS------AAQPPNDD--------------------------------------TEYGRWGHTKNT---------------------ETQ-RATKRKIESWC--MS----L-PGLVT------R-QQRMC------ISNPALV-A-AAAQGTEMAVKECERQFVHMRWNCS-LIFNQYTKT-RRRAVDG-TIVERKNG---RME----VGREGVLA--P--GLA-ND--------------------SFPFNLA-TKEAAFLHAIMSAGIAYSVTLACRS-GE-LYNC-H-C-DKS-VTKLDIDIEILAE--------------------------------------------------------------------KI--------L-------SWGGC-SD-DVRYGVRYSRRFVE-APY-KG--------------------------------------------IP---RRKLSTADAINLHNSEVG-RR----IVQ--SLRRMHCRCHGTSGS-----CNVQTCWMQMASFQEVGDRLREKYMSAIQA-DPYHLLR--------------R-TTLQQSHITIFT------------------------------------------------------------------TSYVSDSGRLRSVP-KT--E-LAF-VNPTP-SLCTRDDNL-GILG----TAGRKCLK-H------------------------------S--GDSGDCRYLC--CGRGFNVKEIRSVK-RCEC-KFV------WCC--RVHCKE-CEVFTEEYTCKA--------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---------------------------------------------------------LGGTS------AAHAPSGRYSEMSSRQTRVSEIERMNSLNGG----------IEG--SESGRTSSLKRT-----------------GSPYELL-RNMKRKTEAWC--LS----L-PGLVP------R-QQRMC------ITNPALV-A-AAARGAEMAVKECERQFKHMRWNCS-LIFNRHSSAGRRRAAGG-TVVD--SD---RVS----KGQDDVLA--P--GLR-N---------------------------A-TKEAAFLHAIMSAGIAYSVTLACRT-GD-LLDC-H-C-DNT-VNKLDIDIEILAE--------------------------------------------------------------------KI--------V-------SWGGC-SD-DVRYGVRYSRRFVE-APY-KG--------------------------------------------IQ---RRRLTSTDAVNLHNSEVG-RR----VIQ--SLRKMHCRCHGMSGS-----CNVQTCWMQMASFQEVGDCLRDKYSSSMLA-HHDGKR---------------Q-RRLK--YVTVVI------------------------------------------------------------------VFLSTDSGRLRRIP-KT--E-LAY-SNKTP-SLCKRNEDI-GILG----TEGRKCLK-H------------------------------S--GDFSDCRYLC--CGRGFNVREIRTVK-RCEC-QFV------WCC--KVRCNQ-CESTTEEYTCKA--------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------------------------------------------------------------PTLS------------------------------------AFRERQKTTETRKT-----------------SESRKHQ-RKMRKLRQRLC--RS----L-PGLVR------R-QYKMC------MDSPELV-A-AAVDGTAIAISECERQFKYERWNCS-LLMRRSKKMWLTLFAGF------------KSY----TALSVVTE--H--DIL-S---------------------------A-TRESAFVHAILGAGIAHAVTTSCKR-GE-LPGC-H-C-DMN-VSKLNLAMKVIGGFISSNEGGSNDDYEAITMA-TLNALRKRKLYGAASNSMLENRTWTLSR--------NSKGQIALVDDLKK--------I-------SWGGC-SD-DVRFGIRFSRKFLE-APY-RG--------------------------------------------VP---KKQRKIQDDVKLHNGEVG-RR----IVQ--ELTRVHCRCHGMSGA-----CTSQTCWLQMPTFHEVGNALKLKYMDGAVR-ARQLKR---------------R-RRLR--HVTV--------------------------------------------------------------------NSYDIDSARLRTVP-KT--Q-LAF-LNDTP-NLCFRNESL-GVEG----TVGRQCLK-N------------------------------S--DGRGGCKRLC--CGRGHAVKKVVRQW-NCKC-KFF------FCC--RVECDT-CVETRNVYTCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNCAT----------VIRRLVPVERVTGSRLEPVIECMSLANP--------IVLTQRVLDGPRHVESSFQSHFPSDE-------------------------------------------------------------------SFNEETPKRNVTINLPVYC--SKG---RRA-LSH------L-QWNIC------SLDASSA-V-AADQGYWKAIKLCETEFKYEKWNCS-LVLPR--SRNHKR----------------NTS----RFNDGVLP--I--GLE-D-----------------------------TKEAAYYYAITRAGIAHSITRSCST-GA-VPGC-K-C-Y-EGFKTRNFVKHVHN----------------LCIN-PVEVKVTG--------------NYIRSKSTSSVELPHGVSSTENCTSDVT--------W-------EWRGC-SD-NINYGVRQSKKWFE--PNSKR--------------------------------------------RK---KRLMTSSDKLNLHNANVG-RR----VYE--DLTALNCVCSGLSGS-----CALRTCWKRHPDLRVVAAELKKLYKKARPV-VLATQT---------------R-NPTR--------------------------------------------------------------------------YKITTGSGRVRKLF-KK--E-LAY-FNRTP-DLCEPDEIT-GSLG----TKKRECKL-R------------------------------S--NDAGDCRRLC--CRRGFYDVTKEITY-TCNC-QFH------FCC--RVTCQV-CRRSETLHICNG--------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt16 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRHYKTPLLEQFSVND-------------------------------------------------------------------VITEPTREARVNLRHPNFC--RKR---RKAGLSR------L-QRNIC------ALSPAPA-V-AAAEGYNDALKLCAREFRYERWNCS-LVLPR--NRFHRR----------------NAS----KYNDGVLP--P--GLE-D-----------------------------TKEAAYYYAITRAGIAHSITRSCST-GV-LPGC-K-C-Y-EGFKPRNLVREVHK----------------ICRN-PVDVKVTG--------------SAVKSKSVSAEQLPDSVSSIENCTSDVT--------W-------KWRGC-SN-NINYGVRQSKRWLE-SAT-RG--------------------------------------------RK---SRLLTSSDKLNLHNANVG-RR----VYQ--DLTEMRCVCSGMTGS-----CALRTCWKRHPDIRVVAAELKRLYGKAKVV-SSTTRH---------------K-NPSR--------------------------------------------------------------------------YLIITGSGRVRKVF-KK--E-LAY-FNPSP-DFCEADELT-GSLG----TEHRECKL-R------------------------------S--NDSGDCRRLC--CRRGFYDITRESTY-QCLC-EFQ------FCC--KVTCQV-CRRSETIHLCNS--------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKNDHYCWNKTIFYNQIICYVCFD----------------------------CREVGIL--AVSHRQPLPSEFSVNA-------------------------------------------------------------------GITSQPV-KQQPVPLPDWC--RES---R--GFSA------L-QMGIC------SMEPVVA-S-AAMKGYKMALKYCTAEFAHEKWNCS-LARNIWEEKSNTK----------------NVS----KFDDNVLP--S--GLR-D-----------------------------TKEAAFYYAITRAGIAHSISEACTK-QQ-TEGC-K-I-GTEGFSQDNILRAIRKSQ----------N---LIIP-LLNQVVSR--------------SWIVKK------------AIAELNFSQE--------W-------QWGNA-SH-NIEHGIKYSRKQLE-DGF-NG--------------------------------------------KH---ANRLPTSDRLNLHNTNVG-RR----VYE--KAVLLVCKCHGMSGS-----CATRTCWRRQADFRKVARELKNIYFAAKRV-SKPQSG---------------N-RNTD--------------------------------------------------------------------------RYLYYGSKRRRKLN-KG--Q-LAF-TRKTP-NLCQRSNRL-GITG----TRGRSCSN-I------------------------------S--EAA--CQRLC--CGRGYTTHLVRVQT-KCDC-EFS------WCC--DVTCST-CEKLQVLRICQR--------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt16 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-------------------VHFV----------------------------YREIGVL--AVSHRQPLPSEFSVSA-------------------------------------------------------------------GIRSPPP-HQHPVLLPDWC--KES---R--GFSA------L-EAGIC------SMDPVVA-T-AAVKGYKMALKYCTAEFAYEKWNCS-LARNIWEAKSHSK----------------NIS----KFDDDVLP--S--GLR-D-----------------------------TKEAAFYYALTRAGISHSITEACTK-QQ-MEGC-R-I-GPDGFAQDNLLRAIRKSK----------N---LIIP-LLNQVVSR--------------AWIVKK------------AIAEVEF--E--------W-------QWGNA-SH-NIEHGIKYSKKQLE-NGF-NA--------------------------------------------KQ---ANRLPTSDRLNLHNTNVG-RR----VYE--KAVLLVCKCHGMSGS-----CATRTCWRRQADFRKVARELKNIYFAAKRV-SKPKSG---------------S-GNTD--------------------------------------------------------------------------RYLYYGAKRRRKLS-KG--Q-LAF-TRKTP-NLCQRNHRF-GIQG----TRGRSCDN-I------------------------------S--ESA--CQRLC--CGRGYNTHLVRVQT-KCGC-EFS------WCC--DVTCST-CEQLQVLRICKR--------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMQQCETEMSGERWDCP---------------------------TTTNIKDPITQMDINPFD--L--MLG-T---------------------------G-TRESAFLHSIITAGGAFSIAAAEAR-GQ-LKKE-R-I-DHC-STN---------------------------------------------------------------------SESEQNTDQKK--------FYLTEKYSKYGACVSD-NF-Y------KP-DSAGH----------------------------------------------------------IEKIHHHNARQG-LK----TLE--KTMVEHCRCHGLSGS-----CHEKTCWKSLSSFEAISSATFAKFKKAKRA--K-------------------SANAID------------------------------------------------------------------------------------SSKY-ND--K-LVY-SEKTP-SKCEKDEKF-GMLA----SEGRECTL-T------------------------------K--GP-NSCKKLC--CKGKYEKVKTKIIE-KSNC-KFN------WCC--SVECDE-KEIEKTKYYCI---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQ--GPWWVTILLP--SLLLSAVVPADGLWWLVPWALQLNMTYTARPTNISAPFSSPRLINKPGGARGGS---------------------NAIRWSTGEARRYC--GAV-----PWPVR------R-QKIMC------EKFPRAT-T-KVREGANLGIQECQHQFKHRLWNCST-------------------------------------ADISVLQ--R--LLSIR---------------------------S--RETAFLHAIVSAGVAYGVARACST-GELQ-EC-S-C-SKAKTK----------------------------------------------------------------------PPPGAESAGGE--------W-------EWGGC-SH-NIRFGDNLSKEFMD-ANEV---------------------------------------------------A--ADDTGLMNLHNNEAG-RK----SIK--ANMKVTCKCHGVSGS-----CATMVCWESMPSFRQVGDIIMGKYHGATYVKINKKGS---------------R-LRPRNKR----------------------------------------------------------------------------------HKRPTAH-D-VVY-LDDSP-DYCEVDVAK-GSYG----TRGRKCNR-T------------------------------SA-GVDG-CQLLC--CNRDFVSREETTEE-SCNC-KFK------WCC--EVTCKK-CKKKELVHYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_WntA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTYTARPTNISAPFSSPRLIGNP-GARGGS---------------------NAIRWSTGEARRYC--GAV-----PWPVR------R-QRIMC------EKFPRAT-T-KVREGANLGIQECQHQFKHRLWNCST-------------------------------------SDVSVLQ--R--LLSIR---------------------------S--RETAFLHAIVSAGVAYGVARACST-GELQ-EC-S-C-SKAKNK----------------------------------------------------------------------PPPGAESGGGE--------W-------EWGGC-SH-NIRYGDTMSKEFMD-ANEV---------------------------------------------------A--ADDTGLMNLHNNEAG-RKARPSAIK--THMKVTCRCHGVSGS-----CATMVCWESMPSFRKVGDIIMAKYHGATYVKINKKGS---------------R-LRQRNKR----------------------------------------------------------------------------------HKRPTAE-D-VVY-LDDSP-DYCQADLAK-GSYG----TQGRRCNR-T------------------------------SA-GVDG-CQLLC--CNRDFVSREETTEE-SCNC-KFK------WCC--EVTCKK-CKKKELVNYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISSSPARVQSRHSPSSLLFSFLL-------------------------LSLPF---MLLSKP-GARGGS---------------------NAIRWSTGEARRYC--GAV-----PWPVR------R-QKIMC------EKFPRAT-T-KVREGANLGIQECQHQFKHRLWNCST-------------------------------------ADISVLQ--R--LLSIR---------------------------S--RETAFLHAIVSAGVAYGVARACST-GELQ-EC-S-C-SKAKTK----------------------------------------------------------------------PPPGAESAGGE--------W-------EWGGC-SH-NIRFGDNLSKEFMD-ANEV---------------------------------------------------A--ADDTGLMNLHNNEAG-RKARPLAIK--SNMKVTCKCHGVSGS-----CATMVCWESMPSFRQVGDLIMGKYHGATYVKINKKGS---------------R-LRQRNKR----------------------------------------------------------------------------------HKRPTAH-D-VVY-LDDSP-DYCEVDVAK-GSYG----THGRKCNR-T------------------------------SA-GVDG-CQLLC--CNRDFVSREEITEE-SCNC-KFK------WCC--EVTCKK-CKKKELVHYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MD------NVRNFLRITLLLSIFL--------------------VPTTNSSWW-----YLGLSSSTYRNT-----------------------LTSTTLHHRSKC---SQ---I-DVLAP------H-QRELC------SKSKNVL-D-IVAVGAGMGIDECQHQFRDRRWNCTTY------------------------------------NDTDVFG--K--VLDLK---------------------------T--REKAYIYAVSSAGVMFAVTTACAK-GELH-IC-D-C-DEKVRS---------------------------------------------------------------------------QDTKGG--------F-------IWGGC-SH-NVAFGDRFTREFVD-SNEN---------------------------------------------------R--FNDEGLMNLWNNNAG-RK----AIR--TSMKLLCKCHGVSGS-----CSAKICWKTMTGFRNIGSQLKDKFDGASRVIHHDKKH---------------R-LKPMDRY----------------------------------------------------------------------------------QKKPNKK-D-LVY-LQESP-DFCSSNTTI-GSLG----TQGRACNK-T------------------------------SY-GLDG-CSLMC--CGRGYQTTLITVVE-DCNC-KFV------WCC--NVVCDE-CIKREERHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR--------RFLEKIIVILAVLQ----------------------IVHSSWW-----YLGVSSSYQSLV-----------------------EEIKHLPGRKRC---SN---L-AFLAP------R-QQELC------GLEEKII-D-VIHDGASMGIDECQHQFRDRRWNCTTF------------------------------------NTTNVFG--Q--ILKIK---------------------------S--RETGYIYAILSAGIMYSVTRACAK-GDLD-HC-G-C-DTKVRR---------------------------------------------------------------------------ISTEGE--------F-------EWGGC-SD-NIRYGSKFSKDFVD-SKEM---------------------------------------------------R--ISEDGLMNVWNNGAG-RK----MVK--DELELMCKCHGVSGS-----CSVKICWRKMKSFRAIGSALKGRFDGASLVKMDRRRK---------------R-LKRTNKL----------------------------------------------------------------------------------QKRPTKK-D-LVY-LNESP-DFCEHNLEN-GSVG----TRGRECNK-T------------------------------SY-GLDG-CRLMC--CGRGYYTLIKEEKD-DCDC-KFY------WCC--RVECKK-CTNVKEMHYCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQ------ISTYLPLFIGLFSIKL--------------------------QAEFSYDRFVQVLPGRKTLSI--------------------KTGAWQPSDVTHYC--DS----M-TWLSQ------R-QRELC------LRHPDII-A-NAERGAEYGHTECQHQFRNQRWNCSIE------------------------------------NATDIFS--KRTITKAR---------------------------S--AETAFVHAVMSAGVTYSVTRACGM-GILE-EC-G-C-DTKYLP---------------------------------------------------------------------------SSEESN--------W-------NWDGC-ND-NIGYGMYFSRDFMD-AIED---------------------------------------------------D-LINGLSLMNIHNNEAG-RQ----VIK--HEMYTKCKCHGVSGS-----CTSKICWRTMRKMRDIGDILMDKYFQAIRVKYAKKRK---------------R-LRPHSKT----------------------------------------------------------------------------------GARLPVT-E-LVY-LDTSP-DWCEPNKKY-FSHG----THGRFCNK-T------------------------------SR-NSDS-CALMC--CGRGYQIMERRVEE-SCNC-RFH------WCC--VVTCES-CIRDEELHICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR------FSRRPRVSSVLTAYFM----------------WSWSALLASAAWW-----LLTVPPMTERYE------------------------NTSARGAKVYC--DS----L-RYLKP------Y-QYQRC------LRQPTLM-A-VISDGIKSGIRECQYQFRNSKWNCSTY----------------------------P-G----PPGRHAFH--P--ILKAR---------------------------G--REKAFVYAILSAAVSYEITRACSN-GAMLSEC-G-C-AKINPH--------------------------------------------------------------------------DRKRGGN--------F-------VWGGC-SD-DVKIGDEISRSFLD-GDIV---------------------------------------------------T-AKSMKKQLRKHNSEAG-RM----VVT--SNMRKVCKCHGITGS-----CAQTVCWRSMPTLRFISHRIKQRFDGSVQAR--IRKG---------------I-LRPRNKK----------------------------------------------------------------------------------HKNPTAL-D-LVY-AKPSQTNFCEPNLKR-GSYG----TRGRVCNE-S------------------------------SI-ANDH-CGIMC--CDRGYHVETFMRPY-GCNC-VFE------WCC--QVKCQE-CRERVTLSYCS---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MR------LTSRSRI-SFLAAYFL----------------WSWSALLASAAWW-----LLTVSPMSERYE------------------------NTSDQGAKLYC--DS----L-RYLKP------H-QYQRC------LRQPALM-A-KISDGVKSGIRECQYQFRNSKWNCSIY----------------------------P-G----PPRKHAFE--P--ILKAR---------------------------G--REKAFVYAILSAAVSYEITRACSN-EALPTEC-G-C-AKINMH-------------------------------------------------------------------------------RR--------F-------LWGGC-SD-DVKFGDEVSRSFLD-GDLD---------------------------------------------------S-PKSMKKKLRQHNSEAG-RS----VVT--NNMRRICKCHGITAS-----CAQTVCWRSMPTLRYISDTIKQRYDGAVQAKR-IRKG---------------G-LKAKNKR----------------------------------------------------------------------------------HNNPTPR-D-LVY-AKPSQTDFCEENLKR-GSFG----TRGRVCND-S------------------------------NIAATDH-CALMC--CDRGYRTETFMRPY-GCNC-VFK------WCC--QVKCEE-CRKRVTQSYCL---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_WntA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLNVPTPNSDQQ------------------------TRNSKGARAYC--NS----L-KYLTD------K-QKSMC------IHSPTIM-S-KISHGVIAGMRECQLQFQHRRWNCTPYQ---------------------------S-N----NPKTHAFE--P--VLKNK---------------------------G--PERAYIKAMLSAAVSYKITRACSG-GELPLEC-M-C-ANIKRP----------------------------------------------------------------------AKDDPEDPKKK--------F-------EWGGC-SD-DVNFGDSRSREFFD-ESDL---------------------------------------------------S--RNQGRVLDIHNNEAG-RK----SVK--MSNRTTCKCHGLTGA-----CTQNICWRSLPPLRRIGKELFQRYNSAVRVKT--RKL---------------D-IQG----------------------------------------------------------------------------------------KATSN-D-LVY-VRKSP-SFCIKN-NR-GSYG----TAKRWCNR-T------------------------------ST-ETEG-CAHMC--CGRGYRTEEKIKIT-ECNC-EFQ------WCC--NLNCYF-CEENVEESYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_WntA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLNVPAPNSDQQ------------------------TRNSKGARAYC--NS----L-KYLTD------K-QKSLC------IHSPTIM-S-KISHGVIAGMRECQLQFQHRRWNCTPYQ---------------------------S-N----NPKTHAFE--P--VLKNK---------------------------G--PERAYIKAMLSAAVSYKITRACSG-GELPLEC-M-C-ANIKRP----------------------------------------------------------------------AKDDPEDPKKK--------F-------EWGGC-SD-DVNFGDSRSREFFD-ESDL---------------------------------------------------S--RNQGRVLDIHNNEAG-RK----SVK--MSNRTTCKCHGLTGA-----CTQNICWRSLPPLRRIGKELFQRYNSAVRVKT--RKL---------------D-IQG----------------------------------------------------------------------------------------KATTS-D-LVY-VRKSP-SFCIKN-NR-GSYG----TAKRWCNR-T------------------------------ST-ETEG-CAHMC--CGRGYRTEEKIKIT-ECNC-EFQ------WCC--NLNCYF-CEENVEESYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_WntA --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLLNVPPHDPTEH------------------------TTSTKGTKLYC--NS----L-RFLSQ------R-QRELC------IQHPDIM-R-KISEGVHLGVRECGYQFRNSRWNCTMY----------------------------P-G----RPKQHAFE--P--VMRNK---------------------------G--KERAYINAILSAAVSFTVTEACSR-GELKLDC-G-C-ARMKRN------------------------------------------------------------------------YDHEARRRS--------F-------EWGGC-SD-DVTFGDGISRDFFE-ENIRN--------------------------------------------------S--LKGLEVLDLHNKAAG-RR----EIV--RNTVTACRCHGITGS-----CQQNVCWRAKPRIRNVSTELFQRFNSALKVRV--RKS---------------R-VHPV-KS----------------------------------------------------------------------------------RRSLELS-D-LIY-LRNSP-KFCKANLSR-GSYG----TAGRRCNG-T------------------------------TT-GPGS-CSYMC--CNRGYNTVEETKES-SCNC-KFE------WCC--NVNCDT-CREMQVENYCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_WntA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLDVKPPAEEQE-------------------------HRPRGHRQYC--ES----F-PHLTR------K-QRNYC------HHHPQVL-A-KVSEGYRDAIQECQFQMKDRKWNCPTHDDS-------------------------E-K----DAKKHVFD--P--VLKLR---------------------------G--KERAFIQALFSAAISYTVTRSCTL-DKLNTDC-G-C-AEA------------------------------------------------------------------------------PPHGQK--------L-------PWGGC-SD-DISFGIGASKIFMD-DIKR---------------------------------------------------P--KSANSKIDLHNNKVG-RM----TIQ--RYKHTTCKCHGLSGA-----CTQNICWVSLPTMKEVGASLKASYDNATQVKS--KKGK--------------F-VSTSTSK----------------------------------------------------------------------------------RPKAEDL-D-LIY-TKSSP-SFCNRNKRQ-GFSG----TSGRLCDP-T------------------------------SP-NENG-CINMC--CGRPHTTKVVKEEI-NCRC-VFL------YCC--ELKCQT-CTKMYNQSRCT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_WntA ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLDVKPPTEEQE-------------------------QRPRGHRQYC--ES----F-PHLTR------K-QRNYC------HHHPQVL-A-KVSEGYRDAIQECQFQMKDRKWNCPTNDDD-------------------------S-K----DSKKHVFD--P--VLKLR---------------------------G--KERAFIQALFSAAISYTVTRSCTL-DKLNTDC-G-C-AEA------------------------------------------------------------------------------PPYGQK--------L-------PWGGC-SD-DISFGVGASKIFMD-DIKR---------------------------------------------------P--KSANSKIDLHNNRVG-RL----VSD----AHTTCKCHGLSGA-----CTQNICWVSLPTMKEVGASLKSSYDNATQIKV--KKGK--------------F-VQTSTSK----------------------------------------------------------------------------------RPKAEDL-D-LIY-TKFSP-SFCNRNKRQ-GFPG----TSGRLCDP-T------------------------------SA-KEHG-CRTMC--CGRPHTTKVVKEEI-NCRC-VFL------YCC--ELKCQT-CTKMYNQSRCT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_WntA --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYI----------------NKYLELKIYHC------RWLNVVPPRPDQE------------------------LNSER----YC--GS----F-P-LTK------N-QREIC------NRHPRIL-S-KVSEGIRDAIAECQNQMQHKRWNCSLYIDF-------------------------R-N----DPKRHVFE--P--IMKQR---------------------------G--KERAFIQALFSASISHAITRSCTL-DKLPNDC-G-C-AVI--------------------------------------------------------------------------------PNSR--------G-------EWGGC-SD-DLHFGDGLSASFMD-DVKN---------------------------------------------------R--KSSSSQLDLHNNAIG-RQ----TVL--KYNHTKCKCHGLSGA-----CTQNICWVSLPTMREVGRRLREKYDDAVQVKY--KKGK--------------F--RSSGKK----------------------------------------------------------------------------------NFK---N-S-LIF-IKKS--NFCKTNIKL-GSFG----TTGRICNS-S------------------------------SA-QSDG-CKHMC--CGRNFTTEVVRVRY-NCNC-TFQ------YCC--HLSCEI-CERDIQQSRCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA------VSVAVITLAILLSEQA--DGRR------------------------KFRDNPVIPSARPSLV-------------------------TSEE-VTQFC---S----LMPWMKP------H-QKQKC------LLEPLVM-P-SVQRGVGMALEECPSHYSDHKWNCSGV------------------------------------NTAQVFQ--ERGILKTN---------------------------T--KESAFVFALTSAGVSFQITKGCSL-GNWE-QC-G-C-DTQVRG------------------------------------------------------------------------RVQTKDEAS--------W-------EWGGC-SE-NVGHGDDFSRKFMD-PEPP---------------------------------------------------R--KELEYLLVKHNNEAG-RK----ALK--DNMGKTCKCHGVSGS-----CTVKICWRTMPNFSVVPQLLRKKFDQATKVKANDKKTKLQRITR------GKR-GKKKRQK----------------------------------------------------------------------------------GRRPSAG-D-LVF-AEKSP-KFCIPNPEL-GILG----TRGRVCDA-N------------------------------AK-DNRG-CKKMC--CNRGYDTFKLSNQV-KCNC-EFI------WCC--KVQCDM-CKKDWTEYRCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_WntA --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLLSIPTYDPRQN------------------------QTT------YC--NS----LGPSLTS------N-EREFC------LKYPSIM-H-KISDGIRLGIKECKYSFRYNRWNCSTY----------------------------E-G----PARRHAFA--P--LLKSS---------------------------KLFLEQAYIQAILAAAVSYELTKTCTK-GLLP-TS-V-C-STKNGMFLSDSGFEPPPPRS------------------------------------------------------QRPRRPKEDKGKV--------Y-------YDARL-SD-NVKVGDNLASEFFK-DT-----------------------------------------------------R--KSLLGALDRHNYKAG-RV----AVT--NSITRKCKCHGLSGS-----CTLIACWDTMRPLREISQQLKGRYDNALLVRGRTRKGT-------------TK-LRPRGRG----------------------------------------------------------------------------------SKKLNET-F-LVYAAKREQ-DYCEKNLAV-GSYG----TKDRWCSA-G------------------------------AD-ANNGSCEHLC--CNRGYKDTVVVVKK-PCEC-MFR------WCC--TLNCEV-CDTTFPGWICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_WntA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRL------------------------------------------------------RLLSIPTYDPRQN------------------------QTS------YC--NS----LGP-LTT------N-ERQFC------LKYPSIM-H-KISDGIKLGIKECKYSFRYNRWNCSTY----------------------------E-G----TARRHAFA--P--LLKSK---------------------------G--REQAYIQAILAAAVSYELTKTCTK-GLLP-TS-V-C-TAKNGMFLPNSGFEPPPVRS------------------------------------------------------QRPRRPKEDKGKI--------Y-------YDARL-SD-NVNVGDSLASEFFK-DT-----------------------------------------------------R--KTLLGALDRHNYKAG-RV----AVT--KSITRKCKCHGLSGS-----CTLIACWDTMRPLREISQQLKGRYDNALLVRGRTRKGT-------------TK-LRPRGKG----------------------------------------------------------------------------------KNKLNET-F-LVYAAKREQ-DYCDENLDV-GSYG----TKDRWCTE-G------------------------------AD-ASNGSCDYLC--CNRGYKDTVVVVKK-PCNC-VFQ------WCC--TLNCEV-CDITFPGWICR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Odi_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-S-------------------------------------------------------------------------------------------------------------------------------------KETKNERQTMS--------------------------------FC--YQPQE-LYPGLQISA--KNR-QRKDC------KLHPAAF-KYSLI-GLKRAEEECKRLLIKHTWNCTGLI-----------------------------S----QTQKSLERNDRTSIMS-K---------------------------S-YQETAFANAMIAAGITYEITKACIK-GQI-DDVKGSC-PRKTSKNHYKEFYIEEDI------------------------------------------------------------------EGT------------------TNC-IDKCVTYAAERAQAFQ-----------------------------------------------------E---R-SPSDHYELARKNQKVGQRL----VF---RSRRESCRCMGPSGS-----CTWKYCVKSIDDFSKIASDLYSKYRERGSLREITYD--------------MHG-QSRPD------------------------------------------------------------------------------------IKRITDL-T-LVY---NSQLDICSQTEER-KAVSIINKNRGRLCKL-PRDDKKTSKRTTVSSRKTSRRKKRRKRRNHLK-QHL-GKCDSIC--CNKSYKEIHRVEKF-KHNM-KFS------WNKEQPLSWDV-RERNVTYGVCT---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT10a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSAHPRPW---------------------------LRLRPQP------QPRPA-------LWVLLFFLLLLAAAMPRSAPNDIL----DLRLP------------------------------------------PEPVLNANT----------------------------------VC--LT----L-PGLSR------R-QMEVC------VRHPDVA-A-SAIQGIQIAIHECQHQFRDQRWNCSSLE-----------------------------T----RNKIPYES--P--IFS-R---------------------------G-FRESAFAYAIAAAGVVHAVSNACAL-GKLKA-C-G-C-DA-------SRRGDEE-----AFRRKLHRLQLDALQ-RGKGLSHGVPEHP-------------------------ALPTASPGLQDS--------W-------EWGGC-SP-DMGFGERFSKDFLD-SR-------------------------------------------------E-PHR---DIHARMRLHNNRVG-RQ----AVM--ENMRRKCKCHGTSGS-----CQLKTCWQVTPEFRTVGALLRSRFHRATLIR-P-HN-------------RNGG-QLEPGPAGAPSP----------------------------------------------------------------------APGAPGPRRRASPA-D-LVY-FEKSP-DFCEREPRL-DSAG----TVGRLCNK-S------------------------------S-A-GSDGCGSMC--CGRGHNILRQTRSE-RCHC-RFH------WCC--FVVCEE-CRITEWVSVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt10a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-SSHDISWHSPASVYFSSDLDVKRIAGKLRGCWTDLLLRQESCCERVLQKSSSSMDYF--LFRLFCSLALASLLVQRADSNEIL----GLKIP------------------------------------------FDPILNANT----------------------------------VC--LT----L-PGLTK------K-QLDVC------MRNPDVT-A-SAIQGIQIAIHECQHQFRGHRWNCSSLE-----------------------------T----RNKIPYES--V--VFS-R---------------------------G-FRESAFAYAIAAAGVVHAVSNACAM-GKLKA-C-G-C-DE-------KRRGDEE-----AFRIKLNRLQLEAIN-RGKGMVHGVMEH---------------------------FPAEALGPQDS--------W-------EWGGC-SP-NVEYGERFSKDFLD-SR-------------------------------------------------E-TYR---DIHSRMRLHNNRVG-RQ----VVV--DHMRRKCKCHGTSGS-----CQLKTCWQVTPEFRTVGSLLKERFNVATLIK-A-HN-------------RNTG-QVENAH--------------------------------------------------------------------------------HTHRRRANIN-D-LVY-FEKSP-DFCERDLGS-DSAG----TQGRICNK-T------------------------------S-Q-GMDNCESLC--CGRGHNILQQTRSE-RCNC-KFH------WCC--YVVCEE-CRITEWVSVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hsa_WNT10b -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------------------------LEEPRP------RPPPSGLAGL--LFLALCS---------RALSNEIL----GLKLP------------------------------------------GEPPLTANT----------------------------------VC--LT----L-SGLSK------R-QLGLC------LRNPDVT-A-SALQGLHIAVHECQHQLRDQRWNCSALE-----------------------------G----GGRLPHHS--A--ILK-R---------------------------G-FRESAFSFSMLAAGVMHAVATACSL-GKLVS-C-G-C-GW-------KGSGEQD-----RLRAKL--LQLQALS-RGKSFPHSLPSPG-------------------------PGSSPSPGPQDT--------W-------EWGGC-NH-DMDFGEKFSRDFLD-SR-------------------------------------------------E-APR---DIQARMRIHNNRVG-RQ----VVT--ENLKRKCKCHGTSGS-----CQFKTCWRAAPEFRAVGAALRERLGRAIFID-T-HN-------------RNSG-AFQPRL-----------------------------------------------------------------------------------RPRRLSG-E-LVY-FEKSP-DFCERDPTM-GSPG----TRGRACNK-T------------------------------S-R-LLDGCGSLC--CGRGHNVLRQTRVE-RCHC-RFH------WCC--YVLCDE-CKVTEWVNVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Dre_Wnt10b -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M---------------------------------------ELP------HRQCLGRVLI--VTAALLSPAF------TVLGNDIL----GLKVA------------------------------------------GEPVLTPNA----------------------------------VC--LR----L-AGLTK------K-QMRLC------VRSPDVT-A-SALQGIQVAIHECQHQLRDQRWNCSSLE-----------------------------N----HGKLPHQS--A--ILN-R---------------------------G-FRESAFSLSLLAAGVVHSVASACSL-GKLRG-C-G-C-EA-------KRRLDDD-----KIRLKLTQLQLQTFQ-RSGVSLAGAGENTPELSSLHGSLPANLHSSHPMSL-LKPLPDEVTMLQDT--------W-------EWGGC-SH-DIRFGVRFSRDWLD-SR-------------------------------------------------G-SPR---DIHARTRIHNNRVG-RQ----VVT--DNMRRKCKCHGTSGS-----CQFKTCWYVSPEFRLVGSLLREKFLTAIFIN-S-QN-------------KNNG-VFNSRTGGSTGS----------------------------------------------------------------------DP-LRGQRRRSISR-E-LVY-FEKSP-DFCDREPAV-DSLG----TQGRICNK-S------------------------------S-P-GMDGCGSLC--CGRGHNILKQARSE-RCHC-RFH------WCC--YVLCEE-CKVTEWVNVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Lgi_Wnt10 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSSANSIL----RLKIP------------------------------------------KIPKLDPNT----------------------------------VC--KT----Y-PDLSE------A-QYDLC------RKYPDVT-A-SAIQGVQVAIHECQFQLAEYRWNCSSLE-----------------------------R----KNKNPHSS--P--LLS-K---------------------------G-YKETSFAYAISSAGVTHQVSKACSM-GKLKS-C-G-C-DM-------SVYGNQQ----------------------------------------------------------------------N--------F-------EWGGC-SH-NINFGAKYASKFLD-SK-------------------------------------------------ERTSR---DIHAQINLHNNRAG-RL----AII--RHVRKQCKCHGMSGS-----CELKTCWKAAPDFRAVGTILKKKYDRATKVQ-V-DI-------------TNSA-NTKLIK---------------------------------------------------------------------------------RNGRIPKHL-E-LLF-YEKSP-NFCDPNPLV-DSPG----TTGRLCNK-T------------------------------S-G-GINNCETLC--CGRGYNTLRVKRTE-RCHC-KFF------WCC--YVTCKT-CEYDEWVTVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cte_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----------------------------------------------IFQYNSGGIIVFFATFLLRCPHHF---VEVQCLSNAIL----PKDLP-------------------------------------------NPALDTSS----------------------------------VC--RT----I-PDLTG------P-QYALC------LKHPDVM-E-VAVQGLKMAMEECQFQFREHRWNCTSMT-----------------------------K----KHNSPYGN--R--LLH-K---------------------------G-YRETAFASAISAAGMSAQIALACAM-GNLPA-C-G-C-NP-------RMETSTQ----------------------------------------------------------------------Q--------W-------VWKGC-QH-NVRFGDYFTRKFWG-SKK------------------------------------------------EATN-----VYSEMDVHNSRAG-RM----IWR--ENVRLHCKCHGMSGS-----CEVRTCWKAASSFRKVGSIIKQKFEQATKVD-T-DN-------------SSKR-SRRLKT-------------------------------------------------------------------------------ARRRKRHIDNT-D-LVY-FERSP-NFCEPDKTL-DSPG----TVGRVCNS-S------------------------------S-L-HIDSCDTLC--CGRGYNTVRLTKIE-RCQC-KFR------WCC--DVLCKK-CLMTSWVTVCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Sko_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----------------------------------------------------------------------------------------TMQTPTPQ--------------------------------------VKYAELDANT----------------------------------VC--GM----V-PGFRR------K-QHRIC------MRTPGLV-A-SAIQGMMVAVHECSYQMRDRRWDCTSLE-----------------------------E----KKQNPFVN--P--IMG-K---------------------------G-YKETAFVHAIASAGVAFQVTRSCAE-GRHPADC-G-C-DK-------TSRTAPP--------------------------------------------------------------------GVD--------W-------KWGGC-SH-NVDFGEEFAQKFLD-IR-------------------------------------------------E-KGR--SDVHSRINLHNNAAG-RS----IVS--RSREKMCKCHGPSAS-----CQIKTCWMSTPKFREIGNIVKQKYDSAIMVS-P-DN-------------NDGR-TWFPSN----------------------------------------------------------------------------------RNRRAKVA-D-LMY-SERSP-DFCEPSAFL-GTPG----TRGRSCNN-T------------------------------S-T-GMDNCDSMC--CGRGYNIKSSSKVE-KCNC-AFH------WCC--FVTCDD-CATSQWVNECK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Nve_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----------------------------------------------DFRG-----------FVKVLLIFFQ--IHSKGFGYGIL----KTSIP-----------------------------------------FEDPVINSNT----------------------------------VC--KN----T-PSLSK------E-QLKMC------RRLPDVV-A-SALQGMQYAIHECLAQFRYRRWNCSSLE-----------------------------M----KNRNPLAN--P--LLS-R---------------------------G-FRETAFVHAILSAGMTSSVARACSM-GKLAK-C-G-C-DE-------SLRGRGT----------------------------------------------------------------------G--------W-------EWGGC-GD-NIDYGIETSAKFLD-SR-------------------------------------------------E-KGR---DLHSMMNMHNNMVG-RT----TLS--ENAKTKCKCHGMCGS-----CSVKTCWKTVPDIREIGDRLMEKYDHATTIG-M-GN-------------GRLR-LHLTRR---------------------------------------------------------------------------------KARRSSVGR-A-LVY-YEDSP-NYCIENKEL-GIFG----TRGRICSP-E------------------------------S-L-DTDNCQNLC--CERGYTTKKLQVTK-RCRC-HFS------WWC--YLICDT-CRETSTVSICS---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hau_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-----------------------RI-------------------------------------------------------QDIL----RLNIP-----------------------------------------DPDPIINTNT----------------------------------VC--GN----T-DGLTR------K-QYELC------KEEPHAV-A-SAIQGFQIAIHECKRLFKHHRWNCSALE-----------------------------T----KNKIPHTG--A--FFN-R---------------------------G-FRETAFSFAIASAGVTHAVTRACSL-GKIRA-C-G-C-EA-------RRRAFSK--------------SLTASQ-HKDLLKNS-------------------------------NKENMEKEFPQ--------F-------MWAGC-DD-DVNFGIKFSRKFLD-ER-------------------------------------------------E-TSR---DHRAMTMLHNNRVG-RL----VVG--DNMRERCACHGSSGS-----CSLKTCWAQTPDIRTVGEIIKRLYHDARKLE-I-SN-------------AIDE-YRSETNIQHPTSIE--------------------------------------------------NKVDFEMPNDLHVTHNN------RKSFGIGVH-I-LVY-FEDSP-EYCYEERSI-NFYG----TKGRYCNK-T-----------------------------AS-PESSNSCSHLC--CNRGHRTFKQTRVE-KCNC-SFH------WCC--YVTCDN-CTVTERVSVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Hro_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-----------------------RI-------------------------------------------------------QDIL----RLNIP-----------------------------------------DPDPIINTNT----------------------------------VC--GN----T-DGLTR------K-QYELC------KEEPHAV-A-SAIQGFQIAIHECKRLFKHHRWNCSALE-----------------------------T----KNKIPHTG--A--FFN-R---------------------------G-FRETAFSFAIASAGVTHAVTRACSL-GKIRA-C-G-C-EA-------RRRAFSK--------------SLTASQ-HKDLLKNS-------------------------------NKENMEKEFPQ--------F-------MWAGC-DD-DVNFGIKFSRKFLD-ER-------------------------------------------------E-TSR---DHRAMTMLHNNRVG-RL----VVG--DNMRERCACHGSSGS-----CSLKTCWAQTPDIRIVGEIIKRLYHDARKLE-I-SN-------------AIDE-YRSETNIQHPTSIE--------------------------------------------------NKVDFEMPNDLHVTHNN------RKSFGIGVH-I-LVY-FEDSP-EYCYEDRSI-NFYG----TKGRYCNK-T-----------------------------AS-PESSNSCSHLC--CNRGHRTFKQTRVE-KCNC-SFH------WCC--YVTCDN-CTVTERVSVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bsc_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-------------------------------------------------------------------------------------------------------------------INTNT----------------------------------IC--GN----A-DGLSK------K-QYEMC------LKNPEAV-A-SAIQGLQIALYECKLQFKNHRWNCSSLE-----------------------------T----RNKIPFTS--D--FFH-T---------------------------G-YREAAFFHAMSSAAVSYAVAHACGL-GKIPG-C-E-C-LA-------GRHREAA-------------SEYYIPP-SQQLIRNG------------------------------GDESEVDANLLQ--------Y-------SWGRC-DH-DINFAMKFSRRFLD-ER-------------------------------------------------Q-SSK---SFYARLTLHNNRVG-RL----VIA--NNMRKKCSCHGMSGS-----CSIETCWQEAPEIHKVGNTLKKLYTAAAKMP-H-DN-------------RVRQ-NSIQIE----------------------------------------------------------NTIR-NIGNSIHRNSRNRRVRGLGRRFGVGLT-S-LVY-WNESP-DYCRIEPSI-NFYG----TNGRQCSR-Q-----------------------------GG-VKKLGSCANLC--CNRGHRTFKETRVE-QCNC-KFH------WCC--RVECAS-CTKFEKMSVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Moccu_Wnt10 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ST------------------------------------------KEPVI--------------------------------------MC--GN----M-KGLSM------R-QHEIC------TDQPHAV-A-SA--GMKVAVHECQFQFKKHKWNCSSLK-----------------------------T----NSDIPHTS--P--FLS-R---------------------------G-FRETAFSYAIAAAGVAHMVAHACHL-GKIEG-C-D-C-QG-------KPKLEDD-------------GLITAGQ-RRELIRN----------------------------------AKMVRGKKR--------F-------QREGC-DF-DIDYALGFSVEFLD--R-------------------------------------------------Q-AS----DQHAVIARHNNRAG-RL----IVA--NKMRQRCKCNGMSGS-----CSLETCWKETPSFRQVGADLKQLYKDAARID-I-SN-------------SISP-QRAL------------------------------------------------------------------------------------DSYGVRVD-Q-LVY-FEDSP-SYCQPDSRI-NFPG----TKGRHCNR-T-----------------------------AG-PNEPDSCEKLC--CGRHYETEPVTITE-KCKC-KFH------WCC--YVNCHT-CQHTETVAVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocul_Wnt10 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ST------------------------------------------KEPVI--------------------------------------MC--GN----M-KGLSM------R-QHEIC------TDQPHAV-A-SAIQGMKVAVHECQFQFKKHKWNCSSLK-----------------------------T----NSDIPHTS--P--FLS-R---------------------------G-FRETAFSYAIAAAGVAHMVAHACHL-GKIEG-C-D-C-QG-------KPKFEDD-------------GLITAGQ-RKELIRN----------------------------------AKMVRGKKR--------F-------QREGC-DF-DIDYALGFSVEFLD--R-------------------------------------------------Q-AS----DQHAVIARHNNRAG-RL----IVA--NKMRQRCKCNGMSGS-----CSLETCWKETPSFRQVGADLKQLYKDAARID-I-SN-------------SISP-QRAL------------------------------------------------------------------------------------DSYGVRVD-Q-LVY-FEDSP-SYCQPDSRI-NFPG----TKGRHCNR-T-----------------------------AG-PNEPDSCEKLC--CGRHYETEPVTITE-KCKC-KFH------WCC--YVNCHT-CQHTETVAVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Mocci_Wnt10 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVF----RLNNP------------------------------------------KDPIINKNT----------------------------------VC--GN----I-RGLTR------K-QLDIC------AKQPRAV-A-AAIQGMQVALHECQHQFRNHKWNCSSLQ-----------------------------T----SGSIPHTS--P--FLS-R---------------------------G-FRETAFSYAIASAGVAHMVAQACHL-GKIED-C-K-C-TG---------KFNEE-------------ALLTAGQ-RKDFER-------------------------------------VNAAKRQ--------F-------QLEGC-DF-DIEFAMQFSVAFLD-MR-------------------------------------------------E-SAE---DQHALIAKHNNRAG-RL----KVA--NKMKKTCKCHGTSGS-----CSLKTCWKETTPFRQIGAELKKLYENAHKIP-I-SN-------------SISP-HLVM-------------------------------------------------------------------------------------DTGAQVN-Q-LVY-FEDSP-LFCEPDKRI-NFPG----TKGRHCNQ-T-----------------------------AP-ADAPDSCETLC--CGRHYDTHLIKDVK-KCNC-KFH------WCC--YVDCME-CLDTKVVAVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Cro_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------------------YDVILTIVITATVQGCFGYQDLFP--YRIPTP------------------------------------------REPVINSNT----------------------------------VC--GN----V-PGLTI------R-QSLVC------ARDPHAV-A-SAIQGMQLAIHECKRQFKNNRWNCSSLE-----------------------------T----KNKIPHTS--S--FLR-T---------------------------G-YKETAFSYAIASAGVTHQVALACSL-GKIDA-C-P-C-QR--------PKK----------------SHLTASE-RRKYAEAR------------------------------RGPSSMEESLEI--------F-------HHSGC-SH-DINFGLQFSTQFLD-SR-------------------------------------------------E-TAH---DFMATARLHNNRAG-RL----VIA--GRMRRQCKCFGKSGS-----CDQKICWDETPDFRMVGKILKKKYDEAVVVG--PLN-------------RLNT-VRDNSL------------------------------------------------------------------------------RLVHEKPSYAAG-D-LLF-FETSP-DYCRADPSI-NILG----TSGRYCNA-T-----------------------------GG-RKQQDSCVNLC--CGRGYRTYTETRTE-KCNC-RFH------WCC--FINCDN-CTYTEDIAICN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Csa_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------------------YLQRCLRF----NLRSLGSPDFFP--SLRPTP------------------------------------------REPVINTNT----------------------------------VC--GN----V-PGLNN------R-QARLC------TQDPHAV-A-SAIQGMQLAIHECKRQFKNNRWNCSALE-----------------------------T----KNKIPHTS--S--FLQ-R---------------------------G-YKETAFSYAIASAGVTHQVALACSL-GKIDA-C-P-C-KV--------PK-----------------AQLSAGE-RRELIVSL------------------------------PTPHAHIQELTQ--------F-------HSGGC-DH-DINYGMMFSSRFLD-SR-------------------------------------------------E-SAH---DFMASTRLHNNRAG-RV----VNGRCQNDEELSACTGQSGS-----CSQRICWAVTPDFKVVGKALKAKYDQAVVVG--PLN---------------SP-IN--SV------------------------------------------------------------------------------RAVTEDVNYTAI-D-LLF-FENSP-DYCRENLSI-N-------VSGRYCNA-T-----------------------------AG-PDHPDSCGELC--CGRGYVTYTETRVE-QCNC-RFH------WCC--FINCDN-CTYTEQVAVCN---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pfu_Wnt10 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLAYKDYYHLGGGHNEP-----------------------------------------RRESRLTTRI----------------------------------VC--GN----V-PGLTP------K-QVALC------NEDPHAV-A-SAIQGLHVGIHECKRQFKNHRWNCSSLE-----------------------------T----KNKMPLNS--V--FLK-KA-------------------------SG-FKESSFAYAITAAGVAHQVAHACSL-GKINE-C-H-C-----------PL--------------------SAGR-RKKIKDSF----------------------------------SAGDNMNR--------F-------KYFGC-SH-NINFAINYSIKFLD--P-------------------------------------------------E-STK---DHTSRVRQHNNRVG-RL----IVG--KNMKRSCRCHGISGS-----CNQETCWYQTPNFREVGEMIKQKYESAQYHGEIPNN-------------DVRP-SNAVSV--------------------------------------------------------------------------------------ASND-A-LLY-YTSSP-RFCSPNHRL-AVAG----TKGRTCSR-T-----------------------------AP-PTDPSSCHHMC--CSRGYETHREVRHE-KCHC-RFH------WCC--YVECQN-CTVSERVSVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Pma_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------------------------------------------FPKR-------RSDSCSRN----LIWTLAYKDYYHLGGGHHEP-----------------------------------------RRESRLTTRI----------------------------------VC--GN----V-PGLTP------K-QVALC------NEDPHAV-A-SAIQGLHVGVHECKRQFKNHRWNCSSLE-----------------------------T----KNKMPFNS--A--FLK-KA-------------------------SG-FKESSFAYAITAAGVAHQVAHACSL-GKINE-C-H-C-----------PL--------------------------------------------------------------------AGDNVNR--------F-------KYFGC-SH-NINFAINYSIKFLD--P-------------------------------------------------E-STK---DHTSMVRQHNNRVG-RL----IVG--QNMKRSCRCHGISGS-----CNQETCWYQTPNFREVGEMIKRKYESAQYHGELPSNN------------NVRP-NNAVST--------------------------------------------------------------------------------------ASND-A-LLY-YTTSP-RFCNPNHRL-AVAG----TKGRTCSR-T-----------------------------AP-PSDPSSCHHMC--CSRGYDTHREVRHE-KCHC-RFH------WCC--YVECQN-CTVSERVSVCR---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bfl_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-WRTILFW---------------------------VLLSLVP--------------------------------ELRATGNDIL----GLKIP------------------------------------------EDPVLNANT----------------------------------VC--RT----F-PGLSK------K-QLQLC------YEYPDVT-A-AAIQGVQIAIHECQWQFKNHRWNCSNLE-----------------------------T----KNKNPHLT--Q--IAS-K---------------------------G-IRETAFTFASVSAGVAHAVANACSL-GKLHT-C-G-C-DNDYPTKPQIPTYSPS-----SFPGAIPGGPIPGYP-PGYTQGQTAVLH---------------------------TNSGGGKSYND--------W-------SWGGC-SH-NIEYGIKFSKDFLD-SR-------------------------------------------------E-TSV---DIFSRMRLHNNRAG-RL----AVS--TNMQRRCKCHGMSGS-----CNLKTCWKATPDFREVGVILKERFDYATQIK-V-SN-------------DNYG-RLETIY----------------------------------------------------------------------------------ANRPPFAT-D-LVY-FDRSP-DFCDRNREL-ETPG----TRGRICNK-T------------------------------S-T-GPDSCAALC--CGRGFNIFRQTRVE-RCNC-KFH------WCC--YVICEE-CRITEWVNSCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bla_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-WRTILFW---------------------------VLLSLVP--------------------------------ELRATGNDIL----GLKIP------------------------------------------EDPVLNANT----------------------------------VC--RT----F-PGLSK------K-QLQLC------YEYPDVT-A-AAIQGVQIAIHECQWQFKNHRWNCSNLE-----------------------------T----KNKNPHLT--Q--IAS-K---------------------------G-IRETAFTFASVSAGVAHAVANACSL-GKLHT-C-G-C-DNDYPTKPQIPTYSPS-----SFPGAIPGGPIPGYP-PGYTQGQTAVLH---------------------------TNSGGGKSYND--------W-------SWGGC-SH-NIEYGIKFSKDFLD-SR-------------------------------------------------E-TSV---DIFSRMRLHNNRAG-RL----AVS--TNMQRRCKCHGMSGS-----CNLKTCWKATPDFREVGVILKERFDYATQIK-V-SN-------------DNYG-RLETIY----------------------------------------------------------------------------------ANRPPFAT-D-LVY-FDRSP-DFCDRNREL-ETPG----TRGRICNK-T------------------------------S-T-GPDSCAALC--CGRGFNIFRQTRVE-RCNC-KFH------WCC--YVICEE-CRITEWVNSCK---------------------------------------------------------------------------------------------------------------------------------------------------------------- Bbe_Wnt10 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-SSRELF---------------------------------PPC---------SSETAC--VGQYMCS------VQLRATGNDIL----GLKIP------------------------------------------EDPVLNANT----------------------------------VC--RT----F-PGLSK------K-QLQLC------YEYPDVT-A-AAIQGVQIAIHECQWQFKNHRWNCSNLE-----------------------------T----KNKNPHLT--Q--IAR-K---------------------------G-IRETAFTFASVSAGVAHAVANACSL-GKLHT-C-G-C-DNDYPTKPQIPTYSPS-----SFPGAIPGGPIPGYP-PGYTQGQTAVLH---------------------------TNSGGGKSYND--------W-------SWGGC-SH-NIEYGIKFSKDFLD-SR-------------------------------------------------E-TSV---DIFSRMRLHNNRAG-RL----AVS--TNMQRRCKCHGMSGS-----CNLKTCWKATPDFREVGVILKERFDYATQIK-V-SN-------------DNYG-RLETIY----------------------------------------------------------------------------------ANRPPFAT-D-LVY-FDRSP-DFCDRNREL-ETPG----TRGRICNK-T------------------------------S-S-GPDSCAALC--CGRGFNIFRQTRVE-RCNC-KFH------WCC--YVICEE-CRITEWVNSCK----------------------------------------------------------------------------------------------------------------------------------------------------------------